IT1045480B - 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents - Google Patents

5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents

Info

Publication number
IT1045480B
IT1045480B IT2477774A IT2477774A IT1045480B IT 1045480 B IT1045480 B IT 1045480B IT 2477774 A IT2477774 A IT 2477774A IT 2477774 A IT2477774 A IT 2477774A IT 1045480 B IT1045480 B IT 1045480B
Authority
IT
Italy
Prior art keywords
nr10r11
alkyl
phenyl
derivs
pyrone
Prior art date
Application number
IT2477774A
Other languages
Italian (it)
Inventor
M Corno
P Sberze
G Doria
F Lauria
P Giraldi
M Tibolla
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Priority to IT2477774A priority Critical patent/IT1045480B/en
Priority to GB54453/74A priority patent/GB1479518A/en
Priority to SE7416231A priority patent/SE417427B/en
Priority to DK680474A priority patent/DK680474A/da
Priority to HU74EA00000142A priority patent/HU171874B/en
Priority to AU76878/74A priority patent/AU484454B2/en
Priority to NL7416873A priority patent/NL7416873A/en
Priority to CH1731074A priority patent/CH616934A5/en
Priority to SU742098258A priority patent/SU611590A3/en
Priority to FR7443125A priority patent/FR2255894B1/fr
Priority to CS749033A priority patent/CS202543B2/en
Priority to AT1034174A priority patent/AT345830B/en
Priority to FI3742/74A priority patent/FI67080C/en
Priority to DE19742461670 priority patent/DE2461670A1/en
Priority to CA216,961A priority patent/CA1061353A/en
Priority to JP753008A priority patent/JPS5634595B2/ja
Priority to NO744714A priority patent/NO144110C/en
Priority to IL46423A priority patent/IL46423A/en
Priority to US05/660,383 priority patent/US4065467A/en
Priority to US05/691,488 priority patent/US4115567A/en
Priority to AT547976A priority patent/AT345285B/en
Priority to US05/736,207 priority patent/US4083953A/en
Priority to US05/833,962 priority patent/US4148900A/en
Priority to CH388578A priority patent/CH616935A5/en
Application granted granted Critical
Publication of IT1045480B publication Critical patent/IT1045480B/en

Links

Abstract

(mostly new) of formula (I) (where n=0 or 1; n1=0 or 1; R is (a) cyano, carboxy or (b) COR9, where R9=-NHOH or NR10R11, where R10 and R11 are H or 1-6C alkyl or when R10 is H, R11 is or CH(R12)COOH, R12 being H or 1-6C alkyl or NR10R11 is N-pyrrolidinyl, piperidino or morpholino; (c) COOR13 where R13 is 1-12C alkyl or alkenyl opt. substd. by halogen, carboxy, hydroxy, OR14 or OCOR14, R14 is 1-6C alkyl, phenyl opt. substd., Nr10R11 or N-pyroalidyl, piperidino, morpholino or N-R13-piperazino; and R2 are H or Methyl; R3 and R4 are H or 1-6C alkyl; R5, R6, R7 and R8 are (a') H, halogen, hydroxy, NO2 or NR10R11; (b') (O)mR13, and m=0 or 1; (c') -OCOR15 and R15 is as R13 or NR10R11 or (d') SR13; or R7 and R8 when situated or adjacent C atoms are (m)ethylene dioxy, or propylenedioxy; X is phenyl or a 5 or 6-membered monoheterocyclic ring contg. double bond(s) and 1-2 N, O or S atoms or NO; W is CO, CS or may be in 6- or 7-position; with the exclusion of cpds. wherein X is Ph, W is CO, n and n1 are O; R5, R6, R7 are H, R is 6-COOH, and R8 is H or when in the 3' or 4' position of the phenyl gp. is OH, MeO, Cl, Br or I), are antiallergic agents esp. for oral administration and anti-ulcer agents.
IT2477774A 1973-12-27 1974-07-04 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents IT1045480B (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
IT2477774A IT1045480B (en) 1974-07-04 1974-07-04 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents
GB54453/74A GB1479518A (en) 1973-12-27 1974-12-17 5,6-benzo-ypsilon-pyrone derivatives
SE7416231A SE417427B (en) 1973-12-27 1974-12-23 SET TO MAKE 5,6-BENZO-GAMMA PYRONE DERIVATIVES
DK680474A DK680474A (en) 1973-12-27 1974-12-23
HU74EA00000142A HU171874B (en) 1973-12-27 1974-12-23 Process for preparing derivatives of 5,6-benzo-gamma-pyrone
NL7416873A NL7416873A (en) 1973-12-27 1974-12-24 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS AND WITH ANTI-ALLERGIC ACTION, THE PRODUCTS THEREFORE FORMED, AS WELL AS IRON FOR THE PREPARATION OF 5: 6-BENZO-RANGE DERIVATIVES.
CH1731074A CH616934A5 (en) 1973-12-27 1974-12-24 Process for the preparation of chromone derivatives
AU76878/74A AU484454B2 (en) 1974-07-04 1974-12-24 5:6-benzo-8-pyrone derivatives and process for their preparation
AT1034174A AT345830B (en) 1973-12-27 1974-12-27 PROCESS FOR THE PRODUCTION OF NEW 5: 6-BENZO-GAMMA-PYRON DERIVATIVES OR OF PHARMACEUTICAL SALT AND OPTICAL ISOMERS HIEVON
CS749033A CS202543B2 (en) 1973-12-27 1974-12-27 Method of producing novel derivatives of 5,6-benzo-gama-pyrone
SU742098258A SU611590A3 (en) 1973-12-27 1974-12-27 Method of preparing benzo-n-pyrone derivatives or salts thereof
FI3742/74A FI67080C (en) 1973-12-27 1974-12-27 FRAMEWORK FOR THE FRAMEWORK OF PHARMACEUTICALS ACTIVE 5: -BENZO-NY-PYRONDERIVAT
DE19742461670 DE2461670A1 (en) 1973-12-27 1974-12-27 5,6-BENZO-GAMMA-PYRONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE IN PHARMACEUTICAL PREPARATIONS
CA216,961A CA1061353A (en) 1973-12-27 1974-12-27 5:6-BENZO-.gamma.-PYRONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
JP753008A JPS5634595B2 (en) 1973-12-27 1974-12-27
NO744714A NO144110C (en) 1973-12-27 1974-12-27 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 5: 6-BENZO-4-PYRON DERIVATIVES
FR7443125A FR2255894B1 (en) 1973-12-27 1974-12-27
IL46423A IL46423A (en) 1973-12-27 1975-01-10 5:6-benzo-y-pyrone derivatives and process for their preparation
US05/660,383 US4065467A (en) 1973-12-27 1976-02-23 5:6-Benzo δ-pyrone derivatives and process for their preparation
US05/691,488 US4115567A (en) 1973-12-27 1976-06-01 6-Carboxy-2-(2'-pyrazinyl)-chromones and esters thereof
AT547976A AT345285B (en) 1974-07-04 1976-07-26 PROCESS FOR THE PREPARATION OF NEW 5: 6 BENZO-GAMMA-PYRON DERIVATIVES AND THEIR SALT AND ISOMERS
US05/736,207 US4083953A (en) 1973-12-27 1976-10-27 Pharmaceutical composition containing 5:6-benzo-alpha-pyrone derivatives and method of use thereof
US05/833,962 US4148900A (en) 1973-12-27 1977-09-16 5:6-Benzo-γ-pyrone derivatives and process for their preparation
CH388578A CH616935A5 (en) 1973-12-27 1978-03-13 Process for the preparation of chromone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2477774A IT1045480B (en) 1974-07-04 1974-07-04 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents

