IT1177013B - Analoghi interfenilene di prostaglandina 7-ossa-biciclo eptano sostituiti - Google Patents

Analoghi interfenilene di prostaglandina 7-ossa-biciclo eptano sostituiti

Info

Publication number
IT1177013B
IT1177013B IT23244/84A IT2324484A IT1177013B IT 1177013 B IT1177013 B IT 1177013B IT 23244/84 A IT23244/84 A IT 23244/84A IT 2324484 A IT2324484 A IT 2324484A IT 1177013 B IT1177013 B IT 1177013B
Authority
IT
Italy
Prior art keywords
intersthenylene
prostaglandin
analogs
bone
replaced
Prior art date
Application number
IT23244/84A
Other languages
English (en)
Other versions
IT8423244A0 (it
IT8423244A1 (it
Inventor
Das Jagabandhu
Martin F Haslanger
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8423244A0 publication Critical patent/IT8423244A0/it
Publication of IT8423244A1 publication Critical patent/IT8423244A1/it
Application granted granted Critical
Publication of IT1177013B publication Critical patent/IT1177013B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT23244/84A 1983-10-20 1984-10-19 Analoghi interfenilene di prostaglandina 7-ossa-biciclo eptano sostituiti IT1177013B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/543,681 US4522949A (en) 1983-10-20 1983-10-20 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular agents

Publications (3)

Publication Number Publication Date
IT8423244A0 IT8423244A0 (it) 1984-10-19
IT8423244A1 IT8423244A1 (it) 1986-04-19
IT1177013B true IT1177013B (it) 1987-08-26

Family

ID=24169118

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23244/84A IT1177013B (it) 1983-10-20 1984-10-19 Analoghi interfenilene di prostaglandina 7-ossa-biciclo eptano sostituiti

Country Status (6)

Country Link
US (1) US4522949A (it)
JP (1) JPS60105673A (it)
DE (1) DE3437903A1 (it)
FR (1) FR2553774A1 (it)
GB (1) GB2148293A (it)
IT (1) IT1177013B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515972A (en) * 1983-10-19 1985-05-07 E. R. Squibb & Sons, Inc. Intermediates and method for producing intermediates useful in the preparation of 7-oxabicycloheptane prostaglandin derivatives
US4658033A (en) * 1985-09-23 1987-04-14 Iowa State University Research Foundation, Inc. Synthesis of interphenylene prostaglandin analogs
US4695585A (en) * 1986-09-23 1987-09-22 E. R. Squibb & Sons, Inc. 7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of 5-lipoxygenase and cyclooxygenase
DE3638761A1 (de) * 1986-11-13 1988-05-26 Schering Ag Verbesserte ketoreduktion von carbacyclinzwischenprodukten
US4883811A (en) * 1988-11-17 1989-11-28 Misra Raj N 7-Oxabicycloheptane imino interphenylene substituted prostaglandin analogs useful in the treatment of thrombotic disease
US4883809A (en) * 1988-11-17 1989-11-28 Misra Raj N 7-Oxabicycloheptane imino interphenyleneoxy substituted prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5100889A (en) * 1989-04-03 1992-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5153327A (en) * 1988-12-23 1992-10-06 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US4977174A (en) * 1989-06-12 1990-12-11 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5126370A (en) * 1990-12-24 1992-06-30 E. R. Squibb & Sons, Inc. Anti-thrombotic heterocyclic amido prostaglandin analogs
US5135939A (en) * 1991-01-28 1992-08-04 E. R. Squibb & Sons, Inc. Heterocyclic ketone prostaglandin analogs
US5158967A (en) * 1991-06-12 1992-10-27 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5280034A (en) * 1991-08-23 1994-01-18 E. R. Squibb & Sons, Inc. Bis-heterocyclic prostaglandin analogs
US5827868A (en) * 1991-10-07 1998-10-27 E. R. Squibb & Sons, Inc. Prostaglandin analogs
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933900A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGEo oxa-phenylene compounds
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4368332A (en) * 1979-01-05 1983-01-11 National Research Development Corporation Prostaglandins
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA814307B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
US4463015A (en) * 1982-08-18 1984-07-31 E. R. Squibb & Sons, Inc. Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation

Also Published As

Publication number Publication date
US4522949A (en) 1985-06-11
FR2553774A1 (fr) 1985-04-26
DE3437903A1 (de) 1985-05-02
GB8426030D0 (en) 1984-11-21
IT8423244A0 (it) 1984-10-19
IT8423244A1 (it) 1986-04-19
JPS60105673A (ja) 1985-06-11
GB2148293A (en) 1985-05-30

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