IN2015DN02875A - - Google Patents

Info

Publication number
IN2015DN02875A
IN2015DN02875A IN2875DEN2015A IN2015DN02875A IN 2015DN02875 A IN2015DN02875 A IN 2015DN02875A IN 2875DEN2015 A IN2875DEN2015 A IN 2875DEN2015A IN 2015DN02875 A IN2015DN02875 A IN 2015DN02875A
Authority
IN
India
Prior art keywords
enzalutamide
disclosure provides
hyperproliferative disorders
provides formulations
treating hyperproliferative
Prior art date
Application number
Inventor
Douglas Alan; Lorenz
Sanjay; Konagurthu
Randy J ; Wald
Jason A ; Everett
Sheila; Matz
Yuuki; Takaishi
Toshiro; Sakai
Ryousuke; Irie
Shinsuke; Oba
Hiroyasu; Toyota
Koji; Nishimura
Atsushi; Kanbayashi
Original Assignee
Medivation Prostate Therapeutics Inc
Bend Res
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49231627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2015DN02875(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medivation Prostate Therapeutics Inc, Bend Res, Astellas Pharma Inc filed Critical Medivation Prostate Therapeutics Inc
Publication of IN2015DN02875A publication Critical patent/IN2015DN02875A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
IN2875DEN2015 2012-09-11 2013-09-11 IN2015DN02875A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261699351P 2012-09-11 2012-09-11
PCT/US2013/059223 WO2014043208A1 (en) 2012-09-11 2013-09-11 Formulations of enzalutamide

Publications (1)

Publication Number Publication Date
IN2015DN02875A true IN2015DN02875A (en) 2015-09-11

Family

ID=49231627

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2875DEN2015 IN2015DN02875A (en) 2012-09-11 2013-09-11

Country Status (29)

