IT201900009564A1 - "ANTI-AGING DERMOCOSMETIC CREAM" - Google Patents
"ANTI-AGING DERMOCOSMETIC CREAM" Download PDFInfo
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- IT201900009564A1 IT201900009564A1 IT102019000009564A IT201900009564A IT201900009564A1 IT 201900009564 A1 IT201900009564 A1 IT 201900009564A1 IT 102019000009564 A IT102019000009564 A IT 102019000009564A IT 201900009564 A IT201900009564 A IT 201900009564A IT 201900009564 A1 IT201900009564 A1 IT 201900009564A1
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- Prior art keywords
- cream
- dermocosmetic
- vitamin
- skin
- phosphatidylcholine
- Prior art date
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- 239000006071 cream Substances 0.000 title claims description 19
- 230000003712 anti-aging effect Effects 0.000 title description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 15
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 15
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 15
- 235000019155 vitamin A Nutrition 0.000 claims description 15
- 239000011719 vitamin A Substances 0.000 claims description 15
- 229940045997 vitamin a Drugs 0.000 claims description 15
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 12
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 claims description 10
- 229960001284 citicoline Drugs 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 239000002502 liposome Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 description 16
- 230000000694 effects Effects 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 5
- 230000032677 cell aging Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000004075 alteration Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 230000037303 wrinkles Effects 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 2
- 230000036620 skin dryness Effects 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003930 cognitive ability Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- UHDGCWIWMRVCDJ-XVFCMESISA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-XVFCMESISA-N 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000006355 external stress Effects 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001777 nootropic effect Effects 0.000 description 1
- 238000009329 organic farming Methods 0.000 description 1
- -1 phosphatidylcholine lipid Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002582 psychostimulating effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
Descrizione del Brevetto per Invenzione Industriale dal titolo: Description of the Patent for Industrial Invention entitled:
“Crema dermocosmetica anti-invecchiamento” "Anti-aging dermocosmetic cream"
Il trovato oggetto della presente invenzione si colloca nel settore della medicina estetica, e concerne una composizione dermocosmetica per il trattamento degli inestetismi della senescenza cutanea. The object of the present invention is placed in the field of aesthetic medicine, and concerns a dermocosmetic composition for the treatment of skin senescence imperfections.
Più in particolare, il trovato si riferisce ad una composizione avente un effetto tensore sulla pelle del viso e del collo, già dopo solo una settimana dalla sua costante applicazione. More particularly, the invention refers to a composition having a tightening effect on the skin of the face and neck, already after only one week from its constant application.
La cute è soggetta ad un naturale processo di rinnovamento costituito dalla continua sostituzione di cellule morte con quelle nuove. Detto ciclo naturale di rigenerazione rallenta con l’avanzare dell’età causando alterazioni alle condizioni cutanee. La pelle produce meno proteine, il derma diventa più sottile e la perdita di elasticità provoca la comparsa di piccole rughe e l’attenuarsi della luminosità del viso. The skin is subject to a natural renewal process consisting of the continuous replacement of dead cells with new ones. This natural regeneration cycle slows down with advancing age causing alterations to skin conditions. The skin produces less protein, the dermis becomes thinner and the loss of elasticity causes the appearance of small wrinkles and the brightness of the face diminishes.
Per contrastare l’invecchiamento della pelle, la tecnica nota ha messo a disposizione una grande varietà di preparazioni per la cura ed il trattamento del corpo per applicazione topica, tuttavia, la maggior parte di queste formulazioni per creme anti-invecchiamento contengono particolari componenti in grado di svolgere una specifica azione solo su una specifica zona, ad esempio contorno occhi e contorno bocca. To counteract skin aging, the known technique has made available a great variety of preparations for the care and treatment of the body for topical application, however, most of these formulations for anti-aging creams contain particular components capable of to perform a specific action only on a specific area, for example eye contour and mouth contour.
Inoltre, molte delle composizioni note, presentano degli inconvenienti derivanti dalle loro caratteristiche intrinseche, appiccicosità, secchezza cutanea, arrossamenti cutanei ed effetto tensore non significativo. Furthermore, many of the known compositions have drawbacks deriving from their intrinsic characteristics, stickiness, skin dryness, skin redness and an insignificant tightening effect.
Le formulazioni note poi, non si dimostrano particolarmente efficaci ed i loro effetti sono di breve durata. Furthermore, the known formulations do not prove particularly effective and their effects are short-lived.
