IT1045480B - 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents - Google Patents
5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agentsInfo
- Publication number
- IT1045480B IT1045480B IT2477774A IT2477774A IT1045480B IT 1045480 B IT1045480 B IT 1045480B IT 2477774 A IT2477774 A IT 2477774A IT 2477774 A IT2477774 A IT 2477774A IT 1045480 B IT1045480 B IT 1045480B
- Authority
- IT
- Italy
- Prior art keywords
- nr10r11
- alkyl
- phenyl
- derivs
- pyrone
- Prior art date
Links
Abstract
(mostly new) of formula (I) (where n=0 or 1; n1=0 or 1; R is (a) cyano, carboxy or (b) COR9, where R9=-NHOH or NR10R11, where R10 and R11 are H or 1-6C alkyl or when R10 is H, R11 is or CH(R12)COOH, R12 being H or 1-6C alkyl or NR10R11 is N-pyrrolidinyl, piperidino or morpholino; (c) COOR13 where R13 is 1-12C alkyl or alkenyl opt. substd. by halogen, carboxy, hydroxy, OR14 or OCOR14, R14 is 1-6C alkyl, phenyl opt. substd., Nr10R11 or N-pyroalidyl, piperidino, morpholino or N-R13-piperazino; and R2 are H or Methyl; R3 and R4 are H or 1-6C alkyl; R5, R6, R7 and R8 are (a') H, halogen, hydroxy, NO2 or NR10R11; (b') (O)mR13, and m=0 or 1; (c') -OCOR15 and R15 is as R13 or NR10R11 or (d') SR13; or R7 and R8 when situated or adjacent C atoms are (m)ethylene dioxy, or propylenedioxy; X is phenyl or a 5 or 6-membered monoheterocyclic ring contg. double bond(s) and 1-2 N, O or S atoms or NO; W is CO, CS or may be in 6- or 7-position; with the exclusion of cpds. wherein X is Ph, W is CO, n and n1 are O; R5, R6, R7 are H, R is 6-COOH, and R8 is H or when in the 3' or 4' position of the phenyl gp. is OH, MeO, Cl, Br or I), are antiallergic agents esp. for oral administration and anti-ulcer agents.
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2477774A IT1045480B (en) | 1974-07-04 | 1974-07-04 | 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents |
GB54453/74A GB1479518A (en) | 1973-12-27 | 1974-12-17 | 5,6-benzo-ypsilon-pyrone derivatives |
SE7416231A SE417427B (en) | 1973-12-27 | 1974-12-23 | SET TO MAKE 5,6-BENZO-GAMMA PYRONE DERIVATIVES |
DK680474A DK680474A (en) | 1973-12-27 | 1974-12-23 | |
HU74EA00000142A HU171874B (en) | 1973-12-27 | 1974-12-23 | Process for preparing derivatives of 5,6-benzo-gamma-pyrone |
NL7416873A NL7416873A (en) | 1973-12-27 | 1974-12-24 | PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS AND WITH ANTI-ALLERGIC ACTION, THE PRODUCTS THEREFORE FORMED, AS WELL AS IRON FOR THE PREPARATION OF 5: 6-BENZO-RANGE DERIVATIVES. |
CH1731074A CH616934A5 (en) | 1973-12-27 | 1974-12-24 | Process for the preparation of chromone derivatives |
AU76878/74A AU484454B2 (en) | 1974-07-04 | 1974-12-24 | 5:6-benzo-8-pyrone derivatives and process for their preparation |
AT1034174A AT345830B (en) | 1973-12-27 | 1974-12-27 | PROCESS FOR THE PRODUCTION OF NEW 5: 6-BENZO-GAMMA-PYRON DERIVATIVES OR OF PHARMACEUTICAL SALT AND OPTICAL ISOMERS HIEVON |
CS749033A CS202543B2 (en) | 1973-12-27 | 1974-12-27 | Method of producing novel derivatives of 5,6-benzo-gama-pyrone |
SU742098258A SU611590A3 (en) | 1973-12-27 | 1974-12-27 | Method of preparing benzo-n-pyrone derivatives or salts thereof |
FI3742/74A FI67080C (en) | 1973-12-27 | 1974-12-27 | FRAMEWORK FOR THE FRAMEWORK OF PHARMACEUTICALS ACTIVE 5: -BENZO-NY-PYRONDERIVAT |
DE19742461670 DE2461670A1 (en) | 1973-12-27 | 1974-12-27 | 5,6-BENZO-GAMMA-PYRONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE IN PHARMACEUTICAL PREPARATIONS |
CA216,961A CA1061353A (en) | 1973-12-27 | 1974-12-27 | 5:6-BENZO-.gamma.-PYRONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION |
JP753008A JPS5634595B2 (en) | 1973-12-27 | 1974-12-27 | |
NO744714A NO144110C (en) | 1973-12-27 | 1974-12-27 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 5: 6-BENZO-4-PYRON DERIVATIVES |
FR7443125A FR2255894B1 (en) | 1973-12-27 | 1974-12-27 | |
IL46423A IL46423A (en) | 1973-12-27 | 1975-01-10 | 5:6-benzo-y-pyrone derivatives and process for their preparation |
US05/660,383 US4065467A (en) | 1973-12-27 | 1976-02-23 | 5:6-Benzo δ-pyrone derivatives and process for their preparation |
US05/691,488 US4115567A (en) | 1973-12-27 | 1976-06-01 | 6-Carboxy-2-(2'-pyrazinyl)-chromones and esters thereof |
AT547976A AT345285B (en) | 1974-07-04 | 1976-07-26 | PROCESS FOR THE PREPARATION OF NEW 5: 6 BENZO-GAMMA-PYRON DERIVATIVES AND THEIR SALT AND ISOMERS |
US05/736,207 US4083953A (en) | 1973-12-27 | 1976-10-27 | Pharmaceutical composition containing 5:6-benzo-alpha-pyrone derivatives and method of use thereof |
US05/833,962 US4148900A (en) | 1973-12-27 | 1977-09-16 | 5:6-Benzo-γ-pyrone derivatives and process for their preparation |
CH388578A CH616935A5 (en) | 1973-12-27 | 1978-03-13 | Process for the preparation of chromone derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2477774A IT1045480B (en) | 1974-07-04 | 1974-07-04 | 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1045480B true IT1045480B (en) | 1980-05-10 |
Family
ID=11214697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2477774A IT1045480B (en) | 1973-12-27 | 1974-07-04 | 5,6-Benzo-gamma-pyrone derivs. - as anti-allergic and anti-ulcer agents |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1045480B (en) |
-
1974
- 1974-07-04 IT IT2477774A patent/IT1045480B/en active
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