Country Link
US (11) US20140179749A1 (en)
EP (6) EP4169908A1 (en)
JP (5) JP6404217B2 (en)
KR (1) KR102225416B1 (en)
CN (2) CN109897004A (en)
AU (2) AU2013315619B2 (en)
BR (1) BR112015005432B1 (en)
CA (1) CA2884795C (en)
CY (1) CY1124729T1 (en)
DK (1) DK3725778T3 (en)
EA (2) EA201991484A1 (en)
ES (1) ES2892029T3 (en)
HK (1) HK1212701A1 (en)
HR (1) HRP20211423T1 (en)
HU (1) HUE057701T2 (en)
IL (1) IL237604B (en)
IN (1) IN2015DN02875A (en)
LT (1) LT3725778T (en)
MX (3) MX363974B (en)
PH (1) PH12015500525A1 (en)
PL (1) PL3725778T3 (en)
PT (1) PT3725778T (en)
RS (1) RS62676B1 (en)
SI (1) SI3725778T1 (en)
SM (1) SMT202100550T1 (en)
TW (1) TWI673051B (en)
UA (1) UA117353C2 (en)
WO (1) WO2014043208A1 (en)
ZA (1) ZA201501847B (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3725778T3 (en) 2012-09-11 2021-12-20 Medivation Prostate Therapeutics Llc Formulations of enzalutamide
CA2885415C (en) 2012-09-26 2021-06-29 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
UA115805C2 (en) * 2013-04-17 2017-12-26 Сігнал Фармасьютікалз, Елелсі Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
CN112402360A (en) * 2014-02-05 2021-02-26 斯洛文尼亚莱柯制药股份有限公司 Solid pharmaceutical composition of androgen receptor antagonist
CN104356068A (en) * 2014-10-30 2015-02-18 杭州新博思生物医药有限公司 Novel Xtandi crystal form and preparation method thereof
MX384382B (en) * 2014-12-05 2025-03-14 Aragon Pharmaceuticals Inc ANTICANCER COMPOSITIONS.
EA201791222A1 (en) * 2014-12-05 2017-09-29 Арагон Фармасьютикалз, Инк. CONTRA-TRAY COMPOSITIONS
ES3019912T3 (en) 2014-12-05 2025-05-21 Aragon Pharmaceuticals Inc Anticancer compositions
WO2016130819A2 (en) * 2015-02-11 2016-08-18 Emergent Product Development Seattle Llc Compositions and methods for combination therapy with prostate-specific membrane antigen binding proteins
CN104546714A (en) * 2015-02-11 2015-04-29 江苏慧博生物科技有限公司 Enzalutamide micelle preparation and preparation method thereof
CN104857517B (en) * 2015-05-14 2018-04-27 南京海纳医药科技股份有限公司 A kind of miscellaneous Shandong amine soft capsule of grace and preparation method thereof
CA2987867C (en) 2015-06-09 2023-06-27 Capsugel Belgium Nv Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules
CN105030685B (en) * 2015-07-21 2018-02-27 福格森（武汉）生物科技股份有限公司 A kind of miscellaneous Shandong amine solid dispersions oral formulations of grace
WO2017027665A1 (en) 2015-08-12 2017-02-16 Medivation Prostate Therapeutics, Inc. Treatment of cancer using a combination of enzalutamide and a cyp3a4 inducer
WO2017035263A1 (en) * 2015-08-24 2017-03-02 Biocryst Pharmaceuticals, Inc. Compositions comprising a plasma kallikrein inhibitor
CA2999138C (en) 2015-09-21 2024-05-21 Aptevo Research And Development Llc Cd3 binding polypeptides
WO2017058869A1 (en) 2015-09-29 2017-04-06 Acorda Therapeutics, Inc. Sustained release compositions of 4-aminopyridine
CN107126419B (en) * 2016-02-26 2020-06-19 石药集团中诺药业（石家庄）有限公司 Obeticholic acid tablet and preparation method thereof
ES2900149T3 (en) 2016-07-21 2022-03-16 Hadasit Med Res Service Combinations comprising AR antagonists or inhibitors for use in the treatment of glioblastoma
WO2018037310A1 (en) 2016-08-20 2018-03-01 Ftf Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
PL3609464T3 (en) * 2017-04-13 2021-11-29 Jean Paul Remon Xanthohumol-based compositions
