US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
US3673612A
(en)
|
1970-08-28 |
1972-07-04 |
Massachusetts Inst Technology |
Non-thrombogenic materials and methods for their preparation
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
US4668777A
(en)
|
1981-03-27 |
1987-05-26 |
University Patents, Inc. |
Phosphoramidite nucleoside compounds
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
US4476301A
(en)
|
1982-04-29 |
1984-10-09 |
Centre National De La Recherche Scientifique |
Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
|
US4517338A
(en)
|
1983-06-20 |
1985-05-14 |
Chiron Corporation |
Multiple reactor system and method for polynucleotide synthesis
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
USRE34069E
(en)
|
1983-08-18 |
1992-09-15 |
Biosyntech Gmbh |
Process for the preparation of oligonucleotides
|
US4672110A
(en)
|
1983-11-29 |
1987-06-09 |
Northwestern University |
Method of deprotecting polynucleotide trimethylethyl phosphotriesters
|
WO1988009301A1
(en)
|
1987-05-19 |
1988-12-01 |
Spirac Engineering Ab |
A transportation device
|
US5550111A
(en)
|
1984-07-11 |
1996-08-27 |
Temple University-Of The Commonwealth System Of Higher Education |
Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
US5235033A
(en)
|
1985-03-15 |
1993-08-10 |
Anti-Gene Development Group |
Alpha-morpholino ribonucleoside derivatives and polymers thereof
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
US5405938A
(en)
|
1989-12-20 |
1995-04-11 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
US4888278A
(en)
|
1985-10-22 |
1989-12-19 |
University Of Massachusetts Medical Center |
In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
|
US4659774A
(en)
|
1985-11-01 |
1987-04-21 |
American Hoechst Corporation |
Support for solid-phase oligonucleotide synthesis
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
US5153319A
(en)
|
1986-03-31 |
1992-10-06 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US5319079A
(en)
|
1986-05-15 |
1994-06-07 |
Beckman Instruments, Inc. |
Process for terminal substituting of a polynucleotide
|
US4806463A
(en)
|
1986-05-23 |
1989-02-21 |
Worcester Foundation For Experimental Biology |
Inhibition of HTLV-III by exogenous oligonucleotides
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
US5276019A
(en)
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
US4924624A
(en)
|
1987-10-22 |
1990-05-15 |
Temple University-Of The Commonwealth System Of Higher Education |
2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
|
US5188897A
(en)
|
1987-10-22 |
1993-02-23 |
Temple University Of The Commonwealth System Of Higher Education |
Encapsulated 2',5'-phosphorothioate oligoadenylates
|
WO1989009221A1
(en)
|
1988-03-25 |
1989-10-05 |
University Of Virginia Alumni Patents Foundation |
Oligonucleotide n-alkylphosphoramidates
|
US5278302A
(en)
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
US5218103A
(en)
|
1988-05-26 |
1993-06-08 |
University Patents, Inc. |
Nucleoside thiophosphoramidites
|
US5216141A
(en)
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
US4958013A
(en)
*
|
1989-06-06 |
1990-09-18 |
Northwestern University |
Cholesteryl modified oligonucleotides
|
US5399676A
(en)
|
1989-10-23 |
1995-03-21 |
Gilead Sciences |
Oligonucleotides with inverted polarity
|
US5264562A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences, Inc. |
Oligonucleotide analogs with novel linkages
|
US5264564A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences |
Oligonucleotide analogs with novel linkages
|
US5177198A
(en)
|
1989-11-30 |
1993-01-05 |
University Of N.C. At Chapel Hill |
Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
