IT1052776B - Iattami w sostituiti - Google Patents
Iattami w sostituitiInfo
- Publication number
- IT1052776B IT1052776B IT6517523A IT1752365A IT1052776B IT 1052776 B IT1052776 B IT 1052776B IT 6517523 A IT6517523 A IT 6517523A IT 1752365 A IT1752365 A IT 1752365A IT 1052776 B IT1052776 B IT 1052776B
- Authority
- IT
- Italy
- Prior art keywords
- iattami
- replaced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB32037/64A GB1039113A (en) | 1964-08-06 | 1964-08-06 | New n-substituted lactams |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1052776B true IT1052776B (it) | 1981-07-20 |
Family
ID=10332139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT6517523A IT1052776B (it) | 1964-08-06 | 1965-08-04 | Iattami w sostituiti |
Country Status (15)
Country | Link |
---|---|
US (1) | US3459738A (it) |
AT (2) | AT261599B (it) |
BE (1) | BE667906A (it) |
CH (1) | CH436304A (it) |
CY (1) | CY727A (it) |
DE (1) | DE1620608C3 (it) |
DK (1) | DK121174B (it) |
ES (1) | ES316156A1 (it) |
FI (1) | FI45446C (it) |
FR (2) | FR1478349A (it) |
GB (1) | GB1039113A (it) |
IL (1) | IL24082A (it) |
IT (1) | IT1052776B (it) |
NL (1) | NL148313B (it) |
SE (1) | SE308526B (it) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
FR2059985A1 (en) * | 1969-08-29 | 1971-06-11 | Synthelabo | 4-benzyl piperidine 2,6-dione derivs |
US4081456A (en) * | 1973-02-28 | 1978-03-28 | Mobil Oil Corporation | Bis-lactam derivatives |
IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
AT360980B (de) * | 1976-01-14 | 1981-02-10 | Pliva Pharm & Chem Works | Verfahren zur herstellung von n-alkylamiden des 2-oxo-1-pyrrolidins |
US4069336A (en) * | 1976-02-25 | 1978-01-17 | Chemisches Laboratorium Fritz-Walter Lange Gmbh & Co Kg | (2-oxo-pyrrolidines)-acetic hydrazides |
GB1583871A (en) | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
GB1539817A (en) * | 1976-10-22 | 1979-02-07 | Ucb Sa | N-substituted lactams |
GB1582351A (en) * | 1977-02-10 | 1981-01-07 | Ucb Sa | Disubstituted ureas and thioureas |
DE2757680A1 (de) * | 1977-12-23 | 1979-06-28 | Troponwerke Gmbh & Co Kg | Neue 2-oxo-1-pyrrolidinessigsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
CA1115212A (en) | 1978-02-10 | 1981-12-29 | Emilio Kyburz | Pyrrolidine derivatives |
EP0005689B1 (fr) | 1978-05-08 | 1981-03-18 | U C B, S.A. | Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques |
DE2924011C2 (de) | 1979-06-13 | 1982-04-08 | A. Nattermann & Cie GmbH, 5000 Köln | Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten |
IT1141287B (it) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
EP0089900B1 (en) * | 1982-03-24 | 1985-12-27 | Prodes S.A. | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
US4525476A (en) * | 1983-05-26 | 1985-06-25 | Warner-Lambert Company | N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids and derivatives as cognition activators |
DE3326724A1 (de) * | 1983-07-25 | 1985-02-07 | Boehringer Ingelheim KG, 6507 Ingelheim | In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte |
DE3336024A1 (de) * | 1983-10-04 | 1985-04-18 | Boehringer Ingelheim KG, 6507 Ingelheim | 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel |
DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
FI83510C (fi) * | 1985-02-22 | 1991-07-25 | Ciba Geigy Ag | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara bi-2h- pyrroli(di)ndioner. |
PH23078A (en) * | 1986-01-30 | 1989-04-10 | Ciba Geigy Ag | Substituted pyrrolidinones |
IT1224168B (it) * | 1986-08-01 | 1990-09-26 | Finanziaria R F Spa Ora Finanz | Derivati del pirrolidin-2-one ad attivita' nootropa |
US4990513A (en) * | 1987-02-06 | 1991-02-05 | S O "Pharmachim" | Antihypoxic drug and method of its application |
WO1988009330A1 (en) * | 1987-05-20 | 1988-12-01 | Zambon Group S.P.A. | Isoxazoles with nootropic activity |