PL3616696T3 (en) * 2017-04-28 2025-05-05 Astellas Pharma Inc. Orally administrable enzalutamide-containing pharmaceutical composition
CN110996955A (en) 2017-06-22 2020-04-10 细胞基因公司 Treatment of hepatocellular carcinoma characterized by hepatitis B virus infection
WO2019016747A1 (en) * 2017-07-20 2019-01-24 Dr. Reddy's Laboratories Limited Amorphous solid dispersions of apalutamide and process for the preparation thereof
BR112020002705A2 (en) * 2017-08-08 2020-07-28 Dr. Reddys Laboratories Limited extruded enzalutamide compositions
BR112020007439A2 (en) 2017-10-16 2020-10-27 Aragon Pharmaceuticals, Inc. antiandrogens for the treatment of non-metastatic castration-resistant prostate cancer
US20200397756A1 (en) * 2018-02-09 2020-12-24 Kashiv Biosciences, Llc A stable pharmaceutical composition of poorly soluble nonsteroidal antiandrogens
JP7244536B2 (en) * 2018-04-06 2023-03-22 キャプシュゲル・ベルジウム・エヌ・ヴィ Spray-drying method for low-aspect-ratio particles of methyl methacrylate-methacrylic acid copolymer
CZ2018234A3 (en) 2018-05-21 2019-12-04 Zentiva Ks Increased solubility and bioavailability of enzalutamide
KR20210091191A (en) 2018-10-30 2021-07-21 펠로톤 테라퓨틱스, 인크. Solid Dispersions and Pharmaceutical Compositions Comprising Substituted Indanes and Methods of Making and Using the Same
EA202191372A1 (en) * 2018-12-14 2021-09-16 Фуджифилм Корпорэйшн TABLET AND METHOD FOR OBTAINING TABLETS
CN109432016B (en) * 2018-12-26 2021-03-02 广州中医药大学(广州中医药研究院) Enzalutamide ternary solid preparation and preparation method thereof
WO2020144650A1 (en) 2019-01-10 2020-07-16 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of prostate cancer
WO2020157699A1 (en) 2019-01-30 2020-08-06 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of metastatic castration-sensitive prostate cancer
AU2020215177A1 (en) 2019-01-30 2021-08-12 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
ES2992899T3 (en) 2019-05-16 2024-12-19 Leon Nanodrugs Gmbh Method for producing nanoparticles
EP3972569A1 (en) 2019-05-23 2022-03-30 Helm AG Nanoparticles comprising enzalutamide
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CA3143111A1 (en) 2019-06-27 2020-12-30 Synthon B.V. Process for preparation of enzalutamide
AU2020349524A1 (en) * 2019-09-18 2022-03-31 Bristol-Myers Squibb Company Dosage forms for Tyk2 inhibitors
JP7634525B2 (en) * 2019-09-23 2025-02-21 バイオノミクス リミテッド Therapeutic Formulations and Uses Thereof
EP4037659A1 (en) 2019-10-03 2022-08-10 Synthon BV Pharmaceutical composition comprising enzalutamide
EP4054572A1 (en) 2019-11-04 2022-09-14 Aragon Pharmaceuticals, Inc. Androgen receptor inhibitors for the treatment of non-metastatic castration-resistant prostate cancer in subjects with severe hepatic impairment
US20240016739A1 (en) * 2020-05-06 2024-01-18 Disruptive Pharma Ab Novel amorphous active pharmaceutical ingredients
AR118925A1 (en) * 2020-05-13 2021-11-10 Novocap S A CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION
WO2021240206A1 (en) 2020-05-24 2021-12-02 Lotus International Pte. Ltd. Enzalutamide formulation
WO2021245285A1 (en) 2020-06-05 2021-12-09 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
CN114053243B (en) * 2020-08-05 2024-11-12 齐鲁制药有限公司 A kind of Enzalutamide soft capsule and preparation method thereof