Scopo principale della presente invenzione è quello di fornire una crema dermocosmetica ad effetto tensore, in grado di superare gli inconvenienti della tecnica nota, con efficacia sia sul viso, che sul collo con risultati esteticamente validi e duraturi nel tempo. The main object of the present invention is to provide a dermocosmetic cream with a tensor effect, capable of overcoming the drawbacks of the known art, effectively both on the face and on the neck with aesthetically valid and long-lasting results.
Un altro scopo è quello di fornire un prodotto che sia privo di appiccicosità, non provochi effetti indesiderati dopo il trattamento come, ad esempio, secchezza cutanea, arrossamento cutaneo, anallergico e con ingredienti derivanti da materie prime di agricoltura biologica. Another object is to provide a product which is free from stickiness, does not cause undesirable effects after treatment such as, for example, skin dryness, skin redness, hypoallergenic and with ingredients deriving from organic farming raw materials.
Ancora uno scopo è quello di fornire un prodotto non testato sugli animali che sia facile da preparare ed economico. Another object is to provide a product not tested on animals which is easy to prepare and economical.
Questi scopi, ed ulteriori, che meglio risulteranno dalla descrizione particolareggiata che segue, sono raggiunti dalla crema dermocosmetica antiinvecchiamento, comprendente un principio attivo che si è rilevato particolarmente efficace nel rallentamento dei processi cellulari che stanno alla base dell’invecchiamento cellulare della cute del viso e del collo, e nella stimolazione dei processi che hanno come risultato finale la rigenerazione cellulare. These and further purposes, which will better emerge from the detailed description that follows, are achieved by the anti-aging dermocosmetic cream, comprising an active ingredient which has been found to be particularly effective in slowing down the cellular processes underlying the cellular aging of the skin of the face and of the neck, and in the stimulation of the processes that result in cell regeneration.
Forma pertanto oggetto della presente invenzione una composizione dermocosmetica avente le caratteristiche indicate nelle rivendicazioni allegate. Therefore, the subject of the present invention is a dermocosmetic composition having the characteristics indicated in the attached claims.
La presente invenzione ad effetto lifting comprende come principio attivo principale la citicolina, sotto forma di fosfatidilcolina e la vitamina A sotto forma di liposomi di vitamina A. The present invention with a lifting effect comprises citicoline as its main active ingredient, in the form of phosphatidylcholine and vitamin A in the form of vitamin A liposomes.
La citicolina, anche conosciuta come CDP-colina o citidin 5'-difosfocolina, è una particolare molecola dotata di attività psicostimolante e nootropa, ossia è in grado di incrementare le capacità cognitive dell'individuo. Per tale ragione, l'uso della citicolina, fino ad oggi, ha trovato impiego soprattutto come trattamento di supporto in caso di disturbi e affezioni cerebrovascolari che possono causare alterazioni delle suddette capacità. Citicoline, also known as CDP-choline or cytidin 5'-diphosphocholine, is a particular molecule with psychostimulating and nootropic activity, that is, it is able to increase the cognitive abilities of the individual. For this reason, the use of citicoline, up to now, has found use above all as a support treatment in case of cerebrovascular disorders and affections that can cause alterations of the aforementioned abilities.
Da studi effettuati dal richiedente, è risultato che l’utilizzo della citicolina come principio attivo in una crema, sotto forma di fosfatidilcolina per facilitarne l’assorbimento cutaneo è particolarmente idoneo al trattamento ed al contrasto della formazione delle rughe e degli altri inestetismi cutanei che risultano dall’invecchiamento della pelle. From studies carried out by the applicant, it was found that the use of citicoline as an active ingredient in a cream, in the form of phosphatidylcholine to facilitate skin absorption, is particularly suitable for treating and contrasting the formation of wrinkles and other skin imperfections that result. from skin aging.
Questi ed altri scopi, come meglio appariranno dalla descrizione che segue, sono raggiunti dalla crema dermocosmetica oggetto della presente invenzione che viene descritta nel seguito, in un’esecuzione preferita, non limitativa di ulteriori sviluppi nell’ambito dell’invenzione medesima. These and other purposes, as will become clearer from the following description, are achieved by the dermocosmetic cream object of the present invention which is described below, in a preferred embodiment, not limiting further developments within the same invention.
La citicolina è un intermedio essenziale nella via biosintetica della fosfatidilcolina. Essa interviene regolando la via biosintetica della fosfatidilcolina che costituisce il lipide più abbondante nel foglietto esterno delle membrane plasmatiche delle cellule umane. La membrana citoplasmatica rappresenta la prima barriera di difesa ed eventuali sue alterazioni si rifletteranno anche in danni intracellulari per le cellule e conseguentemente nell’invecchiamento cellulare. Citicoline is an essential intermediate in the biosynthetic pathway of phosphatidylcholine. It intervenes by regulating the biosynthetic pathway of phosphatidylcholine which is the most abundant lipid in the outer layer of the plasma membranes of human cells. The cytoplasmic membrane represents the first defense barrier and any alterations thereof will also be reflected in intracellular damage to the cells and consequently in cellular aging.
