IT8419435A0 - Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandi olo e loro intermedi. - Google Patents

Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandi olo e loro intermedi.

Info

Publication number
IT8419435A0
IT8419435A0 IT8419435A IT1943584A IT8419435A0 IT 8419435 A0 IT8419435 A0 IT 8419435A0 IT 8419435 A IT8419435 A IT 8419435A IT 1943584 A IT1943584 A IT 1943584A IT 8419435 A0 IT8419435 A0 IT 8419435A0
Authority
IT
Italy
Prior art keywords
fluorinating
intermediates
propane
phenyl
derivatives
Prior art date
Application number
IT8419435A
Other languages
English (en)
Other versions
IT1173213B (it
Inventor
Giancarlo Jommi
Dario Chiarino
Roberto Pagliarin
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IT8419435A0 publication Critical patent/IT8419435A0/it
Priority to IT19435/84A priority Critical patent/IT1173213B/it
Priority to DE3486438T priority patent/DE3486438T2/de
Priority to EP84200772A priority patent/EP0130633B1/en
Priority to EP95201522A priority patent/EP0677511A3/en
Priority to AT84200772T priority patent/ATE143953T1/de
Priority to EP95201523A priority patent/EP0678506A3/en
Priority to ES533355A priority patent/ES533355A0/es
Priority to JP59113774A priority patent/JPH0819085B2/ja
Priority to US06/697,568 priority patent/US4743700A/en
Application granted granted Critical
Publication of IT1173213B publication Critical patent/IT1173213B/it
Priority to US07/870,777 priority patent/US5153328A/en
Priority to US08/065,521 priority patent/US5332835A/en
Priority to US08/240,432 priority patent/US5567844A/en
Priority to JP7287772A priority patent/JP2721959B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IT19435/84A 1983-06-02 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi IT1173213B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT19435/84A IT1173213B (it) 1984-02-03 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi
DE3486438T DE3486438T2 (de) 1983-06-02 1984-05-29 Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten
EP84200772A EP0130633B1 (en) 1983-06-02 1984-05-29 Process for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
EP95201522A EP0677511A3 (en) 1983-06-02 1984-05-29 Intermediates for the production of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
AT84200772T ATE143953T1 (de) 1983-06-02 1984-05-29 Verfahren zur herstellung von 1-(phenyl)-1- hydroxy-2-amino-3-fluor-propan-derivaten
EP95201523A EP0678506A3 (en) 1983-06-02 1984-05-29 Intermediates for the preparation of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
ES533355A ES533355A0 (es) 1983-06-02 1984-06-01 Procedimiento para la preparacion de derivados de 1-(fenil)-1-hidroxi-2-amino-3-fluoro-propano
JP59113774A JPH0819085B2 (ja) 1983-06-02 1984-06-02 １−（フエニル）−１−ヒドロキシ−２−アミノ−３−フルオロプロパン誘導体製造用中間体
US06/697,568 US4743700A (en) 1984-02-03 1985-02-01 Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds
US07/870,777 US5153328A (en) 1984-02-03 1992-04-21 2 Hydrocarbyl-4 substituted methyl 5 (4 substituted phenyl)-oxazolines
US08/065,521 US5332835A (en) 1984-02-03 1993-05-24 Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US08/240,432 US5567844A (en) 1984-02-03 1994-05-10 Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols
JP7287772A JP2721959B2 (ja) 1983-06-02 1995-09-29 １−（フェニル）−１−ヒドロキシー２−アミノー３−フルオロプロパン誘導体製造用中間体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19435/84A IT1173213B (it) 1984-02-03 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi

Publications (2)

Publication Number Publication Date
IT8419435A0 true IT8419435A0 (it) 1984-02-03
IT1173213B IT1173213B (it) 1987-06-18

Family

ID=11157919

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19435/84A IT1173213B (it) 1983-06-02 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi

Country Status (2)

Country Link
US (1) US4743700A (it)
IT (1) IT1173213B (it)

Families Citing this family (41)

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US5243056A (en) * 1983-06-02 1993-09-07 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
US5153328A (en) * 1984-02-03 1992-10-06 Zambon S.P.A. 2 Hydrocarbyl-4 substituted methyl 5 (4 substituted phenyl)-oxazolines
US5332835A (en) * 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US5227494A (en) * 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
IT1240676B (it) * 1990-04-24 1993-12-17 Agrimont Spa Composizioni ad attivita' erbicida
DK0555340T3 (da) * 1990-10-25 1995-03-06 Schering Corp Fremgangsmåde til fremstilling af florfenicol, analoger heraf og oxazolinmellemprodukter dertil
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
EP1318794A2 (en) * 2000-09-22 2003-06-18 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
WO2003077828A2 (en) * 2002-03-08 2003-09-25 Schering-Plough, Ltd. Novel florfenicol-type antibiotics
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
CA2576589C (en) * 2004-08-13 2013-11-12 Schering-Plough Ltd. Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
US7402697B2 (en) * 2004-09-02 2008-07-22 Idexx Laboratories Inc. Antibacterial agents
WO2006034333A2 (en) 2004-09-23 2006-03-30 Schering-Plough Ltd. Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
ATE446677T1 (de) * 2004-11-19 2009-11-15 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h- pyrrol-2-yl) acrylonitril-derivaten
AU2005318187B2 (en) * 2004-12-21 2010-12-16 Intervet International B.V. Injectable veterinary composition
CA2609574A1 (en) * 2005-06-09 2006-12-21 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
WO2008076256A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
CA2672586A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
JP2010525059A (ja) * 2007-04-27 2010-07-22 シェーリング−プラウ・リミテッド シクロデキストリンを用いてフロルフェニコールおよび構造的に関連する抗生物質の溶解度を高めるための化合物および方法
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
PT2957284T (pt) 2007-06-27 2018-04-23 Du Pont Método de controlo de pragas em animais
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
WO2009061780A1 (en) * 2007-11-09 2009-05-14 Schering-Plough Limited Fast release solid formulation, preparation and use thereof
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
CN102131772B (zh) * 2008-07-30 2015-03-11 英特威国际有限公司 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
AU2010279574A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
MX2012001646A (es) 2009-08-05 2012-03-21 Du Pont Pesticidas mesoionicos.
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
DK2576523T3 (en) 2010-05-27 2016-04-18 Du Pont A crystalline form of 4- [5- [3-chloro-5- (trifluoromethyl) phenyl] -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N- [2-oxo-2 - [( 2,2,2-trifluoroethyl) amino] ethyl] - 1-naphthalenecarboxamide
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013057619A1 (en) * 2011-10-17 2013-04-25 Ah Usa 42 Llc Novel phenicol antibacterials
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN103965085B (zh) * 2014-04-17 2016-02-24 上海恒晟药业有限公司 一种取代1,2-氨基醇药物的制备方法

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US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor

Also Published As

Publication number Publication date
IT1173213B (it) 1987-06-18
US4743700A (en) 1988-05-10

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