TW202228794A (en) 2020-09-04 2022-08-01 美商艾瑞岡醫藥公司 Methods for treating prostate cancer
LT4210700T (en) * 2020-09-09 2025-10-10 Formulations of a somatostatin modulator
WO2022061149A1 (en) * 2020-09-18 2022-03-24 Bristol-Myers Squibb Company Dosage forms for tyk2 inhibitors comprising swellable cores
CN112022812B (en) * 2020-11-03 2021-01-29 上海亚盛医药科技有限公司 Composition containing heterocyclic compounds, preparation method and application thereof
WO2022195407A1 (en) 2021-03-19 2022-09-22 Aragon Pharmaceuticals, Inc. Methods for treating prostate cancer
EP4340815A4 (en) 2021-07-07 2025-03-12 BDR Pharmaceuticals International Private Limited NEW ORAL LIQUID COMPOSITIONS OF ENZALUTAMIDE AND PROCESS FOR THEIR MANUFACTURE
CN115721612B (en) * 2021-08-26 2024-07-26 上海宣泰医药科技股份有限公司 Enza Lu An solid preparation granule and preparation method thereof
CN118251213A (en) * 2022-01-19 2024-06-25 四川科伦药物研究院有限公司 Solid dispersion, preparation method thereof and pharmaceutical composition containing same
CN114224832A (en) * 2022-02-11 2022-03-25 明度智云(浙江)科技有限公司 Enzalutamide injection and preparation method and application thereof
WO2023152611A1 (en) 2022-02-11 2023-08-17 Aragon Pharmaceuticals, Inc. Apalutamide and relugolix for the treatment of prostate cancer
WO2023209555A1 (en) 2022-04-26 2023-11-02 Aragon Pharmaceuticals, Inc. Approved drug products and methods for treating prostate cancer
WO2023244617A1 (en) * 2022-06-13 2023-12-21 Virginia Polytechnic Institute And State University Amphiphilic cellulose derivatives, methods of making, and uses thereof
TW202416960A (en) * 2022-06-17 2024-05-01 美商特朗奎斯治療股份有限公司 Formulations of 2-arylbenzimidazole compounds
CN115887395A (en) * 2022-11-18 2023-04-04 上海药坦药物研究开发有限公司 Enzalutamide solid dispersion preparation and preparation method and application thereof
EP4374853A1 (en) 2022-11-22 2024-05-29 Lotus Pharmaceutical Co., Ltd. Solid formulation of enzalutamide
WO2024153733A1 (en) 2023-01-18 2024-07-25 Helm Ag Crystalline nanoparticles comprising enzalutamide
WO2024191660A2 (en) * 2023-03-10 2024-09-19 Yale University Compositions and methods for treating steroid hormone-related diseases or disorders
TW202444354A (en) 2023-03-16 2024-11-16 瑞士商拜耳保健消費品股份有限公司 Androgen receptor antagonists for the treatment of patients with biochemical recurrence of hormone sensitive prostate cancer
WO2025052925A1 (en) * 2023-09-08 2025-03-13 沢井製薬株式会社 Enzalutamide solid dispersion and method for producing same, and enzalutamide-containing preparation and method for producing same
KR20250058470A (en) 2023-10-23 2025-04-30 케이원팜 주식회사 Novel Composition of Enzalutamide with Improved Stability and Dissolution Characteristics, and Process for Producing Thereof
EP4520322A1 (en) * 2023-12-06 2025-03-12 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical compositions containing enzalutamide
WO2025125565A1 (en) 2023-12-13 2025-06-19 Krka, D.D., Novo Mesto Tablet comprising enzalutamide
KR20250100928A (en) 2023-12-27 2025-07-04 케이원팜 주식회사 Novel Composition of Enzalutamide with Improved Bioavailability, and Process for Producing Thereof
CN118001243B (en) * 2024-01-31 2024-10-22 四川鲁徽制药有限责任公司 Enzalutamide orally disintegrating tablet and preparation method thereof