L’invecchiamento cellulare è dovuto a tanti fattori di stress interni ed esterni. Cellular aging is due to many internal and external stress factors.
L’età, i numerosi anni di esposizione ad agenti stressanti esterni quali raggi UV, gli sbalzi termici ecc, causano danni alla cute che comportano rughe e linee di espressione profonde, colorito irregolare e perdita di tonicità sempre più evidente. Age, the many years of exposure to external stressors such as UV rays, temperature changes, etc., cause damage to the skin that lead to wrinkles and deep expression lines, uneven complexion and increasingly evident loss of tone.
L’assorbimento per via cutanea della citicolina sotto forma di fosfatidilcolina offrirà verosimilmente alle cellule la materia prima per riparare le alterazioni della membrana cellulare e del sistema di membrane interne che altrettanto contengono il lipide della fosfatidilcolina, con il risultato di rallentare il processo di invecchiamento cellulare e di stimolare la rigenerazione cellulare della cute nell’insieme dei suoi strati donando un effetto lifting finale. The cutaneous absorption of citicoline in the form of phosphatidylcholine will likely offer the cells the raw material to repair the alterations of the cell membrane and the internal membrane system which also contain the phosphatidylcholine lipid, with the result of slowing down the cellular aging process. and to stimulate the cellular regeneration of the skin in all its layers giving a final lifting effect.
La citicolina sotto forma di fosfatidilcolina in percentuale variabile ma nei giusti dosaggi, con l'aggiunta della vitamina A sotto forma di liposomi di vitamina A migliora la performance della citicolina nel contrastare l’invecchiamento cellulare e nello stimolare la rigenerazione cellulare migliorando l’assorbimento da parte della cute dei principali principi attivi della crema. Citicoline in the form of phosphatidylcholine in variable percentages but in the right dosages, with the addition of vitamin A in the form of vitamin A liposomes, improves the performance of citicoline in counteracting cellular aging and stimulating cell regeneration by improving absorption from part of the skin of the main active ingredients of the cream.
La crema dermocosmetica, di cui alla presente invenzione, è composta dal principio attivo di fosfatidilcolina al 10 % ± 2 % e Vitamina A 2% ± 1 %. The dermocosmetic cream, according to the present invention, is composed of the active principle of phosphatidylcholine at 10% ± 2% and Vitamin A 2% ± 1%.
Una composizione tipo della crema dermocosmetica secondo la presente invenzione, prevede la seguente formulazione: A typical composition of the dermocosmetic cream according to the present invention provides the following formulation:
- 10% Fosfatidilcolina; - 10% Phosphatidylcholine;
- 1% Vitamina A; - 1% Vitamin A;
- 89 % Eccipienti. - 89% Excipients.
Una composizione per un trattamento più intensivo può prevedere la seguente formulazione: A composition for a more intensive treatment can include the following formulation:
- 12 % Fosfatidilcolina; - 12% Phosphatidylcholine;
- 3 % Vitamina A; - 3% Vitamin A;
- 85 % Eccipienti. - 85% Excipients.
Gli eccipienti della crema a base di Fosfatidilcolina e Vitamina A sono suscettibili a numerose modifiche a seconda delle esigenze, tutte rientranti nel concetto inventivo in quanto creano solo la base del cosmetico. The excipients of the cream based on Phosphatidylcholine and Vitamin A are susceptible to numerous modifications according to the needs, all falling within the inventive concept as they only create the basis of the cosmetic.
Si procede, nel seguito, a descrivere le modalità d’uso della crema dermocosmetica di cui alla presente invenzione. We proceed, below, to describe the methods of use of the dermocosmetic cream referred to in the present invention.
Prima dell’applicazione, si consiglia una pulizia della cute, in modo da evitare l'interposizione di altri tipi di sostanze tra il prodotto e la pelle da trattare, in quanto faciliterà la distensione e l'assorbimento del prodotto. Applicare una piccola dose di prodotto sulle zone da trattare e procedere al massaggio fino a completo assorbimento. Before application, we recommend cleaning the skin, in order to avoid the interposition of other types of substances between the product and the skin to be treated, as it will facilitate the relaxation and absorption of the product. Apply a small amount of product on the areas to be treated and proceed with the massage until completely absorbed.
