ES8507538A1 - Procedimiento para la preparacion del 1,2-difenil-4-(2-(fenilsulfinil)-etil)-4-(nicotinoiloximetil)-pirazolidin-3,5-diona - Google Patents

Procedimiento para la preparacion del 1,2-difenil-4-(2-(fenilsulfinil)-etil)-4-(nicotinoiloximetil)-pirazolidin-3,5-diona

Info

Publication number
ES8507538A1
ES8507538A1 ES526461A ES526461A ES8507538A1 ES 8507538 A1 ES8507538 A1 ES 8507538A1 ES 526461 A ES526461 A ES 526461A ES 526461 A ES526461 A ES 526461A ES 8507538 A1 ES8507538 A1 ES 8507538A1
Authority
ES
Spain
Prior art keywords
antiaggregating
vasodilating
formula
solvent
pyrazolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526461A
Other languages
English (en)
Spanish (es)
Other versions
ES526461A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edmond Pharma SRL
Original Assignee
Edmond Pharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edmond Pharma SRL filed Critical Edmond Pharma SRL
Publication of ES526461A0 publication Critical patent/ES526461A0/es
Publication of ES8507538A1 publication Critical patent/ES8507538A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
    • C07D231/32—Oxygen atoms
    • C07D231/36—Oxygen atoms with hydrocarbon radicals, substituted by hetero atoms, attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ES526461A 1982-10-15 1983-10-14 Procedimiento para la preparacion del 1,2-difenil-4-(2-(fenilsulfinil)-etil)-4-(nicotinoiloximetil)-pirazolidin-3,5-diona Expired ES8507538A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23770/82A IT1191034B (it) 1982-10-15 1982-10-15 Composto ad attivita' vasodilatatrice,antiaggregante e ipocolesterolemizzante,procedimento per la sua preparazione e composizione farmaceutiche relative

Publications (2)

Publication Number Publication Date
ES526461A0 ES526461A0 (es) 1985-10-01
ES8507538A1 true ES8507538A1 (es) 1985-10-01

Family

ID=11209829

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526461A Expired ES8507538A1 (es) 1982-10-15 1983-10-14 Procedimiento para la preparacion del 1,2-difenil-4-(2-(fenilsulfinil)-etil)-4-(nicotinoiloximetil)-pirazolidin-3,5-diona

Country Status (7)

Country Link
US (1) US4542141A (enExample)
EP (1) EP0106251B1 (enExample)
JP (1) JPS5998082A (enExample)
AT (1) ATE24906T1 (enExample)
DE (1) DE3369136D1 (enExample)
ES (1) ES8507538A1 (enExample)
IT (1) IT1191034B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008257A (en) * 1982-05-18 1991-04-16 University Of Florida Brain-specific drug delivery
US4824850A (en) * 1982-05-18 1989-04-25 University Of Florida Brain-specific drug delivery
US5187158A (en) * 1982-05-18 1993-02-16 University Of Florida Brain-specific drug delivery
US5525727A (en) * 1982-05-18 1996-06-11 University Of Florida Brain-specific drug delivery
US5506193A (en) * 1991-03-19 1996-04-09 Ciba-Geigy Corporation Herbicidally, acaricidally and insecticidally active pyrazolidine compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE538332A (enExample) * 1954-05-22
GB1084247A (enExample) * 1963-08-20
BR6685653D0 (pt) * 1965-12-23 1973-12-27 Spofa Vereinigte Pharma Werke Processo para a fabricacao de novas 4-substituidas 1,2-difenil-3,5-dioxopirazolidinas
ES347942A1 (es) * 1967-11-23 1969-03-01 Esteve Labor Dr Procedimiento para la obtencion de nuevos esteres de acidosp-halogenobenzoicos.
AT324331B (de) * 1972-09-27 1975-08-25 Hurka Wilhelm Verfahren zur herstellung neuer nicotin- und isonicotinsäureester substituierter pyrazolidine
FR2433020A1 (fr) * 1978-08-09 1980-03-07 Synthelabo Derives de pyrazolidine-dione et leur application en therapeutique

Also Published As

Publication number Publication date
JPS5998082A (ja) 1984-06-06
DE3369136D1 (en) 1987-02-19
IT1191034B (it) 1988-02-24
ES526461A0 (es) 1985-10-01
JPS6346076B2 (enExample) 1988-09-13
IT8223770A1 (it) 1984-04-15
EP0106251B1 (en) 1987-01-14
ATE24906T1 (de) 1987-01-15
IT8223770A0 (it) 1982-10-15
EP0106251A1 (en) 1984-04-25
US4542141A (en) 1985-09-17

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506