IT1224142B - Forma delta cristallina, stabile, anidra di idrocloruro di prazosin e nuovo procedimento per la preparazione di detta forma delta cristallina - Google Patents

Forma delta cristallina, stabile, anidra di idrocloruro di prazosin e nuovo procedimento per la preparazione di detta forma delta cristallina

Info

Publication number
IT1224142B
IT1224142B IT23292/84A IT2329284A IT1224142B IT 1224142 B IT1224142 B IT 1224142B IT 23292/84 A IT23292/84 A IT 23292/84A IT 2329284 A IT2329284 A IT 2329284A IT 1224142 B IT1224142 B IT 1224142B
Authority
IT
Italy
Prior art keywords
delta
crystalline
stable
preparation
new procedure
Prior art date
Application number
IT23292/84A
Other languages
English (en)
Italian (it)
Other versions
IT8423292A0 (it
Inventor
Stig Olof Engelbert Lindholm
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of IT8423292A0 publication Critical patent/IT8423292A0/it
Application granted granted Critical
Publication of IT1224142B publication Critical patent/IT1224142B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IT23292/84A 1984-06-25 1984-10-24 Forma delta cristallina, stabile, anidra di idrocloruro di prazosin e nuovo procedimento per la preparazione di detta forma delta cristallina IT1224142B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI842544A FI79107C (fi) 1984-06-25 1984-06-25 Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.

Publications (2)

Publication Number Publication Date
IT8423292A0 IT8423292A0 (it) 1984-10-24
IT1224142B true IT1224142B (it) 1990-09-26

Family

ID=8519293

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23292/84A IT1224142B (it) 1984-06-25 1984-10-24 Forma delta cristallina, stabile, anidra di idrocloruro di prazosin e nuovo procedimento per la preparazione di detta forma delta cristallina

Country Status (17)

Country Link
US (2) US4739055A (cg-RX-API-DMAC7.html)
JP (1) JPS6115881A (cg-RX-API-DMAC7.html)
AT (1) AT389117B (cg-RX-API-DMAC7.html)
AU (1) AU566814B2 (cg-RX-API-DMAC7.html)
BE (1) BE900925A (cg-RX-API-DMAC7.html)
CH (1) CH661045A5 (cg-RX-API-DMAC7.html)
DE (1) DE3429415A1 (cg-RX-API-DMAC7.html)
FI (1) FI79107C (cg-RX-API-DMAC7.html)
FR (1) FR2567124B1 (cg-RX-API-DMAC7.html)
GB (1) GB2160861B (cg-RX-API-DMAC7.html)
IL (1) IL73267A (cg-RX-API-DMAC7.html)
IT (1) IT1224142B (cg-RX-API-DMAC7.html)
LU (1) LU85616A1 (cg-RX-API-DMAC7.html)
NL (1) NL8403250A (cg-RX-API-DMAC7.html)
NZ (1) NZ209962A (cg-RX-API-DMAC7.html)
PT (1) PT79411B (cg-RX-API-DMAC7.html)
ZA (1) ZA85910B (cg-RX-API-DMAC7.html)

