IT1191034B - Composto ad attivita' vasodilatatrice,antiaggregante e ipocolesterolemizzante,procedimento per la sua preparazione e composizione farmaceutiche relative - Google Patents

Composto ad attivita' vasodilatatrice,antiaggregante e ipocolesterolemizzante,procedimento per la sua preparazione e composizione farmaceutiche relative

Info

Publication number
IT1191034B
IT1191034B IT23770/82A IT2377082A IT1191034B IT 1191034 B IT1191034 B IT 1191034B IT 23770/82 A IT23770/82 A IT 23770/82A IT 2377082 A IT2377082 A IT 2377082A IT 1191034 B IT1191034 B IT 1191034B
Authority
IT
Italy
Prior art keywords
compound
colesterolemizing
hypo
vasodilator
aggregating
Prior art date
Application number
IT23770/82A
Other languages
English (en)
Italian (it)
Other versions
IT8223770A0 (it
IT8223770A1 (it
Inventor
Guido Vandoni
Original Assignee
Edmondo Pharma Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edmondo Pharma Srl filed Critical Edmondo Pharma Srl
Priority to IT23770/82A priority Critical patent/IT1191034B/it
Publication of IT8223770A0 publication Critical patent/IT8223770A0/it
Priority to DE8383109845T priority patent/DE3369136D1/de
Priority to AT83109845T priority patent/ATE24906T1/de
Priority to EP83109845A priority patent/EP0106251B1/en
Priority to US06/539,839 priority patent/US4542141A/en
Priority to ES526461A priority patent/ES8507538A1/es
Priority to JP58193326A priority patent/JPS5998082A/ja
Publication of IT8223770A1 publication Critical patent/IT8223770A1/it
Application granted granted Critical
Publication of IT1191034B publication Critical patent/IT1191034B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
    • C07D231/32—Oxygen atoms
    • C07D231/36—Oxygen atoms with hydrocarbon radicals, substituted by hetero atoms, attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IT23770/82A 1982-10-15 1982-10-15 Composto ad attivita' vasodilatatrice,antiaggregante e ipocolesterolemizzante,procedimento per la sua preparazione e composizione farmaceutiche relative IT1191034B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT23770/82A IT1191034B (it) 1982-10-15 1982-10-15 Composto ad attivita' vasodilatatrice,antiaggregante e ipocolesterolemizzante,procedimento per la sua preparazione e composizione farmaceutiche relative
DE8383109845T DE3369136D1 (en) 1982-10-15 1983-10-02 Pyrazolidinedione derivative having vasodilating, antiaggregating and hypocholesterolemic activities
AT83109845T ATE24906T1 (de) 1982-10-15 1983-10-02 Pyrazolidinedion-derivate mit gefaesserweiternder, antiaggregationer und hypocholesterolemischer wirkung.
EP83109845A EP0106251B1 (en) 1982-10-15 1983-10-02 Pyrazolidinedione derivative having vasodilating, antiaggregating and hypocholesterolemic activities
US06/539,839 US4542141A (en) 1982-10-15 1983-10-07 Compound having vasodilating, antiaggregating and hypocholesterolemic activities, process for the preparation thereof and pharmaceutical compositions therefrom
ES526461A ES8507538A1 (es) 1982-10-15 1983-10-14 Procedimiento para la preparacion del 1,2-difenil-4-(2-(fenilsulfinil)-etil)-4-(nicotinoiloximetil)-pirazolidin-3,5-diona
JP58193326A JPS5998082A (ja) 1982-10-15 1983-10-14 １，２―ジフェニル―４―〔２―（フェニルスルフィニル）エチル〕―４―（ニコチノイルオキシメチル）―ピラゾリジン―３，５―ジオン、その製造法およびそれを有効成分とする血栓治療剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23770/82A IT1191034B (it) 1982-10-15 1982-10-15 Composto ad attivita' vasodilatatrice,antiaggregante e ipocolesterolemizzante,procedimento per la sua preparazione e composizione farmaceutiche relative

Publications (3)

Publication Number Publication Date
IT8223770A0 IT8223770A0 (it) 1982-10-15
IT8223770A1 IT8223770A1 (it) 1984-04-15
IT1191034B true IT1191034B (it) 1988-02-24

Family

ID=11209829

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23770/82A IT1191034B (it) 1982-10-15 1982-10-15 Composto ad attivita' vasodilatatrice,antiaggregante e ipocolesterolemizzante,procedimento per la sua preparazione e composizione farmaceutiche relative

Country Status (7)

Country Link
US (1) US4542141A (enExample)
EP (1) EP0106251B1 (enExample)
JP (1) JPS5998082A (enExample)
AT (1) ATE24906T1 (enExample)
DE (1) DE3369136D1 (enExample)
ES (1) ES8507538A1 (enExample)
IT (1) IT1191034B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008257A (en) * 1982-05-18 1991-04-16 University Of Florida Brain-specific drug delivery
US5525727A (en) * 1982-05-18 1996-06-11 University Of Florida Brain-specific drug delivery
US5187158A (en) * 1982-05-18 1993-02-16 University Of Florida Brain-specific drug delivery
US4824850A (en) * 1982-05-18 1989-04-25 University Of Florida Brain-specific drug delivery
AU672578B2 (en) * 1991-03-19 1996-10-10 Novartis Ag Novel herbicidally, acaricidally and insecticidally active compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL89284C (enExample) * 1954-05-22
GB1084247A (enExample) * 1963-08-20
BR6685653D0 (pt) * 1965-12-23 1973-12-27 Spofa Vereinigte Pharma Werke Processo para a fabricacao de novas 4-substituidas 1,2-difenil-3,5-dioxopirazolidinas
ES347942A1 (es) * 1967-11-23 1969-03-01 Esteve Labor Dr Procedimiento para la obtencion de nuevos esteres de acidosp-halogenobenzoicos.
AT324331B (de) * 1972-09-27 1975-08-25 Hurka Wilhelm Verfahren zur herstellung neuer nicotin- und isonicotinsäureester substituierter pyrazolidine
FR2433020A1 (fr) * 1978-08-09 1980-03-07 Synthelabo Derives de pyrazolidine-dione et leur application en therapeutique

Also Published As

Publication number Publication date
ES526461A0 (es) 1985-10-01
EP0106251A1 (en) 1984-04-25
JPS5998082A (ja) 1984-06-06
ATE24906T1 (de) 1987-01-15
IT8223770A0 (it) 1982-10-15
JPS6346076B2 (enExample) 1988-09-13
ES8507538A1 (es) 1985-10-01
IT8223770A1 (it) 1984-04-15
EP0106251B1 (en) 1987-01-14
US4542141A (en) 1985-09-17
DE3369136D1 (en) 1987-02-19

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