ITMI20030287A1 - Indazolammidi dotate di attivita' analgesica metodo, per - Google Patents

Indazolammidi dotate di attivita' analgesica metodo, per

Info

Publication number
ITMI20030287A1
ITMI20030287A1 IT000287A ITMI20030287A ITMI20030287A1 IT MI20030287 A1 ITMI20030287 A1 IT MI20030287A1 IT 000287 A IT000287 A IT 000287A IT MI20030287 A ITMI20030287 A IT MI20030287A IT MI20030287 A1 ITMI20030287 A1 IT MI20030287A1
Authority
IT
Italy
Prior art keywords
indazolamids
analgesic activity
activity method
analgesic
indazolamids equipped
Prior art date
Application number
IT000287A
Other languages
English (en)
Italian (it)
Inventor
Maria Alessandra Alisi
Isabella Coletta
Angelo Guglielmotti
Giuseppe Luna
Maurizio Magnani
Lorenzo Polenzani
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Priority to IT000287A priority Critical patent/ITMI20030287A1/it
Priority to AT04705070T priority patent/ATE471934T1/de
Priority to JP2006501608A priority patent/JP4724651B2/ja
Priority to CN2007101801011A priority patent/CN101139341B/zh
Priority to MXPA05008730A priority patent/MXPA05008730A/es
Priority to ES04705070T priority patent/ES2345983T3/es
Priority to DE602004027792T priority patent/DE602004027792D1/de
Priority to SI200431488T priority patent/SI1594859T1/sl
Priority to DK04705070.3T priority patent/DK1594859T3/da
Priority to KR1020057014055A priority patent/KR101108222B1/ko
Priority to EP04705070A priority patent/EP1594859B1/en
Priority to AU2004213104A priority patent/AU2004213104B2/en
Priority to EA200501164A priority patent/EA009077B1/ru
Priority to UAA200508163A priority patent/UA79537C2/uk
Priority to GEAP20048983A priority patent/GEP20074075B/en
Priority to CA2511984A priority patent/CA2511984C/en
Priority to HK05111137.6A priority patent/HK1079199B/en
Priority to PL377236A priority patent/PL215870B1/pl
Priority to PCT/EP2004/000647 priority patent/WO2004074275A1/en
Priority to PT04705070T priority patent/PT1594859E/pt
Priority to CNB2004800025681A priority patent/CN100347168C/zh
Priority to US10/541,209 priority patent/US7632849B2/en
Priority to ARP040100467A priority patent/AR043186A1/es
Publication of ITMI20030287A1 publication Critical patent/ITMI20030287A1/it
Priority to IL169285A priority patent/IL169285A/en
Priority to US12/607,463 priority patent/US8519139B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT000287A 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per ITMI20030287A1 (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per
AU2004213104A AU2004213104B2 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity
UAA200508163A UA79537C2 (en) 2003-02-18 2004-01-26 Indazolamides possessing analgesic activity
CN2007101801011A CN101139341B (zh) 2003-02-18 2004-01-26 具有止痛活性的吲唑酰胺类
MXPA05008730A MXPA05008730A (es) 2003-02-18 2004-01-26 Indazolamidas con actividad analgesica.
ES04705070T ES2345983T3 (es) 2003-02-18 2004-01-26 Indazolamidas con actividad analgesica.
DE602004027792T DE602004027792D1 (de) 2003-02-18 2004-01-26 Indazolamide mit analgetischer wirkung
SI200431488T SI1594859T1 (sl) 2003-02-18 2004-01-26 Indazolamidi z analgetsko aktivnostjo
DK04705070.3T DK1594859T3 (da) 2003-02-18 2004-01-26 Indazolamider med analgetisk aktivitet
KR1020057014055A KR101108222B1 (ko) 2003-02-18 2004-01-26 진통 작용을 가진 인다졸아마이드
EP04705070A EP1594859B1 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity
AT04705070T ATE471934T1 (de) 2003-02-18 2004-01-26 Indazolamide mit analgetischer wirkung
EA200501164A EA009077B1 (ru) 2003-02-18 2004-01-26 Индазоламиды с аналгетической активностью
CA2511984A CA2511984C (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity
GEAP20048983A GEP20074075B (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity
CNB2004800025681A CN100347168C (zh) 2003-02-18 2004-01-26 具有止痛活性的吲唑酰胺类
HK05111137.6A HK1079199B (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity
PL377236A PL215870B1 (pl) 2003-02-18 2004-01-26 Indazoloamidy, sposoby ich otrzymywania, kompozycje farmaceutyczne zawierajace te indazoloamidy oraz produkty posrednie powstajace przy wytwarzaniu tych indazoloamidów
PCT/EP2004/000647 WO2004074275A1 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity
PT04705070T PT1594859E (pt) 2003-02-18 2004-01-26 INDAZOLAMIDAS COM ACTIVIDADE ANALGéSICA
JP2006501608A JP4724651B2 (ja) 2003-02-18 2004-01-26 鎮痛作用を有するインダゾールアミド
US10/541,209 US7632849B2 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity
ARP040100467A AR043186A1 (es) 2003-02-18 2004-02-16 Indozolamidas dotadas de actividad analgesica, metodo de preparacion de las mismas y compuesto farmaceutico que las comprende
IL169285A IL169285A (en) 2003-02-18 2005-06-20 Indazolamides, process for their preparation, an intermediate thereof and pharmaceutical compositions comprising them
US12/607,463 US8519139B2 (en) 2003-02-18 2009-10-28 Indazolamides with analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per

