FR2419942A1 - 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst - Google Patents
4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalystInfo
- Publication number
- FR2419942A1 FR2419942A1 FR7807168A FR7807168A FR2419942A1 FR 2419942 A1 FR2419942 A1 FR 2419942A1 FR 7807168 A FR7807168 A FR 7807168A FR 7807168 A FR7807168 A FR 7807168A FR 2419942 A1 FR2419942 A1 FR 2419942A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- alkanoyl
- corresp
- friedel
- alkanoylating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
4-Alkyl-6 (or 8)-alkanoyl-7-hydroxycoumarins of formula (I):- (where R is unsubstd. alkyl; and R1 is alkanoyl ortho to the 7-OH) are prepd. by reacting a corresp. 4-alkyl-7-hydroxycoumarin (II) with an alkanoylating agent in presence of a Friedel-crafts catalyst. Good yields of (I) in a simple process compared with the previously used Fries rearrangement; (I) are intermediates for pharmacologically active cpds.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7807168A FR2419942A1 (en) | 1978-03-13 | 1978-03-13 | 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7807168A FR2419942A1 (en) | 1978-03-13 | 1978-03-13 | 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2419942A1 true FR2419942A1 (en) | 1979-10-12 |
FR2419942B1 FR2419942B1 (en) | 1982-12-31 |
Family
ID=9205690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7807168A Granted FR2419942A1 (en) | 1978-03-13 | 1978-03-13 | 4-Alkyl-alkanoyl-7-hydroxy-coumarin prepn. in good yield - by alkanoylating corresp. unsubstituted cpd. using Friedel-Crafts catalyst |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2419942A1 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1559722A (en) * | 1966-12-22 | 1969-03-14 |
-
1978
- 1978-03-13 FR FR7807168A patent/FR2419942A1/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1559722A (en) * | 1966-12-22 | 1969-03-14 |
Non-Patent Citations (1)
Title |
---|
EXBK/64 * |
Also Published As
Publication number | Publication date |
---|---|
FR2419942B1 (en) | 1982-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |