IT8621342A1 - Analoghi di ammide-tioammide prostaglandina 7-ossabicicloeptano sostituiti - Google Patents

Analoghi di ammide-tioammide prostaglandina 7-ossabicicloeptano sostituiti

Info

Publication number
IT8621342A1
IT8621342A1 IT1986A21342A IT2134286A IT8621342A1 IT 8621342 A1 IT8621342 A1 IT 8621342A1 IT 1986A21342 A IT1986A21342 A IT 1986A21342A IT 2134286 A IT2134286 A IT 2134286A IT 8621342 A1 IT8621342 A1 IT 8621342A1
Authority
IT
Italy
Prior art keywords
oxabicycloheptane
amide
substituted prostaglandin
thioamide analogs
thioamide
Prior art date
Application number
IT1986A21342A
Other languages
English (en)
Other versions
IT8621342A0 (it
IT1197033B (it
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8621342A0 publication Critical patent/IT8621342A0/it
Publication of IT8621342A1 publication Critical patent/IT8621342A1/it
Application granted granted Critical
Publication of IT1197033B publication Critical patent/IT1197033B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT21342/86A 1985-08-01 1986-07-31 Analoghi di ammide-tioammide prostaglandina 7 ossabicicloeptano sostituiti IT1197033B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/761,261 US4654355A (en) 1985-08-01 1985-08-01 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs

Publications (3)

Publication Number Publication Date
IT8621342A0 IT8621342A0 (it) 1986-07-31
IT8621342A1 true IT8621342A1 (it) 1988-01-31
IT1197033B IT1197033B (it) 1988-11-25

Family

ID=25061678

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21342/86A IT1197033B (it) 1985-08-01 1986-07-31 Analoghi di ammide-tioammide prostaglandina 7 ossabicicloeptano sostituiti

Country Status (7)

Country Link
US (1) US4654355A (it)
JP (1) JPS6233181A (it)
CA (1) CA1285569C (it)
DE (1) DE3625870A1 (it)
FR (1) FR2585703B1 (it)
GB (1) GB2178430B (it)
IT (1) IT1197033B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH038636A (ja) * 1989-06-07 1991-01-16 Delphi Co Ltd 分離送り装置
US5290799A (en) * 1990-09-19 1994-03-01 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US20090018142A9 (en) * 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
MX2009008347A (es) 2007-02-06 2009-10-19 Lixte Biotechnology Holdings I Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
CA2718472A1 (en) * 2007-08-03 2009-02-12 Lixte Biotechnology, Inc. Use of phosphatases to treat neuroblastomas and medulloblastomas
AU2008307541B2 (en) 2007-10-01 2015-02-12 Lixte Biotechnology, Inc. HDAC inhibitors
AU2009277086B2 (en) * 2008-08-01 2015-12-10 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
US8227473B2 (en) * 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
WO2010014141A1 (en) * 2008-08-01 2010-02-04 Lixte Biotechnology, Inc. Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase
WO2010147612A1 (en) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Methods of modulating cell regulation by inhibiting p53
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP2983661B1 (en) 2013-04-09 2024-05-29 Lixte Biotechnology, Inc. Formulations of oxabicycloheptanes and oxabicycloheptenes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
EP0045118B1 (en) * 1979-01-05 1984-04-04 National Research Development Corporation Intermediates for the synthesis of bicyclo (2,2,1) heptanes and bicyclo (2,2,1) hept-2z-enes
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA829068B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) * 1982-10-25 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) * 1983-01-12 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4525479A (en) * 1983-08-29 1985-06-25 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs useful as cardiovascular agents
US4526901A (en) * 1984-01-26 1985-07-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxamide prostaglandin analogs and their use in treating thrombolytic disease

Also Published As

Publication number Publication date
JPS6233181A (ja) 1987-02-13
GB2178430B (en) 1989-04-26
US4654355A (en) 1987-03-31
GB8618698D0 (en) 1986-09-10
FR2585703B1 (fr) 1988-08-19
IT8621342A0 (it) 1986-07-31
DE3625870A1 (de) 1987-02-05
IT1197033B (it) 1988-11-25
GB2178430A (en) 1987-02-11
CA1285569C (en) 1991-07-02
FR2585703A1 (fr) 1987-02-06

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