IN2015DN00634A - - Google Patents

Info

Publication number
IN2015DN00634A
IN2015DN00634A IN634DEN2015A IN2015DN00634A IN 2015DN00634 A IN2015DN00634 A IN 2015DN00634A IN 634DEN2015 A IN634DEN2015 A IN 634DEN2015A IN 2015DN00634 A IN2015DN00634 A IN 2015DN00634A
Authority
IN
India
Prior art keywords
aptamers
present disclosure
disclosure relates
specifically bind
demonstrate superior
Prior art date
Application number
Other languages
English (en)
Inventor
Wei Duan
Original Assignee
Univ Deakin
Wei Duan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2012903332A external-priority patent/AU2012903332A0/en
Application filed by Univ Deakin, Wei Duan filed Critical Univ Deakin
Publication of IN2015DN00634A publication Critical patent/IN2015DN00634A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IN634DEN2015 2012-08-02 2013-08-02 IN2015DN00634A (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2012903332A AU2012903332A0 (en) 2012-08-02 CD133 Aptamers for Detection of Cancer Stem Cells
PCT/AU2013/000850 WO2014019024A1 (en) 2012-08-02 2013-08-02 Cd133 aptamers for detection of cancer stem cells

Publications (1)

Publication Number Publication Date
IN2015DN00634A true IN2015DN00634A (xx) 2015-06-26

Family

ID=50026987

Family Applications (1)

Application Number Title Priority Date Filing Date
IN634DEN2015 IN2015DN00634A (xx) 2012-08-02 2013-08-02

Country Status (16)

Country Link
US (1) US9840712B2 (xx)
EP (1) EP2880185B1 (xx)
JP (1) JP6279573B2 (xx)
KR (1) KR20150085806A (xx)
CN (1) CN104781417B (xx)
AU (1) AU2013299331B2 (xx)
BR (1) BR112015002289A2 (xx)
CA (1) CA2880589A1 (xx)
ES (1) ES2741949T3 (xx)
IL (1) IL237034A0 (xx)
IN (1) IN2015DN00634A (xx)
MX (1) MX2015001433A (xx)
NZ (1) NZ704719A (xx)
SG (1) SG11201500666TA (xx)
WO (1) WO2014019024A1 (xx)
ZA (1) ZA201501318B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015117201A1 (en) * 2014-02-05 2015-08-13 Deakin University Aptamer construct
KR101612272B1 (ko) 2014-06-20 2016-04-15 한양대학교 산학협력단 신경교종 줄기세포 검출용 펩타이드
EP3256593B1 (en) 2015-02-11 2020-03-25 Deakin University Epcam aptamers and conjugates thereof
CN104745590A (zh) * 2015-03-23 2015-07-01 莱萌科医疗技术有限公司 可检测癌症病人血清内enox2蛋白的核酸适配子及其应用
KR101726212B1 (ko) * 2015-05-08 2017-04-13 한양대학교 산학협력단 Cd133 검출용 다중 펩타이드 프로브
CN105602904B (zh) * 2015-08-24 2019-05-31 天津市第四中心医院 Cd133质粒的新用途
KR20190023197A (ko) 2017-08-28 2019-03-08 피엠씨씨 주식회사 암 줄기세포 검출을 위한 재조합 발현벡터와 이로부터 형질전환된 세포주 그리고 이의 제조방법
WO2019157651A1 (zh) 2018-02-13 2019-08-22 深圳麦克韦尔股份有限公司 电子烟及其发热组件和发热体
CN108866062A (zh) * 2018-06-21 2018-11-23 中山大学附属第五医院 一种特异性识别肝癌干细胞的dna适配体及其筛选方法与应用
CN108866061A (zh) * 2018-06-21 2018-11-23 中山大学附属第五医院 一种识别肝癌细胞的核酸适配体及其筛选方法与用途
CN109536503B (zh) * 2018-12-06 2021-03-02 浙江省肿瘤医院 一种靶向结合cd133蛋白的核酸适配体及其筛选方法和用途
KR102212149B1 (ko) * 2019-03-28 2021-02-04 부산대학교 산학협력단 암 줄기세포에 특이적으로 결합하는 압타머 및 이의 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261774B1 (en) 1990-06-11 2001-07-17 Gilead Sciences, Inc. Truncation selex method
US5637459A (en) * 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
KR970002255B1 (ko) * 1990-06-11 1997-02-26 넥스스타 파아마슈티컬드, 인크. 핵산 리간드
AU2003206865B2 (en) 2002-02-08 2007-10-04 D. Collen Research Foundation Vzw A novel target to inhibit angiogenesis
WO2004084950A2 (en) * 2003-03-24 2004-10-07 Case Western Reserve University Cell targeting methods and compositions
IL179285A (en) * 2004-05-14 2011-04-28 Rosetta Genomics Ltd Micrornas and uses thereof
CA2629330C (en) * 2004-11-12 2018-05-22 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
JP2007319153A (ja) 2006-06-02 2007-12-13 Takashi Otsu 核酸リガンドと中和剤との組み合わせ製剤
WO2009009739A2 (en) * 2007-07-12 2009-01-15 Theracrine, Inc. Methods and compositions for facilitating cell death of cancer stem cells and for treating cancer
US20110206614A1 (en) 2007-11-23 2011-08-25 Whitehead Institute For Biomedical Research Systemic instigation systems to study tumor growth or metastasis