È consigliabile l'utilizzo quotidiano della crema ad effetto lifting con un'applicazione sul viso e decolté nelle ore serali. It is advisable to use the lifting effect cream daily with an application on the face and décolleté in the evening.
Inoltre, è consigliabile utilizzare il dosaggio minimo del prodotto, in quanto si è constatato che la somministrazione di un dosaggio maggiore non determina nessun tipo di miglioramento aggiuntivo, nel contrastare l’invecchiamento della pelle e degli inestetismi che da essi derivino. In addition, it is advisable to use the minimum dosage of the product, as it has been found that the administration of a higher dosage does not lead to any kind of additional improvement, in contrasting skin aging and the imperfections that derive from them.
È possibile osservare i primi risultati dopo una settimana di trattamento. The first results can be seen after a week of treatment.
È stato osservato che la sua applicazione giornaliera determina non solo un ringiovanimento della cute con l’appianamento delle rughe, ma anche la scomparsa delle macchie cutanee e di altri inestetismi dovuti all'età donando un effetto lifting finale. It has been observed that its daily application determines not only skin rejuvenation with the smoothing of wrinkles, but also the disappearance of skin spots and other age-related imperfections, giving a final lifting effect.
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000009564A IT201900009564A1 (en) | 2019-06-20 | 2019-06-20 | "ANTI-AGING DERMOCOSMETIC CREAM" |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000009564A IT201900009564A1 (en) | 2019-06-20 | 2019-06-20 | "ANTI-AGING DERMOCOSMETIC CREAM" |
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| Publication Number | Publication Date |
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| IT201900009564A1 true IT201900009564A1 (en) | 2020-12-20 |
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| IT102019000009564A IT201900009564A1 (en) | 2019-06-20 | 2019-06-20 | "ANTI-AGING DERMOCOSMETIC CREAM" |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007051614A1 (en) * | 2007-10-24 | 2009-04-30 | Coty Prestige Lancaster Group Gmbh | Retinol-containing cosmetic product |
| EP2113241A2 (en) * | 2008-04-29 | 2009-11-04 | Coty Prestige Lancaster Group GmbH | Cosmetic product with delayed retinol release |
| CN108498346A (en) * | 2018-05-14 | 2018-09-07 | 哈尔滨华辰美容化妆品有限公司 | A kind of liposomes structure, ingredient and preparation method for realizing skin cleaning anti-aging |
-
2019
- 2019-06-20 IT IT102019000009564A patent/IT201900009564A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007051614A1 (en) * | 2007-10-24 | 2009-04-30 | Coty Prestige Lancaster Group Gmbh | Retinol-containing cosmetic product |
| EP2113241A2 (en) * | 2008-04-29 | 2009-11-04 | Coty Prestige Lancaster Group GmbH | Cosmetic product with delayed retinol release |
| CN108498346A (en) * | 2018-05-14 | 2018-09-07 | 哈尔滨华辰美容化妆品有限公司 | A kind of liposomes structure, ingredient and preparation method for realizing skin cleaning anti-aging |
Non-Patent Citations (5)
| Title |
|---|
| ANONYMOUS: "Phosphatidylcholine", 1 January 2019 (2019-01-01), XP055668174, Retrieved from the Internet <URL:https://www.truthinaging.com/ingredients/phosphatidylcholine> [retrieved on 20200213] * |
| DATABASE GNPD [online] MINTEL; 6 October 2016 (2016-10-06), ANONYMOUS: "Anti-Aging Treatment", XP055666310, retrieved from www.gnpd.com Database accession no. 4316531 * |
| ELIZABETH TRINGALI: "Phosphatidylcholine: The Miracle Molecule - Tringali Vibrant Health", 11 June 2018 (2018-06-11), XP055668218, Retrieved from the Internet <URL:https://tringali-health.com/new-posts/phosphatidylcholine-wake-up-your-brain/> [retrieved on 20200213] * |
| MARION TIBLE: "Lécithine, phosphatidylcholine et santé cardiovasculaire - Work for human longevity", 25 May 2018 (2018-05-25), XP055668183, Retrieved from the Internet <URL:http://www.longlonglife.org/fr/transhumanisme-longevite/complements-anti-vieillissement/lecithine-phosphatidylcholine-et-sante-cardiovasculaire/> [retrieved on 20200213] * |
| P VAN HOOGEVEST ET AL: "Phospholipids: Natural Functional Ingredients and Actives for Cosmetic Products", SOFW-JOURNAL, vol. 139, 1 January 2013 (2013-01-01), pages 9 - 14, XP055668170 * |
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