Publications (1)

Publication Number Publication Date
IT1045480B true IT1045480B (en) 1980-05-10

Family

ID=11214697

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2477774A IT1045480B (en) 1973-12-27 1974-07-04 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents

Country Status (1)

Country Link
IT (1) IT1045480B (en)

Similar Documents

Publication Publication Date Title
ES8604571A1 (en) Indole-3-carboxamide derivatives.
ES468077A1 (en) 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
BE802912A (en) DERIVATIVES OF (4 '- (3' '- INDOLYL) PIPERIDINO) ALCOYL-ARYLCETONES
ES387016A1 (en) Isoquinoline derivatives
AR031071A1 (en) DERIVATIVES OF DIHYDROBENZODIAZEPIN, A PROCEDURE FOR THEIR PREPARATION, THE USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
IT1045480B (en) 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents
SE7505237L (en) MORPHOLINE DERIVATIVES AND SET FOR THEIR PREPARATION.
ZA75417B (en) Novel tetracyclic piperidino derivatives
IE41916L (en) Amino-substituted tetracyclic compounds
ATE212634T1 (en) METALLOPROTEASE INHIBITORS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME
SE7701778L (en) 2,9-DIOXATRICYCLO / 4,3,1,0? 723? 717 / DEANS AND PROCEDURES FOR MANUFACTURE
CH550807A (en) DERIVATIVES OF 3,4-DIHYDRO-2,3- (LOWER ALKYL) -4OXO-1- (2H) QUINAZOLINECARBOXYLIC SUBSTITUTED IN 6 AND 7, USEFUL AS ANALGESIC AND TRANQUILIZING AGENTS.
ES394969A1 (en) 5-(2-amino-alkoxy-phenoxy-methyl)-3-alkyl-isoxazoles - useful as hypotensives and sedatives
FR2229413A1 (en) Para-4-quinolyl amino benzene sulphonamides - from a 4-chloro quinoline and a p-amino benzene sulphonamide, hypotensives etc.
BG97633A (en) Indenoindole compounds
ES394968A1 (en) 5-(2-amino-alkoxy-phenoxy-methyl)-3-alkyl-isoxazoles - useful as hypotensives and sedatives
FR2166101A1 (en) 1,4-di (morpholino,piperidino or pyrrolidino)-7-substd - -pyrido (3,4-d)-pyridazines - as diuretics
FR2263752A1 (en) 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants
FR2208659A1 (en) 13-Alkyl, alkoxy or allyl berberrubin derivatives - anticancer agents, prepd by demethylation of a 13-subst berberine salt
FR2247213A1 (en) 3-Aminocarbonylmethyl-5-methyl-1,2,4-oxadiazoles - with diuretic, sedative, antihistaminic analgesic and antiulcer activity
CH585224A5 (en) Central-inhibitory and neuroleptic fluoro- tricyclic cpds. - prepd. by reacting a 10-halo-fluoro-substd. dibenzothiepin with a substd piperazine
FR2239475A2 (en) Thiophosphoric - and thiophosphonic esters - by transesterification using a weak base as catalyst
NL7310390A (en) Thiophosphoric - and thiophosphonic esters - by transesterification using a weak base as catalyst
AU566911B2 (en) Triazalo pyridoquinazolines and their use in the treatment of allergies
BE803000R (en) Thiophosphoric - and thiophosphonic esters - by transesterification using a weak base as catalyst