Also Published As

Publication number Publication date
WO2014019024A1 (en) 2014-02-06
JP2015526075A (ja) 2015-09-10
CA2880589A1 (en) 2014-02-06
AU2013299331A1 (en) 2015-02-26
JP6279573B2 (ja) 2018-02-14
KR20150085806A (ko) 2015-07-24
EP2880185B1 (en) 2019-07-03
CN104781417B (zh) 2017-12-12
ZA201501318B (en) 2016-07-27
US20150299708A1 (en) 2015-10-22
CN104781417A (zh) 2015-07-15
ES2741949T3 (es) 2020-02-12
IL237034A0 (en) 2015-03-31
EP2880185A4 (en) 2016-04-06
SG11201500666TA (en) 2015-02-27
EP2880185A1 (en) 2015-06-10
AU2013299331B2 (en) 2018-07-26
US9840712B2 (en) 2017-12-12
MX2015001433A (es) 2015-09-16
BR112015002289A2 (pt) 2017-07-04
NZ704719A (en) 2018-02-23

Similar Documents

Publication Publication Date Title
IN2015DN00634A (xx)
IN2015DN00636A (xx)
HK1208165A1 (en) Drug-conjugates, conjugation methods, and uses thereof
HK1206774A1 (en) Biophotonic compositions, kits and methods
HK1207092A1 (en) Anti-hla-b27 antibodies and uses thereof -hla-b27
EP2877490A4 (en) CLIENTS, CONJUGATES AND USES THEREOF
PT2922554T (pt) Arn modificado nas porções terminais
HK1210949A1 (en) Combinations and uses thereof
HK1199269A1 (en) Anti-asic1 antibodies and uses thereof -asic1
GB201218085D0 (en) Torrified wood briquette manufacture
EP2951300A4 (en) ROBUST AND EASY IMMOBILIZED ENZYME REACTORS TO BE USED
IL235609B (en) Broadband repeater with low latency, and methods
EP2900693A4 (en) ADCC-mediating antibodies, combinations and uses thereof
HK1211323A1 (en) Dual enzymatic amplification
GB2507076B (en) Trading desk
AU342728S (en) Backplate for handle assembly
UA80618U (xx) Застосування n-стероїлетаноламіну як радіомодифікуючого засобу[применение n-стероилэтаноламина как радиомодифицирующего средства
AU344026S (en) Bracket
GB201211978D0 (en) Enzyme
UA106373C2 (ru) Применение поллентара как средства фригопротекторного действия
TWM432402U (en) Spine activator structure