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DE3683760D1 (de) * 1986-03-21 1992-03-12 Heumann Pharma Gmbh & Co Kristalline, wasserfreie sigma -form von 2-(4-(2-furoyl-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung.
JP2756846B2 (ja) * 1989-12-28 1998-05-25 住化ファインケム株式会社 無水のε型結晶体２―〔４―（２―フロイル）ピペラジン―１―イル〕―４―アミノ―６，７―ジメトキシキナゾリン塩酸塩及びその製造方法
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
DK1757606T3 (da) * 2001-02-24 2009-09-07 Boehringer Ingelheim Pharma Anvendelse af xanthinderivater som l gemidler samt fremgangsm de til deres fremstilling
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) * 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
JP5323684B2 (ja) * 2006-05-04 2013-10-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 多形体
PE20080251A1 (es) * 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
AU2008290582B2 (en) * 2007-08-17 2014-08-14 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
EP2326326B1 (en) * 2008-08-15 2019-10-09 Boehringer Ingelheim International GmbH Dpp-4 inhibitors for use for the treatment of wound healing in diabetic patients
JP2012502081A (ja) 2008-09-10 2012-01-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連症状の治療のための組み合わせ治療
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
TWI508965B (zh) 2008-12-23 2015-11-21 Boehringer Ingelheim Int 有機化合物的鹽形式
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
KR20190071840A (ko) 2009-11-27 2019-06-24 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
MX366325B (es) 2010-05-05 2019-07-05 Boehringer Ingelheim Int Terapia de combinacion.
CA2803504C (en) 2010-06-24 2022-08-30 Boehringer Ingelheim International Gmbh A combination for diabetes therapy comprising linagliptin and a long-acting insulin
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
KR101985384B1 (ko) 2011-07-15 2019-06-03 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴나졸린, 이의 제조 및 약제학적 조성물에서의 이의 용도
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP6218811B2 (ja) 2012-05-14 2017-10-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
BR112018072401A2 (pt) 2016-06-10 2019-02-19 Boehringer Ingelheim International Gmbh combinações de linagliptina e metformina

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US2969375A (en) * 1961-01-24 Certification of correction
DE156532C (cg-RX-API-DMAC7.html) *
BE427505A (cg-RX-API-DMAC7.html) * 1937-05-25
GB1156973A (en) * 1965-07-06 1969-07-02 Quinazoline Derivatives
US3433788A (en) * 1966-04-27 1969-03-18 Union Carbide Corp Process for recovery of amines from aqueous solutions by solvent treatment and distillation
US3421983A (en) * 1967-03-07 1969-01-14 Lummus Co Azeotropic distillation of aqueous toluene diamine
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3743672A (en) * 1970-05-27 1973-07-03 Halcon International Inc Separation of water in alkylene glycol mono and diester purification by azeotropic distillation
GB1308718A (en) * 1970-07-01 1973-03-07 Sir Soc Italiana Resine Spa Method of separating vinyl acetate from liquid mixtures
IT956765B (it) * 1972-06-22 1973-10-10 Montedison Spa Procedimento per la purificazione di 1 3 diossolano
US3935213A (en) * 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4092315A (en) * 1976-03-01 1978-05-30 Pfizer Inc. Novel crystalline forms of prazosin hydrochloride
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
FI64367C (fi) * 1980-02-26 1986-08-05 Orion Yhtymae Oy Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid

Also Published As

Publication number Publication date
GB8424999D0 (en) 1984-11-07
CH661045A5 (de) 1987-06-30
NL8403250A (nl) 1986-01-16
FI842544A0 (fi) 1984-06-25
AU3451084A (en) 1986-01-02
FI79107B (fi) 1989-07-31
BE900925A (fr) 1985-02-15
FI79107C (fi) 1989-11-10
AU566814B2 (en) 1987-10-29
LU85616A1 (fr) 1985-06-04
ZA85910B (en) 1985-09-25
IT8423292A0 (it) 1984-10-24
IL73267A (en) 1988-06-30
JPS6115881A (ja) 1986-01-23
US4873330A (en) 1989-10-10
AT389117B (de) 1989-10-25
ATA344184A (de) 1989-03-15
IL73267A0 (en) 1985-01-31
PT79411B (en) 1986-09-15
US4739055A (en) 1988-04-19
FI842544L (fi) 1985-12-26
FR2567124A1 (fr) 1986-01-10
PT79411A (en) 1984-11-01
DE3429415A1 (de) 1986-01-02
DE3429415C2 (cg-RX-API-DMAC7.html) 1990-05-03
GB2160861B (en) 1987-11-18
JPH0481993B2 (cg-RX-API-DMAC7.html) 1992-12-25
NZ209962A (en) 1987-06-30
GB2160861A (en) 1986-01-02
FR2567124B1 (fr) 1990-09-21

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