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656651A (en) * 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
TW486370B (en) 1996-12-25 2002-05-11 Yamanouchi Pharma Co Ltd Rapidly disintegrable pharmaceutical composition
DK0901786T3 (en) * 1997-08-11 2007-10-08 Pfizer Prod Inc Solid pharmaceutical dispersions with increased bioavailability
EP1741424B1 (en) 1997-08-11 2018-10-03 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailabilty
IN191496B (en) 1999-07-30 2003-12-06 Ranbaxy Lab Ltd
AR027656A1 (en) 2000-03-16 2003-04-09 Pfizer Prod Inc PHARMACEUTICAL COMPOSITIONS OF INHIBITORS OF GLUCOGENO-FOSFORILASA
CZ20032225A3 (en) 2001-02-27 2003-11-12 Astrazeneca Ab Pharmaceutical formulation
SE0103424D0 (en) 2001-10-15 2001-10-15 Astrazeneca Ab Pharmaceutical formulation
GB2383042A (en) 2001-10-18 2003-06-18 Cipla Ltd Amorphous alendronate sodium
SE0103839D0 (en) 2001-11-16 2001-11-16 Astrazeneca Ab Pharmaceutical formulation & product
WO2003063821A2 (en) 2002-02-01 2003-08-07 Pfizer Products Inc. Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles
AU2003229912A1 (en) 2002-04-18 2003-11-03 Avecia Limited Prepation of a conjugated molecule and materials for use therein
JP4249950B2 (en) 2002-06-28 2009-04-08 富士フイルム株式会社 Paper tube cutting device and paper tube cutting method
AU2003209667A1 (en) * 2003-02-21 2004-09-09 Hetero Drugs Limited Bicalutamide polymorphs
EP1730516A1 (en) 2004-03-30 2006-12-13 Pfizer Products Incorporated Method and device for evaluation of pharmaceutical compositions
PL2444085T3 (en) * 2005-05-13 2015-07-31 Univ California Diarylhydantoin compounds as androgen receptor antagonists for the treatment of cancer
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
CA2608952A1 (en) * 2005-05-19 2006-11-23 Dwayne Thomas Friesen Pharmaceutical compostions comprising an amorphous form of a vegf-r inhibitor
BRPI0614455A2 (en) 2005-07-28 2011-03-29 Isp Investments Inc amorphous efavirenz and the production of this
HUE042037T2 (en) 2006-03-27 2019-06-28 Univ California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
WO2008080037A2 (en) 2006-12-21 2008-07-03 Isp Investments Inc. Carotenoids of enhanced bioavailability
EP2134327A1 (en) 2007-03-13 2009-12-23 Sandoz AG Pharmaceutical compositions of poorly soluble drugs
AU2009224418B2 (en) 2008-03-11 2014-12-11 Aska Pharmaceutical Co., Ltd. Solid dispersion, pharmaceutical compositions containing the same, and processes for the production of both
ES2552386T3 (en) 2009-04-03 2015-11-27 F. Hoffmann-La Roche Ag Propane-1-sulfonic acid {3- [5- (4-chloro-phenyl) -1H-pyrrole [2,3-b] pyridin-3-carbonyl] -2,4-difluoro-phenyl} -amide compositions and uses thereof
US20100297194A1 (en) * 2009-04-30 2010-11-25 Nathaniel Catron Formulation for oral administration of apoptosis promoter
PL3329775T3 (en) * 2010-02-24 2021-11-08 Medivation Prostate Therapeutics Llc Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
US20110312973A1 (en) * 2010-03-10 2011-12-22 Bernd Liepold Solid compositions
UY34632A (en) * 2012-02-24 2013-05-31 Novartis Ag OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME
CA3114726A1 (en) 2012-06-07 2013-12-12 Aragon Pharmaceuticals, Inc. Crystalline forms of an androgen receptor modulator
EP2883271B1 (en) * 2012-08-10 2020-07-22 Keyssa, Inc. Dielectric coupling systems for ehf communications
PL3725778T3 (en) 2012-09-11 2021-12-20 Medivation Prostate Therapeutics Llc Formulations of enzalutamide
WO2014042945A1 (en) 2012-09-11 2014-03-20 Bend Research, Inc. Methods for making pharmaceutical solid dosage forms of spray-dried dispersions
CA2884640A1 (en) 2012-09-11 2014-03-20 Dr. Reddy's Laboratories Limited Enzalutamide polymorphic forms and its preparation
WO2014167428A2 (en) 2013-04-10 2014-10-16 Shilpa Medicare Limited Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide
PL3616696T3 (en) 2017-04-28 2025-05-05 Astellas Pharma Inc. Orally administrable enzalutamide-containing pharmaceutical composition
US20190208236A1 (en) 2018-01-02 2019-07-04 Source Digital, Inc. Coordinates as ancillary data
EP4037659A1 (en) 2019-10-03 2022-08-10 Synthon BV Pharmaceutical composition comprising enzalutamide

