IT1173456B - Esteri di diossolenilmetile di acido fosfinico quali inibitori di enzima convertitore di angiotensina - Google Patents

Esteri di diossolenilmetile di acido fosfinico quali inibitori di enzima convertitore di angiotensina

Info

Publication number
IT1173456B
IT1173456B IT20168/84A IT2016884A IT1173456B IT 1173456 B IT1173456 B IT 1173456B IT 20168/84 A IT20168/84 A IT 20168/84A IT 2016884 A IT2016884 A IT 2016884A IT 1173456 B IT1173456 B IT 1173456B
Authority
IT
Italy
Prior art keywords
dioxylenylmethyl
esters
phosphinic acid
enzyme inhibitors
inhibitors angiotensin
Prior art date
Application number
IT20168/84A
Other languages
English (en)
Italian (it)
Other versions
IT8420168A0 (it
Inventor
George C Rovnyak
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8420168A0 publication Critical patent/IT8420168A0/it
Application granted granted Critical
Publication of IT1173456B publication Critical patent/IT1173456B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT20168/84A 1983-03-24 1984-03-21 Esteri di diossolenilmetile di acido fosfinico quali inibitori di enzima convertitore di angiotensina IT1173456B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/478,598 US4555579A (en) 1983-03-24 1983-03-24 Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors

Publications (2)

Publication Number Publication Date
IT8420168A0 IT8420168A0 (it) 1984-03-21
IT1173456B true IT1173456B (it) 1987-06-24

Family

ID=23900577

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20168/84A IT1173456B (it) 1983-03-24 1984-03-21 Esteri di diossolenilmetile di acido fosfinico quali inibitori di enzima convertitore di angiotensina

Country Status (7)

Country Link
US (1) US4555579A (enEXAMPLES)
JP (1) JPS59181289A (enEXAMPLES)
CA (1) CA1243680A (enEXAMPLES)
DE (1) DE3410847A1 (enEXAMPLES)
FR (1) FR2543143B1 (enEXAMPLES)
GB (1) GB2137625B (enEXAMPLES)
IT (1) IT1173456B (enEXAMPLES)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK302883D0 (da) * 1983-06-30 1983-06-30 Hans Bundgaard Allopurinol prodrugs
US4634689A (en) * 1985-10-31 1987-01-06 Schering Corporation Phosphinylalkanoyl imino acids
JP3495376B2 (ja) * 1996-08-28 2004-02-09 ザ プロクター アンド ギャンブル カンパニー スピロ環メタロプロテアーゼ阻害剤
AU2006213663A1 (en) * 2005-02-11 2006-08-17 Aventis Pharmaceuticals Inc. Substituted propane phosphinic acid esters

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168267A (en) * 1978-10-23 1979-09-18 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl prolines
US4186268A (en) * 1979-01-29 1980-01-29 E. R. Squibb & Sons, Inc. Mercaptoacylpyrrolidine phosphonic acids and related compounds
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4379146A (en) * 1981-02-17 1983-04-05 Merck & Co., Inc. Substituted phosphonamides as antihypertensives
US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4448772A (en) * 1982-04-22 1984-05-15 E. R. Squibb & Sons, Inc. Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
US4427665A (en) * 1982-05-19 1984-01-24 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions

Also Published As

Publication number Publication date
GB2137625B (en) 1986-10-15
JPH047355B2 (enEXAMPLES) 1992-02-10
GB8406522D0 (en) 1984-04-18
US4555579A (en) 1985-11-26
IT8420168A0 (it) 1984-03-21
DE3410847A1 (de) 1984-09-27
GB2137625A (en) 1984-10-10
CA1243680A (en) 1988-10-25
JPS59181289A (ja) 1984-10-15
FR2543143B1 (fr) 1986-12-05
FR2543143A1 (fr) 1984-09-28

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