|
US5804604A
(en)
|
1989-12-21 |
1998-09-08 |
Biogen, Inc. |
Tat-derived transport polypeptides and fusion proteins
|
US6316003B1
(en)
|
1989-12-21 |
2001-11-13 |
Whitehead Institute For Biomedical Research |
Tat-derived transport polypeptides
|
US5670617A
(en)
|
1989-12-21 |
1997-09-23 |
Biogen Inc |
Nucleic acid conjugates of tat-derived transport polypeptides
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
US5321131A
(en)
|
1990-03-08 |
1994-06-14 |
Hybridon, Inc. |
Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
|
WO1991014696A1
(en)
|
1990-03-29 |
1991-10-03 |
Gilead Sciences, Inc. |
Oligonucleotide-transport agent disulfide conjugates
|
US5470967A
(en)
|
1990-04-10 |
1995-11-28 |
The Dupont Merck Pharmaceutical Company |
Oligonucleotide analogs with sulfamate linkages
|
US6610841B1
(en)
|
1997-12-18 |
2003-08-26 |
Gilead Sciences, Inc. |
Nucleotide-based prodrugs
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
ATE131827T1
(de)
|
1990-08-03 |
1996-01-15 |
Sterling Winthrop Inc |
Verbindungen und verfahren zur unterdrückung der genexpression
|
US5177196A
(en)
|
1990-08-16 |
1993-01-05 |
Microprobe Corporation |
Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
|
US5214134A
(en)
|
1990-09-12 |
1993-05-25 |
Sterling Winthrop Inc. |
Process of linking nucleosides with a siloxane bridge
|
US5561225A
(en)
|
1990-09-19 |
1996-10-01 |
Southern Research Institute |
Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
|
CA2092002A1
(en)
|
1990-09-20 |
1992-03-21 |
Mark Matteucci |
Modified internucleoside linkages
|
US5733523A
(en)
|
1990-12-10 |
1998-03-31 |
Akzo Nobel N.V. |
Targeted delivery of a therapeutic entity using complementary oligonucleotides
|
US5571799A
(en)
|
1991-08-12 |
1996-11-05 |
Basco, Ltd. |
(2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
|
NZ244306A
(en)
|
1991-09-30 |
1995-07-26 |
Boehringer Ingelheim Int |
Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
|
TW323284B
(hu)
|
1992-03-23 |
1997-12-21 |
Novartis Ag |
|
US5633360A
(en)
|
1992-04-14 |
1997-05-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs capable of passive cell membrane permeation
|
FR2692265B1
(fr)
*
|
1992-05-25 |
1996-11-08 |
Centre Nat Rech Scient |
Composes biologiquement actifs de type phosphotriesters.
|
US5434257A
(en)
|
1992-06-01 |
1995-07-18 |
Gilead Sciences, Inc. |
Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
|
US5489525A
(en)
|
1992-10-08 |
1996-02-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Monoclonal antibodies to prostate cells
|
US5476925A
(en)
|
1993-02-01 |
1995-12-19 |
Northwestern University |
Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
|
GB9304618D0
(en)
|
1993-03-06 |
1993-04-21 |
Ciba Geigy Ag |
Chemical compounds
|
WO1994022891A1
(en)
|
1993-03-31 |
1994-10-13 |
Sterling Winthrop Inc. |
Oligonucleotides with amide linkages replacing phosphodiester linkages
|
US5955591A
(en)
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
JPH0799976A
(ja)
*
|
1993-09-30 |
1995-04-18 |
Takeda Chem Ind Ltd |
修飾オリゴヌクレオチド
|
US5625050A
(en)
|
1994-03-31 |
1997-04-29 |
Amgen Inc. |
Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
|
US5622867A
(en)
|
1994-10-19 |
1997-04-22 |
Lifecell Corporation |
Prolonged preservation of blood platelets
|
US6051429A
(en)
|
1995-06-07 |
2000-04-18 |
Life Technologies, Inc. |
Peptide-enhanced cationic lipid transfections
|
US6017700A
(en)
|
1995-08-04 |
2000-01-25 |
Bayer Corporation |
Cationic oligonucleotides, and related methods of synthesis and use
|
CA2264012C
(en)
|
1996-08-13 |
2011-04-26 |
Chiron Corporation |
Compositions and methods for polynucleotide delivery
|
WO1998007734A1
(en)
|
