FR2419942A1 - 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst - Google Patents

4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst

Info

Publication number
FR2419942A1
FR2419942A1 FR7807168A FR7807168A FR2419942A1 FR 2419942 A1 FR2419942 A1 FR 2419942A1 FR 7807168 A FR7807168 A FR 7807168A FR 7807168 A FR7807168 A FR 7807168A FR 2419942 A1 FR2419942 A1 FR 2419942A1
Authority
FR
France
Prior art keywords
alkyl
alkanoyl
corresp
friedel
alkanoylating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7807168A
Other languages
French (fr)
Other versions
FR2419942B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Priority to FR7807168A priority Critical patent/FR2419942A1/en
Publication of FR2419942A1 publication Critical patent/FR2419942A1/en
Application granted granted Critical
Publication of FR2419942B1 publication Critical patent/FR2419942B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Abstract

4-Alkyl-6 (or 8)-alkanoyl-7-hydroxycoumarins of formula (I):- (where R is unsubstd. alkyl; and R1 is alkanoyl ortho to the 7-OH) are prepd. by reacting a corresp. 4-alkyl-7-hydroxycoumarin (II) with an alkanoylating agent in presence of a Friedel-crafts catalyst. Good yields of (I) in a simple process compared with the previously used Fries rearrangement; (I) are intermediates for pharmacologically active cpds.
FR7807168A 1978-03-13 1978-03-13 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst Granted FR2419942A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7807168A FR2419942A1 (en) 1978-03-13 1978-03-13 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7807168A FR2419942A1 (en) 1978-03-13 1978-03-13 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst

Publications (2)

Publication Number Publication Date
FR2419942A1 true FR2419942A1 (en) 1979-10-12
FR2419942B1 FR2419942B1 (en) 1982-12-31

Family

ID=9205690

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7807168A Granted FR2419942A1 (en) 1978-03-13 1978-03-13 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst

Country Status (1)

Country Link
FR (1) FR2419942A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1559722A (en) * 1966-12-22 1969-03-14

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1559722A (en) * 1966-12-22 1969-03-14

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/64 *

Also Published As

Publication number Publication date
FR2419942B1 (en) 1982-12-31

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