IT1197033B - Analoghi di ammide-tioammide prostaglandina 7 ossabicicloeptano sostituiti - Google Patents
Analoghi di ammide-tioammide prostaglandina 7 ossabicicloeptano sostituitiInfo
- Publication number
- IT1197033B IT1197033B IT21342/86A IT2134286A IT1197033B IT 1197033 B IT1197033 B IT 1197033B IT 21342/86 A IT21342/86 A IT 21342/86A IT 2134286 A IT2134286 A IT 2134286A IT 1197033 B IT1197033 B IT 1197033B
- Authority
- IT
- Italy
- Prior art keywords
- oxabycyleptane
- amalog
- thioamide
- prostaglandin
- replaced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/761,261 US4654355A (en) | 1985-08-01 | 1985-08-01 | 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs |
Publications (3)
Publication Number | Publication Date |
---|---|
IT8621342A0 IT8621342A0 (it) | 1986-07-31 |
IT8621342A1 IT8621342A1 (it) | 1988-01-31 |
IT1197033B true IT1197033B (it) | 1988-11-25 |
Family
ID=25061678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT21342/86A IT1197033B (it) | 1985-08-01 | 1986-07-31 | Analoghi di ammide-tioammide prostaglandina 7 ossabicicloeptano sostituiti |
Country Status (7)
Country | Link |
---|---|
US (1) | US4654355A (it) |
JP (1) | JPS6233181A (it) |
CA (1) | CA1285569C (it) |
DE (1) | DE3625870A1 (it) |
FR (1) | FR2585703B1 (it) |
GB (1) | GB2178430B (it) |
IT (1) | IT1197033B (it) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH038636A (ja) * | 1989-06-07 | 1991-01-16 | Delphi Co Ltd | 分離送り装置 |
US5290799A (en) * | 1990-09-19 | 1994-03-01 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
US20090018142A9 (en) * | 2006-05-02 | 2009-01-15 | Zhengping Zhuang | Use of phosphatases to treat tumors overexpressing N-CoR |
KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(rap)-접합체 투여에 의한 간 질환의 치료 |
CN101662939B (zh) | 2007-02-06 | 2015-11-25 | 利克斯特生物技术公司 | 氧杂双环庚烷和氧杂双环庚烯,它们的制备及用途 |
CA2718472A1 (en) * | 2007-08-03 | 2009-02-12 | Lixte Biotechnology, Inc. | Use of phosphatases to treat neuroblastomas and medulloblastomas |
EP2200439B1 (en) | 2007-10-01 | 2017-03-22 | Lixte Biotechnology, Inc. | Hdac inhibitors |
US8227473B2 (en) * | 2008-08-01 | 2012-07-24 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
AU2009277086B2 (en) * | 2008-08-01 | 2015-12-10 | Lixte Biotechnology, Inc. | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases |
WO2010147612A1 (en) | 2009-06-18 | 2010-12-23 | Lixte Biotechnology, Inc. | Methods of modulating cell regulation by inhibiting p53 |
CA2730428A1 (en) * | 2008-08-01 | 2010-02-04 | Lixte Biotechnology, Inc. | Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase |
PT2398500T (pt) | 2009-02-20 | 2019-06-14 | 2 Bbb Medicines B V | Sistema de entrega de medicamentos à base de glutationas |
TWI556839B (zh) | 2009-05-06 | 2016-11-11 | 研究室護膚股份有限公司 | 包含活性劑-磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
EP2983661B1 (en) | 2013-04-09 | 2024-05-29 | Lixte Biotechnology, Inc. | Formulations of oxabicycloheptanes and oxabicycloheptenes |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4254044A (en) * | 1977-11-04 | 1981-03-03 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds |
US4187236A (en) * | 1977-11-04 | 1980-02-05 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane compounds |
US4220594A (en) * | 1977-11-04 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol |
US4143054A (en) * | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
WO1980001381A1 (en) * | 1979-01-05 | 1980-07-10 | R Jones | Substituted bicyclo (2,2,1) heptanes and hept-2-enes |
US4228180A (en) * | 1979-11-01 | 1980-10-14 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs |
ZA829068B (en) * | 1980-07-01 | 1983-02-23 | Nat Res Dev | Prostaglandins |
US4416896A (en) * | 1982-05-17 | 1983-11-22 | E. R. Squibb & Sons, Inc. | 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease |
US4456615A (en) * | 1982-10-25 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
US4456617A (en) * | 1983-01-12 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
US4525479A (en) * | 1983-08-29 | 1985-06-25 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs useful as cardiovascular agents |
US4526901A (en) * | 1984-01-26 | 1985-07-02 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted oxamide prostaglandin analogs and their use in treating thrombolytic disease |
-
1985
- 1985-08-01 US US06/761,261 patent/US4654355A/en not_active Expired - Fee Related
-
1986
- 1986-07-31 GB GB8618698A patent/GB2178430B/en not_active Expired
- 1986-07-31 DE DE19863625870 patent/DE3625870A1/de not_active Withdrawn
- 1986-07-31 FR FR8611126A patent/FR2585703B1/fr not_active Expired
- 1986-07-31 CA CA000515053A patent/CA1285569C/en not_active Expired - Lifetime
- 1986-07-31 JP JP61181841A patent/JPS6233181A/ja active Pending
- 1986-07-31 IT IT21342/86A patent/IT1197033B/it active
Also Published As
Publication number | Publication date |
---|---|
IT8621342A1 (it) | 1988-01-31 |
US4654355A (en) | 1987-03-31 |
JPS6233181A (ja) | 1987-02-13 |
CA1285569C (en) | 1991-07-02 |
IT8621342A0 (it) | 1986-07-31 |
GB2178430A (en) | 1987-02-11 |
DE3625870A1 (de) | 1987-02-05 |
FR2585703A1 (fr) | 1987-02-06 |
GB2178430B (en) | 1989-04-26 |
GB8618698D0 (en) | 1986-09-10 |
FR2585703B1 (fr) | 1988-08-19 |
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