IS3612A7 - Novel úrefni 2-oxo-3,8-diazaspiro/4,5/decane, lyfjablöndur, sem innihalda þau og aðferðir til að framleiða þær - Google Patents
Novel úrefni 2-oxo-3,8-diazaspiro/4,5/decane, lyfjablöndur, sem innihalda þau og aðferðir til að framleiða þærInfo
- Publication number
- IS3612A7 IS3612A7 IS3612A IS3612A IS3612A7 IS 3612 A7 IS3612 A7 IS 3612A7 IS 3612 A IS3612 A IS 3612A IS 3612 A IS3612 A IS 3612A IS 3612 A7 IS3612 A7 IS 3612A7
- Authority
- IS
- Iceland
- Prior art keywords
- alkyl
- ethynyl
- fluorophenyl
- bis
- opt
- Prior art date
Links
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 title 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 title 1
- 239000001301 oxygen Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- RAPAKELQTSIJRM-UHFFFAOYSA-N 1-[4,4-bis(4-fluorophenyl)but-3-enyl]-4-ethynylpiperidin-4-ol;hydrochloride Chemical compound Cl.C1CC(O)(C#C)CCN1CCC=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 RAPAKELQTSIJRM-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- WYDMNGYRWISCLZ-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)prop-2-enyl]-4-ethynylpiperidin-4-ol;hydrochloride Chemical compound Cl.C1CC(O)(C#C)CCN1CC=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 WYDMNGYRWISCLZ-UHFFFAOYSA-N 0.000 abstract 1
- VLVWUSGOTSWICZ-UHFFFAOYSA-N [1-[4,4-bis(4-fluorophenyl)but-3-enyl]-4-ethynylpiperidin-4-yl] n-benzylcarbamate Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)=CCCN1CCC(C#C)(OC(=O)NCC=2C=CC=CC=2)CC1 VLVWUSGOTSWICZ-UHFFFAOYSA-N 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU894094A HU204276B (en) | 1989-08-10 | 1989-08-10 | Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS3612A7 true IS3612A7 (is) | 1991-02-11 |
Family
ID=10966866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS3612A IS3612A7 (is) | 1989-08-10 | 1990-08-09 | Novel úrefni 2-oxo-3,8-diazaspiro/4,5/decane, lyfjablöndur, sem innihalda þau og aðferðir til að framleiða þær |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5132303A (,) |
| EP (2) | EP0413516B1 (,) |
| JP (2) | JPH0381277A (,) |
| KR (2) | KR940002826B1 (,) |
| CN (1) | CN1025031C (,) |
| AT (2) | ATE104671T1 (,) |
| AU (2) | AU621771B2 (,) |
| CA (2) | CA2023018C (,) |
| DD (2) | DD299431A5 (,) |
| DE (2) | DE69014008T2 (,) |
| DK (1) | DK0413516T3 (,) |
| ES (2) | ES2052179T3 (,) |
| FI (1) | FI93456C (,) |
| HK (1) | HK118295A (,) |
| HU (2) | HU204276B (,) |
| IE (1) | IE902885A1 (,) |
| IL (2) | IL95324A (,) |
| IN (1) | IN170979B (,) |
| IS (1) | IS3612A7 (,) |
| MY (1) | MY107240A (,) |
| NO (1) | NO903511L (,) |
| NZ (2) | NZ234843A (,) |
| PL (2) | PL164662B1 (,) |
| SG (1) | SG59864G (,) |
| YU (2) | YU150489A (,) |
| ZA (3) | ZA906300B (,) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3752062T2 (de) * | 1986-12-17 | 1997-09-11 | Glaxo Group Ltd | Verwendung von heterozyklischen Derivaten zur Herstellung von Arzneimitteln |
| HU204529B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
| YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| EP0492020A1 (en) * | 1990-12-21 | 1992-07-01 | Merrell Dow Pharmaceuticals Inc. | Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders |
| GB9206989D0 (en) * | 1992-03-31 | 1992-05-13 | Glaxo Group Ltd | Chemical compounds |
| US5756743A (en) * | 1996-04-10 | 1998-05-26 | Hoechst Marion Roussel Inc. | Spiro cyclopent b!indole-piperidines! |
| US6100256A (en) * | 1996-12-02 | 2000-08-08 | Merck Sharp & Dohme Ltd. | Use of NK-1 receptors antagonists for treating schizophrenic disorders |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| US6974825B1 (en) | 1996-12-20 | 2005-12-13 | Astrazeneca Canada Inc. | Compounds with analgesic effect |
| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0101769D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101771D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101773D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101770D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| KR20030087248A (ko) * | 2002-05-08 | 2003-11-14 | (주)씨엔아이 | 온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치 |
| US8921555B2 (en) * | 2009-06-16 | 2014-12-30 | Merck Sharp & Dohme Corp. | Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones |
| GB201416352D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
| GB201416346D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL127065C (,) * | 1964-04-22 | |||
| CH601304A5 (,) * | 1974-02-12 | 1978-07-14 | Buskine Sa | |
| BE790675A (fr) * | 1971-10-29 | 1973-04-27 | Science Union & Cie | Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane |
| FR2615515B1 (fr) * | 1987-05-22 | 1989-06-30 | Adir | Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| HU204529B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
| HU204530B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
| YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
-
1989
- 1989-07-27 YU YU150489A patent/YU150489A/sh unknown
- 1989-08-10 HU HU894094A patent/HU204276B/hu not_active IP Right Cessation
- 1989-08-10 HU HU903233A patent/HU206677B/hu not_active IP Right Cessation
-
1990
- 1990-08-08 KR KR1019900012168A patent/KR940002826B1/ko not_active Expired - Fee Related
- 1990-08-08 KR KR1019900012169A patent/KR940000830B1/ko not_active Expired - Fee Related
- 1990-08-09 AT AT9090308783T patent/ATE104671T1/de not_active IP Right Cessation
- 1990-08-09 JP JP2209362A patent/JPH0381277A/ja active Pending
- 1990-08-09 ZA ZA906300A patent/ZA906300B/xx unknown
- 1990-08-09 SG SG1995903969A patent/SG59864G/en unknown
- 1990-08-09 DK DK90308783.1T patent/DK0413516T3/da active
- 1990-08-09 IS IS3612A patent/IS3612A7/is unknown
- 1990-08-09 EP EP90308783A patent/EP0413516B1/en not_active Expired - Lifetime
- 1990-08-09 YU YU154090A patent/YU154090A/sh unknown
- 1990-08-09 AU AU60803/90A patent/AU621771B2/en not_active Ceased
- 1990-08-09 IE IE288590A patent/IE902885A1/en unknown
- 1990-08-09 ZA ZA906299A patent/ZA906299B/xx unknown
- 1990-08-09 NO NO90903511A patent/NO903511L/no unknown
- 1990-08-09 ZA ZA906304A patent/ZA906304B/xx unknown
- 1990-08-09 DE DE69014008T patent/DE69014008T2/de not_active Expired - Fee Related
- 1990-08-09 NZ NZ234843A patent/NZ234843A/en unknown
- 1990-08-09 JP JP2209363A patent/JPH0383985A/ja active Pending
- 1990-08-09 EP EP90308779A patent/EP0412821B1/en not_active Expired - Lifetime
- 1990-08-09 AU AU60804/90A patent/AU621238B2/en not_active Ceased
- 1990-08-09 DD DD90343359A patent/DD299431A5/de not_active IP Right Cessation
- 1990-08-09 DD DD90343354A patent/DD299428A5/de not_active IP Right Cessation
- 1990-08-09 NZ NZ234846A patent/NZ234846A/en unknown
- 1990-08-09 IN IN687/CAL/90A patent/IN170979B/en unknown
- 1990-08-09 IL IL9532490A patent/IL95324A/en not_active IP Right Cessation
- 1990-08-09 IL IL9532590A patent/IL95325A/en not_active IP Right Cessation
- 1990-08-09 CA CA002023018A patent/CA2023018C/en not_active Expired - Fee Related
- 1990-08-09 ES ES90308783T patent/ES2052179T3/es not_active Expired - Lifetime
- 1990-08-09 ES ES90308779T patent/ES2063923T3/es not_active Expired - Lifetime
- 1990-08-09 AT AT90308779T patent/ATE113951T1/de not_active IP Right Cessation
- 1990-08-09 CA CA002023015A patent/CA2023015A1/en not_active Abandoned
- 1990-08-09 DE DE69008275T patent/DE69008275T2/de not_active Expired - Fee Related
- 1990-08-10 PL PL90291648A patent/PL164662B1/pl unknown
- 1990-08-10 MY MYPI90001343A patent/MY107240A/en unknown
- 1990-08-10 CN CN90106974A patent/CN1025031C/zh not_active Expired - Fee Related
- 1990-08-10 US US07/566,278 patent/US5132303A/en not_active Expired - Fee Related
- 1990-08-10 PL PL90286443A patent/PL163899B1/pl unknown
- 1990-08-10 US US07/566,279 patent/US5132309A/en not_active Expired - Fee Related
- 1990-08-10 FI FI903974A patent/FI93456C/fi not_active IP Right Cessation
-
1995
- 1995-07-20 HK HK118295A patent/HK118295A/en not_active IP Right Cessation
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