IT8348327A0 - Preparato farmaceutico ad azione specifica localizzata e prolungata sul cervello e procedimento di preparazione - Google Patents
Preparato farmaceutico ad azione specifica localizzata e prolungata sul cervello e procedimento di preparazioneInfo
- Publication number
- IT8348327A0 IT8348327A0 IT8348327A IT4832783A IT8348327A0 IT 8348327 A0 IT8348327 A0 IT 8348327A0 IT 8348327 A IT8348327 A IT 8348327A IT 4832783 A IT4832783 A IT 4832783A IT 8348327 A0 IT8348327 A0 IT 8348327A0
- Authority
- IT
- Italy
- Prior art keywords
- preparation
- brain
- prolonged action
- specific localized
- pharmaceutical preparation
- Prior art date
Links
- 210000004556 brain Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 230000002035 prolonged effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/559—Redox delivery systems, e.g. dihydropyridine pyridinium salt redox systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/379,316 US4479932A (en) | 1982-05-18 | 1982-05-18 | Brain-specific drug delivery |
| US46154383A | 1983-01-27 | 1983-01-27 | |
| US06/475,493 US4622218A (en) | 1982-05-18 | 1983-03-15 | Testicular-specific drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8348327A0 true IT8348327A0 (it) | 1983-05-18 |
| IT1171851B IT1171851B (it) | 1987-06-10 |
Family
ID=27409446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT48327/83A IT1171851B (it) | 1982-05-18 | 1983-05-18 | Preparato farmaceutico ad azione specifica localizzata e prolungata sul cervello e procedimento di preparazione |
Country Status (9)
| Country | Link |
|---|---|
| EP (6) | EP0256577A3 (it) |
| AT (1) | ATE126695T1 (it) |
| AU (1) | AU567433B2 (it) |
| CA (2) | CA1253856A (it) |
| DE (1) | DE3382795T2 (it) |
| ES (1) | ES8502087A1 (it) |
| IE (1) | IE69557B1 (it) |
| IT (1) | IT1171851B (it) |
| WO (1) | WO1983003968A1 (it) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5082853A (en) * | 1984-02-29 | 1992-01-21 | Bodor Nicholas S | Brain-specific analogues of centrally acting amines |
| US4933438A (en) * | 1984-02-29 | 1990-06-12 | University Of Florida | Brain-specific analogues of centrally acting amines |
| JPS61501562A (ja) * | 1984-02-29 | 1986-07-31 | ユニバ−シティ・オブ フロリダ | 中枢作用アミン類の脳特異性類似化合物 |
| US4771059A (en) * | 1984-02-29 | 1988-09-13 | University Of Florida | Brain-specific analogues of centrally acting amines |
| US4963688A (en) * | 1984-07-19 | 1990-10-16 | University Of Florida | Compounds for site-enhanced delivery of radionuclides and uses thereof |
| EP0191788A1 (en) * | 1984-07-19 | 1986-08-27 | University Of Florida | Novel radiopharmaceuticals and chelating agents useful in their preparation |
| WO1986000898A1 (en) * | 1984-07-19 | 1986-02-13 | University Of Florida | Compounds for site-enhanced delivery of radionuclides and uses thereof |
| US4764598A (en) * | 1985-08-22 | 1988-08-16 | The United States Of America As Represented By The Department Of Energy | Precursors to radiopharmaceutical agents for tissue imaging |
| US4863911A (en) * | 1986-08-04 | 1989-09-05 | University Of Florida | Method for treating male sexual dysfunction |
| US4888427A (en) * | 1987-04-07 | 1989-12-19 | University Of Florida | Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain |
| US5079366A (en) * | 1987-04-07 | 1992-01-07 | University Of Florida | Quarternary pyridinium salts |
| US5017566A (en) * | 1987-12-30 | 1991-05-21 | University Of Florida | Redox systems for brain-targeted drug delivery |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| DK0386644T3 (da) * | 1989-03-10 | 1997-10-13 | Hoffmann La Roche | Reagenser til bestemmelse af lægemidler |
| IL106998A0 (en) * | 1992-09-17 | 1993-12-28 | Univ Florida | Brain-enhanced delivery of neuroactive peptides by sequential metabolism |
| KR101301577B1 (ko) * | 2010-08-20 | 2013-08-29 | 주식회사 바이오에프디엔씨 | 니코티노일 펩타이드 유도체 및 그를 포함하는 화장료 조성물 |
| ES2655669T3 (es) | 2011-12-21 | 2018-02-21 | Ono Pharmaceutical Co., Ltd. | Derivados de piridinona y pirimidinona como inhibidores del factor XIa |
| US10752589B2 (en) * | 2016-03-14 | 2020-08-25 | Sphaera Pharma Pvt. Ltd. | Trigonelline based compounds |
| WO2018054721A1 (en) | 2016-09-26 | 2018-03-29 | Basf Se | Pyridine compounds for controlling phytopathogenic harmful fungi |
| WO2018054723A1 (en) | 2016-09-26 | 2018-03-29 | Basf Se | Pyridine compounds for controlling phytopathogenic harmful fungi |
| WO2018054711A1 (en) | 2016-09-26 | 2018-03-29 | Basf Se | Pyridine compounds for controlling phytopathogenic harmful fungi |
| WO2018065182A1 (en) | 2016-10-04 | 2018-04-12 | Basf Se | Reduced quinoline compounds as antifuni agents |
| WO2018073110A1 (en) | 2016-10-20 | 2018-04-26 | Basf Se | Quinoline compounds as fungicides |
| BR112019014061A2 (pt) | 2017-01-23 | 2020-02-04 | Basf Se | compostos de fórmula i, intermediários b, intermediários c, intermediários ii e intermediários d, composição, uso, método para combater fungos fitopatogênicos, semente e processo para a síntese dos compostos de fórmula i |
| EP3606914A1 (en) | 2017-04-06 | 2020-02-12 | Basf Se | Pyridine compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3962447A (en) | 1973-12-26 | 1976-06-08 | Interx Research Corporation | Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and method of using same |
| US3929813A (en) | 1973-12-26 | 1975-12-30 | Interx Research Corp | Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same |
| US4069322A (en) * | 1976-10-12 | 1978-01-17 | Interx Research Corporation | Pro-drugs for the improved delivery of certain selected anti-inflammatory steroids |
| US4206220A (en) * | 1978-07-13 | 1980-06-03 | Interx Research Corporation | Prodrugs for the improved delivery of non-steroidal anti-inflammatory agents |
-
1983
- 1983-05-12 EP EP87201385A patent/EP0256577A3/en not_active Withdrawn
- 1983-05-12 EP EP83902034A patent/EP0110955B1/en not_active Expired - Lifetime
- 1983-05-12 EP EP86201713A patent/EP0224283A3/en not_active Withdrawn
- 1983-05-12 EP EP86201714A patent/EP0222425A3/en not_active Withdrawn
- 1983-05-12 EP EP87201384A patent/EP0262696A3/en not_active Withdrawn
- 1983-05-12 AU AU17034/83A patent/AU567433B2/en not_active Expired
- 1983-05-12 EP EP86201711A patent/EP0221588A3/en not_active Withdrawn
- 1983-05-12 WO PCT/US1983/000725 patent/WO1983003968A1/en active IP Right Grant
- 1983-05-12 DE DE3382795T patent/DE3382795T2/de not_active Expired - Lifetime
- 1983-05-12 AT AT83902034T patent/ATE126695T1/de not_active IP Right Cessation
- 1983-05-16 CA CA000428192A patent/CA1253856A/en not_active Expired
- 1983-05-17 ES ES522489A patent/ES8502087A1/es not_active Expired
- 1983-05-17 IE IE114983A patent/IE69557B1/en not_active IP Right Cessation
- 1983-05-18 IT IT48327/83A patent/IT1171851B/it active
-
1989
- 1989-02-09 CA CA000590673A patent/CA1327566C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0221588A3 (en) | 1988-09-21 |
| IE69557B1 (en) | 1996-10-02 |
| EP0222425A3 (en) | 1988-09-21 |
| IT1171851B (it) | 1987-06-10 |
| EP0110955B1 (en) | 1995-08-23 |
| EP0222425A2 (en) | 1987-05-20 |
| IE931149L (en) | 1983-11-18 |
| EP0224283A3 (en) | 1988-09-21 |
| ATE126695T1 (de) | 1995-09-15 |
| EP0256577A2 (en) | 1988-02-24 |
| EP0224283A2 (en) | 1987-06-03 |
| CA1253856A (en) | 1989-05-09 |
| AU567433B2 (en) | 1987-11-19 |
| DE3382795D1 (de) | 1995-09-28 |
| WO1983003968A1 (en) | 1983-11-24 |
| ES522489A0 (es) | 1984-12-16 |
| EP0256577A3 (en) | 1988-07-06 |
| ES8502087A1 (es) | 1984-12-16 |
| EP0110955A1 (en) | 1984-06-20 |
| IE831149L (en) | 1983-11-18 |
| EP0262696A2 (en) | 1988-04-06 |
| CA1327566C (en) | 1994-03-08 |
| AU1703483A (en) | 1983-12-02 |
| DE3382795T2 (de) | 1996-02-15 |
| EP0262696A3 (en) | 1988-07-20 |
| EP0221588A2 (en) | 1987-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970530 |