IT1104611B - Pleuromutilin solvates with a halogenated aliphatic hydrocarbon - useful for purifying crude pleuromutilin antibiotic - Google Patents
Pleuromutilin solvates with a halogenated aliphatic hydrocarbon - useful for purifying crude pleuromutilin antibioticInfo
- Publication number
- IT1104611B IT1104611B IT4840578A IT4840578A IT1104611B IT 1104611 B IT1104611 B IT 1104611B IT 4840578 A IT4840578 A IT 4840578A IT 4840578 A IT4840578 A IT 4840578A IT 1104611 B IT1104611 B IT 1104611B
- Authority
- IT
- Italy
- Prior art keywords
- pleuromutilin
- useful
- aliphatic hydrocarbon
- solvate
- halogenated aliphatic
- Prior art date
Links
- 239000012453 solvate Substances 0.000 title abstract 6
- ZRZNJUXESFHSIO-UHFFFAOYSA-N Pleuromutilin Natural products CC1C(O)C(C)(C=C)CC(OC(=O)CO)C2(C)C(C)CCC31C2C(=O)CC3 ZRZNJUXESFHSIO-UHFFFAOYSA-N 0.000 title abstract 4
- ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical compound C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 title abstract 4
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A solvate of pleuromutilin (I) with a halogenated aliphatic hydrocarbon (II) in the molar ratio of 1:1, is new. The solvate is useful for purifying (I), thus crude (I) can be converted into its solvate and which can be converted to pure (I) by e.g., heating. (I) is known antibiotic which can be converted into other pleuromutilin derivs. In an example, a solvate is prepd. by dissolving crude (I) in 1,1,1-trichloroethane, filtering off the insoluble impurities, cooling for 24 hrs. when the solvate crystallises out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4840578A IT1104611B (en) | 1978-03-13 | 1978-03-13 | Pleuromutilin solvates with a halogenated aliphatic hydrocarbon - useful for purifying crude pleuromutilin antibiotic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4840578A IT1104611B (en) | 1978-03-13 | 1978-03-13 | Pleuromutilin solvates with a halogenated aliphatic hydrocarbon - useful for purifying crude pleuromutilin antibiotic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7848405A0 IT7848405A0 (en) | 1978-03-13 |
| IT1104611B true IT1104611B (en) | 1985-10-21 |
Family
ID=11266352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT4840578A IT1104611B (en) | 1978-03-13 | 1978-03-13 | Pleuromutilin solvates with a halogenated aliphatic hydrocarbon - useful for purifying crude pleuromutilin antibiotic |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1104611B (en) |
-
1978
- 1978-03-13 IT IT4840578A patent/IT1104611B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT7848405A0 (en) | 1978-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970324 |