CN101139341B - 具有止痛活性的吲唑酰胺类 - Google Patents

具有止痛活性的吲唑酰胺类 Download PDF

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Publication number
CN101139341B
CN101139341B CN2007101801011A CN200710180101A CN101139341B CN 101139341 B CN101139341 B CN 101139341B CN 2007101801011 A CN2007101801011 A CN 2007101801011A CN 200710180101 A CN200710180101 A CN 200710180101A CN 101139341 B CN101139341 B CN 101139341B
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CN
China
Prior art keywords
indazole
mol
methyl
piperidinyl
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007101801011A
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English (en)
Chinese (zh)
Other versions
CN101139341A (zh
Inventor
M·A·阿里希
N·卡佐尔拉
A·古格利尔莫蒂
G·弗尔罗蒂
G·鲁纳
L·普兰扎尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco ACRAF SpA filed Critical Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Publication of CN101139341A publication Critical patent/CN101139341A/zh
Application granted granted Critical
Publication of CN101139341B publication Critical patent/CN101139341B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2007101801011A 2003-02-18 2004-01-26 具有止痛活性的吲唑酰胺类 Expired - Fee Related CN101139341B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per
ITMI2003A000287 2003-02-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800025681A Division CN100347168C (zh) 2003-02-18 2004-01-26 具有止痛活性的吲唑酰胺类

Publications (2)

Publication Number Publication Date
CN101139341A CN101139341A (zh) 2008-03-12
CN101139341B true CN101139341B (zh) 2010-12-08

Family

ID=32894157

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2007101801011A Expired - Fee Related CN101139341B (zh) 2003-02-18 2004-01-26 具有止痛活性的吲唑酰胺类
CNB2004800025681A Expired - Fee Related CN100347168C (zh) 2003-02-18 2004-01-26 具有止痛活性的吲唑酰胺类

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB2004800025681A Expired - Fee Related CN100347168C (zh) 2003-02-18 2004-01-26 具有止痛活性的吲唑酰胺类

Country Status (22)

Country Link
US (2) US7632849B2 (enExample)
EP (1) EP1594859B1 (enExample)
JP (1) JP4724651B2 (enExample)
KR (1) KR101108222B1 (enExample)
CN (2) CN101139341B (enExample)
AR (1) AR043186A1 (enExample)
AT (1) ATE471934T1 (enExample)
AU (1) AU2004213104B2 (enExample)
CA (1) CA2511984C (enExample)
DE (1) DE602004027792D1 (enExample)
DK (1) DK1594859T3 (enExample)
EA (1) EA009077B1 (enExample)
ES (1) ES2345983T3 (enExample)
GE (1) GEP20074075B (enExample)
IL (1) IL169285A (enExample)
IT (1) ITMI20030287A1 (enExample)
MX (1) MXPA05008730A (enExample)
PL (1) PL215870B1 (enExample)
PT (1) PT1594859E (enExample)
SI (1) SI1594859T1 (enExample)
UA (1) UA79537C2 (enExample)
WO (1) WO2004074275A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
AU2005254800B2 (en) 2004-06-15 2010-12-09 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
EP2105164B1 (en) * 2008-03-25 2011-01-12 Affectis Pharmaceuticals AG Novel P2X7R antagonists and their use
ATE541832T1 (de) * 2009-04-14 2012-02-15 Affectis Pharmaceuticals Ag Neuartige p2x7r-antagonisten und ihre verwendung
MX351287B (es) * 2012-02-21 2017-10-09 Acraf Compuestos de 1h-indazol-3-carboxamida como inhibidores de glucogeno sintasa quinasa 3 beta.
CA2860466C (en) 2012-02-21 2020-02-18 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.S.P.A. Use of 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
IL278330B2 (en) 2018-05-07 2024-06-01 Acraf 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) * 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
CA2222532A1 (en) 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
CN1093801C (zh) * 1995-11-08 2002-11-06 东丽株式会社 直接成像型无水平版印刷版原版
ATE197588T1 (de) 1996-08-16 2000-12-15 Smithkline Beecham Plc Verfahren zur herstellung von n- (1-n-butyl-4- piperidinyl)methyl) -3,4-dihydro -2h-(1, 3)oxazino(3,2-a)indol-10-carboxamid und salze sowie zwischenprodukte in dem verfahren
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
NZ507567A (en) * 1998-04-21 2003-08-29 Du Pont Pharm Co 5-aminoindeno(1,2-c)pyrazol-4-ones as anti-cancer and anti-proliferative agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) * 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides

Also Published As

Publication number Publication date
KR101108222B1 (ko) 2012-02-08
KR20050101541A (ko) 2005-10-24
JP4724651B2 (ja) 2011-07-13
JP2006517932A (ja) 2006-08-03
PL215870B1 (pl) 2014-02-28
AR043186A1 (es) 2005-07-20
CA2511984C (en) 2011-01-18
CN1742004A (zh) 2006-03-01
CN100347168C (zh) 2007-11-07
ATE471934T1 (de) 2010-07-15
US20060052417A1 (en) 2006-03-09
DK1594859T3 (da) 2010-10-11
IL169285A (en) 2012-08-30
PT1594859E (pt) 2010-07-23
ITMI20030287A1 (it) 2004-08-19
MXPA05008730A (es) 2005-09-20
SI1594859T1 (sl) 2010-10-29
ES2345983T3 (es) 2010-10-07
WO2004074275A1 (en) 2004-09-02
CN101139341A (zh) 2008-03-12
CA2511984A1 (en) 2004-09-02
US7632849B2 (en) 2009-12-15
EP1594859B1 (en) 2010-06-23
AU2004213104A1 (en) 2004-09-02
US8519139B2 (en) 2013-08-27
EA009077B1 (ru) 2007-10-26
PL377236A1 (pl) 2006-01-23
HK1079199A1 (en) 2006-03-31
AU2004213104B2 (en) 2010-07-08
EP1594859A1 (en) 2005-11-16
US20100048907A1 (en) 2010-02-25
EA200501164A1 (ru) 2005-12-29
DE602004027792D1 (de) 2010-08-05
UA79537C2 (en) 2007-06-25
GEP20074075B (en) 2007-03-26

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20101208

Termination date: 20180126