1996-08-21 |
1998-02-26 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
US5891641A
(en)
|
1997-02-21 |
1999-04-06 |
The Regents Of The University Of California |
Assay for disease related conformation of a protein
|
US6214366B1
(en)
|
1999-06-01 |
2001-04-10 |
The Regents Of The University Of California |
Clearance and inhibition of conformationally altered proteins
|
US6720355B2
(en)
|
1997-02-21 |
2004-04-13 |
The Regents Of The University Of California |
Sodium dodecyl sulfate compositions for inactivating prions
|
US6423334B1
(en)
|
1997-10-01 |
2002-07-23 |
Elan Corporation, Plc |
Composition and method for enhancing transport across gastrointestinal tract cell layers
|
CA2314267A1
(en)
|
1997-12-10 |
1999-06-17 |
Washington University |
Anti-pathogen system and methods of use thereof
|
WO1999054459A2
(en)
*
|
1998-04-20 |
1999-10-28 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
US6531590B1
(en)
|
1998-04-24 |
2003-03-11 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligonucleotide compounds
|
US6348185B1
(en)
|
1998-06-20 |
2002-02-19 |
Washington University School Of Medicine |
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
|
US6407077B1
(en)
|
1998-11-05 |
2002-06-18 |
Emory University |
β-L nucleosides for the treatment of HIV infection
|
US6903077B1
(en)
|
1999-01-04 |
2005-06-07 |
University Of Vermont And State Agricultural College |
Methods and products for delivering nucleic acids
|
AU2405900A
(en)
|
1999-01-04 |
2000-07-24 |
University Of Vermont And State Agricultural College, The |
Methods and products for delivering nucleic acids
|
US6656730B1
(en)
*
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
US6309663B1
(en)
|
1999-08-17 |
2001-10-30 |
Lipocine Inc. |
Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
|
US20030104622A1
(en)
|
1999-09-01 |
2003-06-05 |
Robbins Paul D. |
Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
|
CA2392490A1
(en)
|
1999-11-24 |
2001-05-31 |
Mcs Micro Carrier Systems Gmbh |
Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
WO2002081628A2
(en)
|
2001-04-05 |
2002-10-17 |
Ribozyme Pharmaceuticals, Incorporated |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
|
EP1301213B1
(en)
|
2000-07-21 |
2017-01-18 |
ReVance Therapeutics, Inc. |
Multi-component biological transport systems
|
AU2001280767A1
(en)
|
2000-07-31 |
2002-02-13 |
Active Motif |
Peptide-mediated delivery of molecules into cells
|
CA2425610A1
(en)
|
2000-10-13 |
2002-04-18 |
University Of Lausanne |
Intracellular delivery of biological effectors by novel transporter peptide sequences
|
US6900540B1
(en)
|
2000-12-07 |
2005-05-31 |
Cadence Design Systems, Inc. |
Simulating diagonal wiring directions using Manhattan directional wires
|
CA2437983C
(en)
|
2001-02-16 |
2011-10-25 |
Cellgate, Inc. |
Transporters comprising spaced arginine moieties
|
KR20030062789A
(ko)
|
2002-01-19 |
2003-07-28 |
포휴먼텍(주) |
생체분자 전달 펩타이드 sim2-btm 및 이것을포함하는 생명공학제품
|
KR100468316B1
(ko)
|
2002-01-29 |
2005-01-27 |
주식회사 웰진 |
Dna의 세포 또는 조직 내 전달 효율을 높이는 펩타이드
|
US7101844B2
(en)
|
2002-03-29 |
2006-09-05 |
Creagene, Inc. |
Cytoplasmic transduction peptides and uses thereof
|
US6835810B2
(en)
|
2002-05-13 |
2004-12-28 |
Geneshuttle Biopharma, Inc. |
Fusion protein for use as vector
|
AU2003281078A1
(en)
|
2002-07-17 |
2004-02-02 |
University Of Otago |
Conjugate for double-stranded rna sequence releasing and methods thereof
|
ES2345330T3
(es)
|
2002-10-02 |
2010-09-21 |
The University Of British Columbia |
Oligonucleotidos para el tratamiento del cancer de prostata y otros canceres.
|
ES2343318T3
(es)
|
2002-11-26 |
2010-07-28 |
University Of Massachusetts |
Administracion de arnsis.
