IT1235045B - New amino anthracene-di:one(s)-bis platinum complexes - Google Patents

New amino anthracene-di:one(s)-bis platinum complexes

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Publication number
IT1235045B
IT1235045B IT8848492A IT4849288A IT1235045B IT 1235045 B IT1235045 B IT 1235045B IT 8848492 A IT8848492 A IT 8848492A IT 4849288 A IT4849288 A IT 4849288A IT 1235045 B IT1235045 B IT 1235045B
Authority
IT
Italy
Prior art keywords
ch3soch3
ch2ch2o
alkoxy
alkyl
platinum complexes
Prior art date
Application number
IT8848492A
Other languages
Italian (it)
Other versions
IT8848492A0 (en
Inventor
Pasini Alessandro
Zunino Franco
Tofanetti Odoardo
Carmelo A Gandolfi
Tognella Sergio
Spinelli Silvano
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Publication of IT8848492A0 publication Critical patent/IT8848492A0/en
Priority to IT8848492A priority Critical patent/IT1235045B/en
Priority to AU28175/89A priority patent/AU2817589A/en
Priority to JP1500325A priority patent/JPH03503046A/en
Priority to EP89900592A priority patent/EP0396588A1/en
Priority to US07/499,405 priority patent/US5145848A/en
Priority to PCT/EP1988/001110 priority patent/WO1989005815A1/en
Priority to CA000586002A priority patent/CA1327355C/en
Priority to ES88121072T priority patent/ES2056887T3/en
Priority to EP88121072A priority patent/EP0320960B1/en
Priority to DE88121072T priority patent/DE3880991T2/en
Priority to AT88121072T priority patent/ATE89284T1/en
Application granted granted Critical
Publication of IT1235045B publication Critical patent/IT1235045B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Amino anthracenediones-bis platinum complexes of formula (I) and their non-toxic and acid salts are new: where X,X1 = ligands selected from Cl, Br, OH, CH3SOCH3.Cl, CH3SOCH3.Br, CH3SOCH3.OH; or X+X1 = anion of a linear or cyclic opt. substd. dicarboxylic acid; m = 0, 0.5 or 1-5; Solv = solvent of crystallisation selected from water, 1-5C alcohols, acetonitrile and ethylacetate; A = a disubstd. 1,4-anthracenedione of formula (i) Rc,Rd = H or OH; Rb = 1-6C alkyl opt. substd. by OH, 1-3C alkoxy, 2-8C polyalkoxy on sulphonic gp.; mono-amino-sugar in acetalic or linear form of formulae (a) or (b) resp.: R1 = H, 1-3C alkyl, hydroxymethyl or aminomethyl; R2-R4 = NH2, OH or H; provided that at least one of R2-R4 = H and only one of R1,R2 or R3 = NH2; R5 = OH, 1-3C alkoxy or benzyloxy; when R5 = OH, (a) and (b) represent the same structure where the cyclic hemiacetalic form and the opened aldehydic form are in equilibirum; when R5 = alkoxy or benzyloxy, it can be an alpha or a beta-oloside. Ra = H, 1-5C alkyl, (CH2CH2O)pH, (CH2CH2O)pOCH3, (CH2CH2O)pC2H5; n = 2-3; p = 1-6.
IT8848492A 1987-12-18 1988-10-26 New amino anthracene-di:one(s)-bis platinum complexes IT1235045B (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT8848492A IT1235045B (en) 1988-10-26 1988-10-26 New amino anthracene-di:one(s)-bis platinum complexes
US07/499,405 US5145848A (en) 1987-12-18 1988-12-07 Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
JP1500325A JPH03503046A (en) 1987-12-18 1988-12-07 Aminoanthracenedione-bisplatinum complex useful as an antitumor agent
EP89900592A EP0396588A1 (en) 1987-12-18 1988-12-07 Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
AU28175/89A AU2817589A (en) 1987-12-18 1988-12-07 Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
PCT/EP1988/001110 WO1989005815A1 (en) 1987-12-18 1988-12-07 Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
CA000586002A CA1327355C (en) 1987-12-18 1988-12-15 Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
ES88121072T ES2056887T3 (en) 1987-12-18 1988-12-16 AMINO-ANTRACENODIONA-BIS-PLATINUM COMPLEXES, USEFUL AS ANTITUMORAL AGENTS.
EP88121072A EP0320960B1 (en) 1987-12-18 1988-12-16 Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
DE88121072T DE3880991T2 (en) 1987-12-18 1988-12-16 Aminoanthracenedione bis-platinum complexes, useful as anti-tumor agents.
AT88121072T ATE89284T1 (en) 1987-12-18 1988-12-16 AMINOANTHRACENDIONE BIS PLATINUM COMPLEXES, USEFUL AS ANTITUMORS AGENTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8848492A IT1235045B (en) 1988-10-26 1988-10-26 New amino anthracene-di:one(s)-bis platinum complexes

Publications (2)

Publication Number Publication Date
IT8848492A0 IT8848492A0 (en) 1988-10-26
IT1235045B true IT1235045B (en) 1992-06-17

Family

ID=11266893

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8848492A IT1235045B (en) 1987-12-18 1988-10-26 New amino anthracene-di:one(s)-bis platinum complexes

Country Status (1)

Country Link
IT (1) IT1235045B (en)

Also Published As

Publication number Publication date
IT8848492A0 (en) 1988-10-26

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