Also Published As

Publication number Publication date
US20140179749A1 (en) 2014-06-26
IL237604A0 (en) 2015-04-30
AU2018200316A1 (en) 2018-02-08
HUE057701T2 (en) 2022-05-28
WO2014043208A1 (en) 2014-03-20
IL237604B (en) 2021-07-29
EP2895463A1 (en) 2015-07-22
JP2021178871A (en) 2021-11-18
RS62676B1 (en) 2021-12-31
DK3725778T3 (en) 2021-09-20
EA033374B9 (en) 2019-12-18
AU2013315619B2 (en) 2018-02-08
HK1212701A1 (en) 2016-06-17
PT3725778T (en) 2021-09-22
CN105358535A (en) 2016-02-24
EA033374B1 (en) 2019-10-31
CY1124729T1 (en) 2022-07-22
MX2021000007A (en) 2021-03-09
PL3725778T3 (en) 2021-12-20
KR102225416B1 (en) 2021-03-09
JP6404217B2 (en) 2018-10-10
ES2892029T3 (en) 2022-02-01
EP3725778B1 (en) 2021-08-18
US20140378517A1 (en) 2014-12-25
BR112015005432A2 (en) 2017-09-05
UA117353C2 (en) 2018-07-25
JP6932746B2 (en) 2021-09-08
EP3725778A1 (en) 2020-10-21
MX2015003140A (en) 2015-12-16
AU2013315619A1 (en) 2015-04-30
EP4450130A2 (en) 2024-10-23
US20250049721A1 (en) 2025-02-13
JP2018087206A (en) 2018-06-07
TWI673051B (en) 2019-10-01
EP3971167A1 (en) 2022-03-23
MX2019003984A (en) 2019-08-12
US20190209476A1 (en) 2019-07-11
EA201500314A1 (en) 2015-12-30
EA201991484A1 (en) 2019-11-29
US20170027910A1 (en) 2017-02-02
US20230122911A1 (en) 2023-04-20
EP4169908A1 (en) 2023-04-26
EP4324527A3 (en) 2024-04-24
US20250090465A1 (en) 2025-03-20
CA2884795C (en) 2023-10-17
US20200060976A1 (en) 2020-02-27
EP4450130A3 (en) 2025-01-08
HRP20211423T1 (en) 2022-01-21
JP2015527411A (en) 2015-09-17
BR112015005432B1 (en) 2023-04-18
JP2019194262A (en) 2019-11-07
US20230210778A1 (en) 2023-07-06
CA2884795A1 (en) 2014-03-20
US20170224624A1 (en) 2017-08-10
US11839689B2 (en) 2023-12-12
JP2016204392A (en) 2016-12-08
CN109897004A (en) 2019-06-18
US20140100256A1 (en) 2014-04-10
CN105358535B (en) 2019-01-04
SMT202100550T1 (en) 2022-01-10
KR20150082203A (en) 2015-07-15
LT3725778T (en) 2021-12-27
ZA201501847B (en) 2016-01-27
MX363974B (en) 2019-04-10
PH12015500525A1 (en) 2015-05-04
TW201427659A (en) 2014-07-16
EP4324527A2 (en) 2024-02-21
SI3725778T1 (en) 2022-02-28

Similar Documents

Publication Publication Date Title
PH12015500525A1 (en) Formulations of enzalutamide
IN2015DN00127A (en)
IL239355A0 (en) Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
PH12014502132A1 (en) Anti-lgr5 antibodies and immunoconjugates
IL239453B (en) Compositions and methods for treatment of cancer using bacteria
MY168032A (en) Warm-Cool Beauty Treatment Device
PH12014501605A1 (en) Anti-lrp5 antibodies and methods of use
IN2014DN11201A (en)
IL238177A0 (en) Methods and compositions for the treatment of cancer
ZA201408056B (en) Compositions and methods for the treatment of mucositis
ZA201408055B (en) Compositions and methods for the treatment of local pain
EP2897689A4 (en) Systems, compositions and methods for the treatment of alopecia
IL239374A0 (en) Compositions and methods for the treatment of brain cancers
MX2016008150A (en) Berberine formulations and uses thereof.
GEP201706764B (en) Quinazolin-thf-amines as pde1 inhibitors
GEP20186920B (en) Halogenated quinazolinthf-amines as pde1 inhibitors
ZA201408060B (en) Compositions and methods for the treatment of neurological disorders
EA201590615A1 (en) STIMULATING LACTATION COMPOSITIONS BASED ON PHOSPHATIDIDILSERIN
ZA201408061B (en) Compositions and methods for the treatment of neurological disorders
ZA201408058B (en) Compositions and methods for the treatment of epilepsy
MY168958A (en) Intermediates and processes for preparing compounds
AU2013902004A0 (en) Compositions for Therapy and Methods of Treatment
UA80618U (en) Use of n-steroylethanolamine as radiomodifier
AU2012902296A0 (en) Compositions for Therapy and Methods of Treatment
UA80747U (en) Use of octenisept for sanitization of articular cavity in treatment of metaepiphyseal osteomyelitis