JPS6422883A (en) * | 1987-07-17 | 1989-01-25 | Sanwa Kagaku Kenkyusho Co | 1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient |
JP2660201B2 (ja) * | 1988-08-05 | 1997-10-08 | 塩野義製薬株式会社 | 新規ピロロ[1,4]ベンゾジアゼピン誘導体および老人性痴呆薬 |
NO179903C (no) * | 1992-06-19 | 1997-01-08 | Daiichi Seiyaku Co | Fremgangsmåte for fremstilling av et halogenacetamidderivat samt et pyrrolidinylacetamidderivat |
CN1041630C (zh) * | 1994-01-13 | 1999-01-13 | 北京大学 | 合成α-吡咯烷酮乙酰胺的方法 |
US5912189A (en) * | 1998-05-12 | 1999-06-15 | The Lubrizol Corporation | Compositions containing reaction product of a cyclic compound containing both a nitrogen atom and a carbonyl group, an aldehyde or ketone, and an etheramine |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
JPWO2002053153A1 (ja) * | 2000-12-28 | 2004-04-30 | 第一製薬株式会社 | 神経因性疼痛治療及び予防薬 |
AU2009219050B2 (en) | 2008-02-29 | 2014-04-24 | Biolab Sanus Farmaceutica Ltda. | Pharmaceutical composition comprising racetam and carnitine and process for its preparation |
DK2346500T3 (en) | 2008-10-16 | 2017-07-17 | Univ Johns Hopkins | Methods and compositions for improving cognitive function |
PL389364A1 (pl) | 2009-10-23 | 2011-04-26 | Uniwersytet Jagielloński | Nowe zastosowanie pochodnych 2-pirolidonu |
EA202092673A3 (ru) | 2010-02-09 | 2021-05-31 | Дзе Джонс Хопкинс Юниверсити | Способы и композиции для улучшения когнитивной функции |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
EP2968237A4 (en) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
US11213517B2 (en) | 2016-12-16 | 2022-01-04 | Idorsia Pharmaceuticals Ltd | Pharmaceutical combination comprising a T-type calcium channel blocker |
EA037205B1 (ru) * | 2019-05-20 | 2021-02-19 | Дмитрий Сергеевич Валуев | Способ получения 2-(2-оксопирролидин-1-ил)-n-фенилацетамида |
US20240132513A1 (en) | 2022-08-19 | 2024-04-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE592979A (it) * | 1959-07-14 | |||
US3185678A (en) * | 1961-08-04 | 1965-05-25 | Colgate Palmolive Co | Polymethyleniminoalkylamides |
US3250784A (en) * | 1963-12-23 | 1966-05-10 | Gen Aniline & Film Corp | Pyrrolidonyl-gamma-butyramide and process of preparing |
-
1964
- 1964-08-06 GB GB32037/64A patent/GB1039113A/en not_active Expired
-
1965
- 1965-08-02 NL NL656509994A patent/NL148313B/xx not_active IP Right Cessation
- 1965-08-03 IL IL24082A patent/IL24082A/xx unknown
- 1965-08-03 US US477004A patent/US3459738A/en not_active Expired - Lifetime
- 1965-08-04 FR FR27195A patent/FR1478349A/fr not_active Expired
- 1965-08-04 CH CH1096965A patent/CH436304A/fr unknown
- 1965-08-04 IT IT6517523A patent/IT1052776B/it active
- 1965-08-04 ES ES0316156A patent/ES316156A1/es not_active Expired
- 1965-08-04 DE DE1620608A patent/DE1620608C3/de not_active Expired
- 1965-08-05 DK DK403065AA patent/DK121174B/da unknown
- 1965-08-05 SE SE10249/65A patent/SE308526B/xx unknown
- 1965-08-05 FI FI651886A patent/FI45446C/fi active
- 1965-08-05 BE BE667906D patent/BE667906A/xx unknown
- 1965-08-06 AT AT1170666A patent/AT261599B/de active
- 1965-08-06 AT AT729765A patent/AT258260B/de active
- 1965-11-03 FR FR37061A patent/FR7119M/fr not_active Expired
-
1974
- 1974-03-01 CY CY72774A patent/CY727A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CY727A (en) | 1974-03-01 |
DE1620608C3 (de) | 1975-09-25 |
IL24082A (en) | 1969-02-27 |
ES316156A1 (es) | 1965-11-16 |
FR7119M (it) | 1969-07-21 |
CH436304A (fr) | 1967-05-31 |
DK121174B (da) | 1971-09-20 |
NL148313B (nl) | 1976-01-15 |
GB1039113A (en) | 1966-08-17 |
FR1478349A (fr) | 1967-04-28 |
BE667906A (it) | 1966-02-07 |
FI45446B (it) | 1972-02-29 |
DE1620608A1 (de) | 1970-04-30 |
FI45446C (fi) | 1972-06-12 |
DE1620608B2 (de) | 1975-01-30 |
NL6509994A (it) | 1966-02-07 |
AT258260B (de) | 1967-11-10 |
SE308526B (it) | 1969-02-17 |
AT261599B (de) | 1968-05-10 |
US3459738A (en) | 1969-08-05 |
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