Publications (1)

Publication Number Publication Date
ITMI20030287A1 true ITMI20030287A1 (it) 2004-08-19

Family

ID=32894157

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per

Country Status (22)

Country Link
US (2) US7632849B2 (enExample)
EP (1) EP1594859B1 (enExample)
JP (1) JP4724651B2 (enExample)
KR (1) KR101108222B1 (enExample)
CN (2) CN101139341B (enExample)
AR (1) AR043186A1 (enExample)
AT (1) ATE471934T1 (enExample)
AU (1) AU2004213104B2 (enExample)
CA (1) CA2511984C (enExample)
DE (1) DE602004027792D1 (enExample)
DK (1) DK1594859T3 (enExample)
EA (1) EA009077B1 (enExample)
ES (1) ES2345983T3 (enExample)
GE (1) GEP20074075B (enExample)
IL (1) IL169285A (enExample)
IT (1) ITMI20030287A1 (enExample)
MX (1) MXPA05008730A (enExample)
PL (1) PL215870B1 (enExample)
PT (1) PT1594859E (enExample)
SI (1) SI1594859T1 (enExample)
UA (1) UA79537C2 (enExample)
WO (1) WO2004074275A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
MXPA06014486A (es) * 2004-06-15 2007-03-01 Pfizer Derivados de acido carboxilico de bencimidazolona.
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
NZ587799A (en) * 2008-03-25 2012-06-29 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
BRPI1014902A2 (pt) * 2009-04-14 2016-04-19 Affectis Pharmaceuticals Ag composto antagonista de p2x7r, sua composição e seus usos
AU2013224313B2 (en) * 2012-02-21 2017-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
SG10201701649YA (en) 2012-02-21 2017-04-27 Acraf 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
HRP20220664T1 (hr) 2018-05-07 2022-06-24 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1h-indazol-3-karboksamid spojevi kao inhibitori glikogen sintaza kinaze 3 beta
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
IL117438A (en) 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
WO1996038420A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amino group
CA2209831C (en) * 1995-11-08 2005-05-10 Toray Industries, Inc. Directly imageable raw plate for waterless planographic printing plate
AU717177B2 (en) 1996-08-16 2000-03-16 Smithkline Beecham Plc Process for the preparation of N-((1-Nbutyl-4- piperidyl)methyl) -3,4-dihydro -2H-(1,3) oxazino(3,2-a) indole-10-carboxamide and salts and intermediates in the process
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
DE69940951D1 (de) * 1998-04-21 2009-07-16 Bristol Myers Squibb Pharma Co Nd wachstumshemmende mittel

Also Published As

Publication number Publication date
AR043186A1 (es) 2005-07-20
ES2345983T3 (es) 2010-10-07
KR101108222B1 (ko) 2012-02-08
MXPA05008730A (es) 2005-09-20
PL377236A1 (pl) 2006-01-23
PL215870B1 (pl) 2014-02-28
EA200501164A1 (ru) 2005-12-29
US20060052417A1 (en) 2006-03-09
AU2004213104B2 (en) 2010-07-08
AU2004213104A1 (en) 2004-09-02
CN100347168C (zh) 2007-11-07
IL169285A (en) 2012-08-30
EA009077B1 (ru) 2007-10-26
WO2004074275A1 (en) 2004-09-02
CN1742004A (zh) 2006-03-01
CN101139341B (zh) 2010-12-08
US7632849B2 (en) 2009-12-15
CA2511984C (en) 2011-01-18
JP2006517932A (ja) 2006-08-03
JP4724651B2 (ja) 2011-07-13
SI1594859T1 (sl) 2010-10-29
KR20050101541A (ko) 2005-10-24
CA2511984A1 (en) 2004-09-02
EP1594859A1 (en) 2005-11-16
CN101139341A (zh) 2008-03-12
ATE471934T1 (de) 2010-07-15
DE602004027792D1 (de) 2010-08-05
UA79537C2 (en) 2007-06-25
HK1079199A1 (en) 2006-03-31
DK1594859T3 (da) 2010-10-11
US8519139B2 (en) 2013-08-27
EP1594859B1 (en) 2010-06-23
US20100048907A1 (en) 2010-02-25
PT1594859E (pt) 2010-07-23
GEP20074075B (en) 2007-03-26

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