AR118925A1 - CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION - Google Patents

CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION

Info

Publication number
AR118925A1
AR118925A1 ARP200101366A ARP200101366A AR118925A1 AR 118925 A1 AR118925 A1 AR 118925A1 AR P200101366 A ARP200101366 A AR P200101366A AR P200101366 A ARP200101366 A AR P200101366A AR 118925 A1 AR118925 A1 AR 118925A1
Authority
AR
Argentina
Prior art keywords
solution
concentrated liquid
preparing
procedure
antiandrogens
Prior art date
Application number
ARP200101366A
Other languages
Spanish (es)
Inventor
Andres Gold
Original Assignee
Novocap S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocap S A filed Critical Novocap S A
Priority to ARP200101366A priority Critical patent/AR118925A1/en
Priority to PCT/IB2020/055416 priority patent/WO2021229278A1/en
Publication of AR118925A1 publication Critical patent/AR118925A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin

Abstract

Solución líquida concentrada de antiandrógenos no esteroideos, conteniendo entre 80 mg y 140 mg de enzalutamida o apalutamida por cada gramo de solución, que comprende copovidona y polioxilgliceridos de caprilocaproilo como excipientes. Se provee además un procedimiento de obtención, en donde se prepara una mezcla de copovidona y polioxilgliceridos de caprilocaproilo y luego se adiciona a la mezcla un antriandrógeno no esteroideo, manteniendo la agitación a una temperatura de 100ºC o más hasta formar una solución.Concentrated liquid solution of nonsteroidal antiandrogens, containing between 80 mg and 140 mg of enzalutamide or apalutamide per gram of solution, comprising copovidone and caprylocaproyl polyoxylglycerides as excipients. A process for obtaining it is also provided, in which a mixture of copovidone and caprylocaproyl polyoxylglycerides is prepared and then a non-steroidal antiandrogen is added to the mixture, maintaining stirring at a temperature of 100ºC or more until a solution is formed.

ARP200101366A 2020-05-13 2020-05-13 CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION AR118925A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ARP200101366A AR118925A1 (en) 2020-05-13 2020-05-13 CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION
PCT/IB2020/055416 WO2021229278A1 (en) 2020-05-13 2020-06-09 Concentrated liquid non-steroidal antiandrogen solution and method for preparing the solution

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP200101366A AR118925A1 (en) 2020-05-13 2020-05-13 CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION

Publications (1)

Publication Number Publication Date
AR118925A1 true AR118925A1 (en) 2021-11-10

Family

ID=78525123

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200101366A AR118925A1 (en) 2020-05-13 2020-05-13 CONCENTRATED LIQUID SOLUTION OF NON-STEROID ANTIANDROGENS AND PROCEDURE FOR PREPARING THE SOLUTION

Country Status (2)

Country Link
AR (1) AR118925A1 (en)
WO (1) WO2021229278A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201991484A1 (en) * 2012-09-11 2019-11-29 MEDICINAL FORMS OF ENZALUTAMIDE
EP3500310A1 (en) * 2016-08-20 2019-06-26 FTF Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
MX2020000213A (en) * 2017-07-04 2020-08-17 Bdr Pharmaceuticals International Private Ltd Novel composition of enzalutamide oral dosage form and method of manufacturing thereof.
US20200397756A1 (en) * 2018-02-09 2020-12-24 Kashiv Biosciences, Llc A stable pharmaceutical composition of poorly soluble nonsteroidal antiandrogens

Also Published As

Publication number Publication date
WO2021229278A1 (en) 2021-11-18

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