IT1202739B - 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst - Google Patents
4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalystInfo
- Publication number
- IT1202739B IT1202739B IT2087478A IT2087478A IT1202739B IT 1202739 B IT1202739 B IT 1202739B IT 2087478 A IT2087478 A IT 2087478A IT 2087478 A IT2087478 A IT 2087478A IT 1202739 B IT1202739 B IT 1202739B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- alkanoyl
- corresp
- friedel
- alkanoylating
- Prior art date
Links
- 238000005727 Friedel-Crafts reaction Methods 0.000 title abstract 2
- 239000003054 catalyst Substances 0.000 title abstract 2
- 238000005618 Fries rearrangement reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
4-Alkyl-6 (or 8)-alkanoyl-7-hydroxycoumarins of formula (I):- (where R is unsubstd. alkyl; and R1 is alkanoyl ortho to the 7-OH) are prepd. by reacting a corresp. 4-alkyl-7-hydroxycoumarin (II) with an alkanoylating agent in presence of a Friedel-crafts catalyst. Good yields of (I) in a simple process compared with the previously used Fries rearrangement; (I) are intermediates for pharmacologically active cpds.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2087478A IT1202739B (en) | 1978-03-03 | 1978-03-03 | 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2087478A IT1202739B (en) | 1978-03-03 | 1978-03-03 | 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7820874A0 IT7820874A0 (en) | 1978-03-03 |
IT1202739B true IT1202739B (en) | 1989-02-09 |
Family
ID=11173372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2087478A IT1202739B (en) | 1978-03-03 | 1978-03-03 | 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1202739B (en) |
-
1978
- 1978-03-03 IT IT2087478A patent/IT1202739B/en active
Also Published As
Publication number | Publication date |
---|---|
IT7820874A0 (en) | 1978-03-03 |
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