|
JP2006508675A
(ja)
|
2002-12-09 |
2006-03-16 |
トゥールゲン・インコーポレイテッド |
調節性ジンクフィンガータンパク質
|
US20060178297A1
(en)
|
2003-01-28 |
2006-08-10 |
Troy Carol M |
Systems and methods for silencing expression of a gene in a cell and uses thereof
|
US20040147027A1
(en)
|
2003-01-28 |
2004-07-29 |
Troy Carol M. |
Complex for facilitating delivery of dsRNA into a cell and uses thereof
|
US7166692B2
(en)
|
2003-03-04 |
2007-01-23 |
Canbrex Bio Science Walkersville, Inc. |
Intracellular delivery of small molecules, proteins, and nucleic acids
|
US7329638B2
(en)
|
2003-04-30 |
2008-02-12 |
The Regents Of The University Of Michigan |
Drug delivery compositions
|
EP1631676A4
(en)
|
2003-06-10 |
2006-12-20 |
Toolgen Inc |
TRANSDUCIBLE DNA BINDING PROTEINS
|
CA2529752A1
(en)
|
2003-06-20 |
2005-09-15 |
The Regents Of The University Of California |
Polypeptide transduction and fusogenic peptides
|
WO2005003315A2
(en)
|
2003-07-01 |
2005-01-13 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Compositions and methods for peptide-assisted transfection
|
JP4838722B2
(ja)
|
2003-10-24 |
2011-12-14 |
ゲンシア コーポレーション |
ポリヌクレオチドを送達する方法、及び送達用組成物
|
US8404249B2
(en)
|
2004-03-03 |
2013-03-26 |
Revance Therapeutics, Inc. |
Compositions and methods for topical application and transdermal delivery of botulinum toxins
|
US7514530B2
(en)
|
2004-04-26 |
2009-04-07 |
Centre National De La Recherche Scientifique |
Peptide carrier for delivering siRNA into mammalian cells
|
CA2565685A1
(en)
|
2004-05-04 |
2005-12-15 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
US20060040882A1
(en)
|
2004-05-04 |
2006-02-23 |
Lishan Chen |
Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
US20060035815A1
(en)
|
2004-05-04 |
2006-02-16 |
Nastech Pharmaceutical Company Inc. |
Pharmaceutical compositions for delivery of ribonucleic acid to a cell
|
US20060030003A1
(en)
|
2004-05-12 |
2006-02-09 |
Simon Michael R |
Composition and method for introduction of RNA interference sequences into targeted cells and tissues
|
US20050288246A1
(en)
|
2004-05-24 |
2005-12-29 |
Iversen Patrick L |
Peptide conjugated, inosine-substituted antisense oligomer compound and method
|
FR2871548B1
(fr)
|
2004-06-14 |
2006-08-11 |
Renault Sas |
Dispositif de retenue de deux elements l'un par rapport a l'autre
|
US7084248B2
(en)
|
2004-07-14 |
2006-08-01 |
Gene Tools, Llc |
Peptide composition and method for delivering substances into the cytosol of cells
|
JP4903146B2
(ja)
|
2004-08-16 |
2012-03-28 |
イミューン ディズィーズ インスティテュート インコーポレイテッド |
Rna干渉を送達する方法およびその使用法
|
US20080027025A1
(en)
|
2004-08-27 |
2008-01-31 |
The Regents Of The University Of California |
Protection From And Treatment Of Prion Protein Infection
|
US20090098049A1
(en)
|
2004-09-07 |
2009-04-16 |
The Regents Of The University Of California |
Targeting transducible molecules to specific cell types
|
AU2007215275B2
(en)
|
2006-02-10 |
2013-01-17 |
The Regents Of The University Of California |
Transducible delivery of siRNA by dsRNA binding domain fusions to PTD/CPPS
|
EP2046964B1
(en)
|
2006-07-12 |
2018-07-04 |
The Regents of The University of California |
Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
|
US8691971B2
(en)
|
2008-09-23 |
2014-04-08 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
|
WO2010129853A2
(en)
|
2009-05-07 |
2010-11-11 |
The Regents Of The University Of California |
TRANSDUCIBLE DELIVERY OF NUCLEIC ACIDS USING MODIFIED dsRNA BINDING DOMAINS
|
US20120142763A1
(en)
*
|
2009-06-01 |
2012-06-07 |
The Regents Of The University Of California |
Nucleic acid delivery compositions and methods of use thereof
|
EP2451461A4
(en)
*
|
2009-07-06 |
2013-05-29 |
Ontorii Inc |
NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
|