ITMI20010733A0 - Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria - Google Patents

Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria

Info

Publication number
ITMI20010733A0
ITMI20010733A0 IT2001MI000733A ITMI20010733A ITMI20010733A0 IT MI20010733 A0 ITMI20010733 A0 IT MI20010733A0 IT 2001MI000733 A IT2001MI000733 A IT 2001MI000733A IT MI20010733 A ITMI20010733 A IT MI20010733A IT MI20010733 A0 ITMI20010733 A0 IT MI20010733A0
Authority
IT
Italy
Prior art keywords
isoenzine
cox
inhibitors
treatment
urinary incontinence
Prior art date
Application number
IT2001MI000733A
Other languages
English (en)
Inventor
Amedeo Leonardi
Rodolfo Testa
Luciano Guarneri
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Priority to IT2001MI000733A priority Critical patent/ITMI20010733A1/it
Publication of ITMI20010733A0 publication Critical patent/ITMI20010733A0/it
Priority to US09/969,538 priority patent/US6440963B1/en
Priority to CNA028078101A priority patent/CN1688315A/zh
Priority to CA002443031A priority patent/CA2443031A1/en
Priority to AU2002253181A priority patent/AU2002253181B2/en
Priority to KR10-2003-7012891A priority patent/KR20030087046A/ko
Priority to PCT/EP2002/003850 priority patent/WO2002080927A1/en
Priority to JP2002578966A priority patent/JP2004531514A/ja
Priority to MXPA03008966A priority patent/MXPA03008966A/es
Priority to EP02722290A priority patent/EP1381369A1/en
Priority to RU2003132445/15A priority patent/RU2003132445A/ru
Priority to HU0303908A priority patent/HUP0303908A2/hu
Priority to IL15805002A priority patent/IL158050A0/xx
Priority to BR0208694-8A priority patent/BR0208694A/pt
Priority to PL02364465A priority patent/PL364465A1/xx
Publication of ITMI20010733A1 publication Critical patent/ITMI20010733A1/it
Priority to ZA200307731A priority patent/ZA200307731B/xx
Priority to NO20034473A priority patent/NO20034473L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT2001MI000733A 2001-04-05 2001-04-05 Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria ITMI20010733A1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT2001MI000733A ITMI20010733A1 (it) 2001-04-05 2001-04-05 Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria
US09/969,538 US6440963B1 (en) 2001-04-05 2001-10-01 Use of selective COX-2 inhibitors for the treatment of urinary incontinence
PL02364465A PL364465A1 (en) 2001-04-05 2002-04-05 Use of selective cox-2 inhibitors for the treatment of urinary incontinence
MXPA03008966A MXPA03008966A (es) 2001-04-05 2002-04-05 Uso de inhibidores selectivos de ciclooxigenasa-2 para el tratamiento de incontinencia urinaria.
EP02722290A EP1381369A1 (en) 2001-04-05 2002-04-05 Use of selective cox-2 inhibitors for the treatment of urinary incontinence
AU2002253181A AU2002253181B2 (en) 2001-04-05 2002-04-05 Use of selective COX-2 inhibitors for the treatment of urinary incontinence
KR10-2003-7012891A KR20030087046A (ko) 2001-04-05 2002-04-05 요실금 치료에서 선택적 ｃｏｘ-2 억제물질의 용도
PCT/EP2002/003850 WO2002080927A1 (en) 2001-04-05 2002-04-05 Use of selective cox-2 inhibitors for the treatment of urinary incontinence
JP2002578966A JP2004531514A (ja) 2001-04-05 2002-04-05 尿失禁の処置のための選択的ｃｏｘ−２阻害剤の使用
CNA028078101A CN1688315A (zh) 2001-04-05 2002-04-05 用选择性cox－2抑制剂治疗尿失禁
CA002443031A CA2443031A1 (en) 2001-04-05 2002-04-05 Use of selective cox-2 inhibitors for the treatment of urinary incontinence
RU2003132445/15A RU2003132445A (ru) 2001-04-05 2002-04-05 Применение селективных ингибиторов сох-2 для лечения недержания мочи
HU0303908A HUP0303908A2 (hu) 2001-04-05 2002-04-05 Szelektív COX-2 inhibitorok alkalmazása inkontinencia kezelésére szolgáló gyógyszerkészítmény előállítására
IL15805002A IL158050A0 (en) 2001-04-05 2002-04-05 Use of selective cox-2 inhibitors for the treatment of urinary incontinence
BR0208694-8A BR0208694A (pt) 2001-04-05 2002-04-05 Uso de inibidores de cox-2 seletivos para tratamento de incontinência urinária
ZA200307731A ZA200307731B (en) 2001-04-05 2003-10-03 Use of selective COX-2inhibitors for the treatment of urinary incontinence.
NO20034473A NO20034473L (no) 2001-04-05 2003-10-06 Anvendelse av selektive cox-2-inhibitorer ved behandling av urininkontinens

