IS5391A - Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasa - Google Patents

Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasa

Info

Publication number
IS5391A
IS5391A IS5391A IS5391A IS5391A IS 5391 A IS5391 A IS 5391A IS 5391 A IS5391 A IS 5391A IS 5391 A IS5391 A IS 5391A IS 5391 A IS5391 A IS 5391A
Authority
IS
Iceland
Prior art keywords
elastase
neutralization
inhibit
pyrrolopyrrolone
derivatives
Prior art date
Application number
IS5391A
Other languages
English (en)
Inventor
Duke Edward Clarke Geoffrey
Dennis Dowle Michael
Finch Harry
Andrew Harrison Lee
George Adam Inglis Graham
Redpath Johnson Martin
John Fawcett Macdonald Simon
Shah Pritom
Andrew Smith Robin
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of IS5391A publication Critical patent/IS5391A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
IS5391A 1997-09-09 2000-02-29 Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasa IS5391A (is)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds
PCT/EP1998/005609 WO1999012933A2 (en) 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (1)

Publication Number Publication Date
IS5391A true IS5391A (is) 2000-02-29

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5391A IS5391A (is) 1997-09-09 2000-02-29 Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasa

Country Status (24)

Country Link
EP (1) EP1003748A2 (is)
JP (1) JP2001515904A (is)
KR (1) KR20010023766A (is)
CN (1) CN1278820A (is)
AP (1) AP2000001761A0 (is)
AR (1) AR017072A1 (is)
AU (1) AU9741298A (is)
BR (1) BR9812062A (is)
CA (1) CA2303176A1 (is)
CO (1) CO4970719A1 (is)
EA (1) EA200000204A1 (is)
EE (1) EE200000138A (is)
HU (1) HUP0004644A3 (is)
ID (1) ID24452A (is)
IL (1) IL134791A0 (is)
IS (1) IS5391A (is)
MA (1) MA26543A1 (is)
NO (1) NO20001198L (is)
NZ (1) NZ503130A (is)
PE (1) PE107899A1 (is)
PL (1) PL339176A1 (is)
SK (1) SK3192000A3 (is)
TR (1) TR200000907T2 (is)
WO (1) WO1999012933A2 (is)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
CN1960981A (zh) 2004-03-31 2007-05-09 詹森药业有限公司 作为组胺h3受体调节剂的非咪唑杂环化合物
DE102004024772A1 (de) 2004-05-17 2005-12-22 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
JP4853759B2 (ja) * 2004-05-27 2012-01-11 日本農薬株式会社 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
EP1819681B1 (en) 2004-11-23 2009-08-12 Warner-Lambert Company LLC 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
AU2007246889B2 (en) 2006-05-04 2011-03-10 Chiesi Farmaceutici S.P.A. Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
WO2009060206A1 (en) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
KR20220079527A (ko) 2019-09-17 2022-06-13 메레오 바이오파마 4 리미티드 이식편 거부반응, 폐쇄성 세기관지염 증후군 및 이식편 대 숙주병의 치료에 사용하기 위한 알베레스타트
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
AR006401A1 (es) * 1996-03-28 1999-08-25 Glaxo Group Ltd Compuestos de pirrolopirrolona, una composicion farmaceutica que los contiene, su uso en la fabricacion de un medicamento y en terapia, procesospara su preparación y compuestos intermediarios para dichos procesos.

Also Published As

Publication number Publication date
CN1278820A (zh) 2001-01-03
HUP0004644A2 (hu) 2001-09-28
BR9812062A (pt) 2000-09-26
WO1999012933A2 (en) 1999-03-18
JP2001515904A (ja) 2001-09-25
NO20001198D0 (no) 2000-03-08
AR017072A1 (es) 2001-08-22
EA200000204A1 (ru) 2000-10-30
AU9741298A (en) 1999-03-29
TR200000907T2 (tr) 2000-11-21
NZ503130A (en) 2001-08-31
EE200000138A (et) 2001-02-15
CO4970719A1 (es) 2000-11-07
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (en) 1999-05-27
HUP0004644A3 (en) 2002-01-28
IL134791A0 (en) 2001-04-30
AP2000001761A0 (en) 2000-03-31
MA26543A1 (fr) 2004-12-20
PE107899A1 (es) 1999-11-17
KR20010023766A (ko) 2001-03-26
PL339176A1 (en) 2000-12-04
CA2303176A1 (en) 1999-03-18
NO20001198L (no) 2000-05-08
EP1003748A2 (en) 2000-05-31
ID24452A (id) 2000-07-20

Similar Documents

Publication Publication Date Title
FI980732A0 (fi) Foerfarande foer koppling av dataoeverfoeringsstroemmar
FI980343A0 (fi) Foerfarande foer kontrollering av effekt
FI980783A0 (fi) Foerfarande foer utformning av en signaleringsfoerbindelse
IS4837A (is) Pýrrólópýrrólón afleiður sem latar fyrir hlutleysis elastasa
FI980465A0 (fi) Foerfarande foer installering av tjaenster
IS5391A (is) Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasa
FI980327A0 (fi) Foerfarande foer foermedling av telefonsamtal
FI970156A0 (fi) Foerfarande foer framstaellning av fiberplattor
FI980150A0 (fi) Foerfarande foer oeverfoering av bildinformation
FI980735A0 (fi) Foerfarande foer hantering av foerdroejning
IS5394A (is) Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasa
FI104103B1 (fi) Päällystyssauva
FI963067A0 (fi) Kuivausosalaite
FI970477A0 (fi) Foerfarande foer behandling av en oevantad nedkopplingsbegaeran
FR2782671B3 (fr) Livre
FI980044A0 (fi) Foerfarande foer behandling av en fiberbana
FI971222A0 (fi) Tillverkning av vaegmaerken
FI980095A0 (fi) Foerfarande foer byggande av fartyg
EE9900240A (et) Laagrisõlm
FI980443A0 (fi) Anordning foer maetning av en roerlig pappers- eller kartongbanas egenskaper
FI980839A0 (fi) Framstaellning av laktid
FI980710A0 (fi) Foerfarande foer smaeltning av stenmaterial foer mineralullsproduktion
DE29713908U1 (de) Wandungsbauelement
FI980146A0 (fi) Foerfarande foer roentgenavbildning av huvud- och halsomraodet
FI991149A (fi) Kuumavesiboileri