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001MI000733A ITMI20010733A1 (it) 2001-04-05 2001-04-05 Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria

Publications (2)

Publication Number Publication Date
ITMI20010733A0 true ITMI20010733A0 (it) 2001-04-05
ITMI20010733A1 ITMI20010733A1 (it) 2002-10-05

Family

ID=11447449

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2001MI000733A ITMI20010733A1 (it) 2001-04-05 2001-04-05 Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria

Country Status (17)

Country Link
US (1) US6440963B1 (it)
EP (1) EP1381369A1 (it)
JP (1) JP2004531514A (it)
KR (1) KR20030087046A (it)
CN (1) CN1688315A (it)
AU (1) AU2002253181B2 (it)
BR (1) BR0208694A (it)
CA (1) CA2443031A1 (it)
HU (1) HUP0303908A2 (it)
IL (1) IL158050A0 (it)
IT (1) ITMI20010733A1 (it)
MX (1) MXPA03008966A (it)
NO (1) NO20034473L (it)
PL (1) PL364465A1 (it)
RU (1) RU2003132445A (it)
WO (1) WO2002080927A1 (it)
ZA (1) ZA200307731B (it)

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PL372395A1 (en) * 2002-02-19 2005-07-25 Pharmacia Corporation Use of cyclooxygenase inhibitors and antimuscarinic agents for the treatment of incontinence
EP1915992A1 (en) * 2002-02-19 2008-04-30 Pharmacia Corporation Use of cyclooxygenase inhibitors and antimuscarinic agents for the treatment of incontinence
CN1659131A (zh) * 2002-04-08 2005-08-24 葛兰素集团有限公司 2－((2－烷氧基)－苯基)－环戊－1－烯基)芳香碳－以及杂环羧酸及其衍生物
EP1400243A1 (en) * 2002-09-19 2004-03-24 Tanabe Seiyaku Co., Ltd. Calcium-activated K channel activator
GB0225548D0 (en) * 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
ATE490244T1 (de) * 2003-01-27 2010-12-15 Merck Sharp & Dohme Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren
US20050075359A1 (en) * 2003-03-14 2005-04-07 Rikako Kono Large conductance calcium-activated K channel opener
GB0323581D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Novel compounds
GB0323585D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
GB0323584D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
WO2005037271A2 (en) * 2003-10-17 2005-04-28 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
GB0410121D0 (en) * 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds
MY143599A (en) * 2004-06-04 2011-06-15 Merck Sharp & Dohme Pyrazole derivatives, compositions containing such compounds and methods of use
US20070281927A1 (en) * 2006-06-06 2007-12-06 Shanthakumar Tyavanagimatt Anti-inflammatory and analgesic compositions and related methods
MX2009006575A (es) * 2006-12-22 2009-07-02 Recordati Ireland Ltd Terapia de combinacion de trastornos del tracto urinario inferior con ligandos a2d y farmacos anti-inflamatorios no esteroidales (nsaids).
EP2280948A1 (en) 2008-04-09 2011-02-09 Mitsubishi Tanabe Pharma Corporation Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers.
CN105555363B (zh) 2013-05-06 2019-03-12 长庚医疗财团法人高雄长庚纪念医院 医药组成物及其用途
CN108690078A (zh) * 2017-03-29 2018-10-23 江苏恒瑞医药股份有限公司 一种苯并塞嗪磷酸酯衍生物、其制备方法及其在医药上的应用

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Also Published As

Publication number Publication date
EP1381369A1 (en) 2004-01-21
BR0208694A (pt) 2004-03-30
WO2002080927A1 (en) 2002-10-17
PL364465A1 (en) 2004-12-13
NO20034473D0 (no) 2003-10-06
ZA200307731B (en) 2004-09-13
KR20030087046A (ko) 2003-11-12
MXPA03008966A (es) 2004-10-15
ITMI20010733A1 (it) 2002-10-05
RU2003132445A (ru) 2005-03-10
NO20034473L (no) 2003-12-05
AU2002253181B2 (en) 2005-02-17
JP2004531514A (ja) 2004-10-14
US6440963B1 (en) 2002-08-27
CN1688315A (zh) 2005-10-26
HUP0303908A2 (hu) 2004-04-28
CA2443031A1 (en) 2002-10-17
IL158050A0 (en) 2004-03-28

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