IN2015DN00202A - - Google Patents
Download PDFInfo
- Publication number
- IN2015DN00202A IN2015DN00202A IN202DEN2015A IN2015DN00202A IN 2015DN00202 A IN2015DN00202 A IN 2015DN00202A IN 202DEN2015 A IN202DEN2015 A IN 202DEN2015A IN 2015DN00202 A IN2015DN00202 A IN 2015DN00202A
- Authority
- IN
- India
- Prior art keywords
- mula
- inhibitors
- compounds
- formula
- neutrophil elastase
- Prior art date
Links
- 235000013350 formula milk Nutrition 0.000 abstract 2
- 108010028275 Leukocyte Elastase Proteins 0.000 abstract 1
- 102000016799 Leukocyte elastase Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176079 | 2012-07-12 | ||
| EP13158756 | 2013-03-12 | ||
| PCT/EP2013/064603 WO2014009425A1 (en) | 2012-07-12 | 2013-07-10 | Inhibition of enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN00202A true IN2015DN00202A (enrdf_load_stackoverflow) | 2015-06-12 |
Family
ID=48953361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN202DEN2015 IN2015DN00202A (enrdf_load_stackoverflow) | 2012-07-12 | 2013-07-10 |
Country Status (10)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2933725A1 (en) | 2013-12-16 | 2015-06-25 | Chiesi Farmaceutici S.P.A. | Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors |
| US9487528B2 (en) | 2014-06-09 | 2016-11-08 | Chiesi Farmaceutici S.P.A. | Compounds |
| US9440930B2 (en) | 2014-07-31 | 2016-09-13 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9657015B2 (en) | 2014-07-31 | 2017-05-23 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9475779B2 (en) | 2014-07-31 | 2016-10-25 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9409870B2 (en) | 2014-12-15 | 2016-08-09 | Chiesi Farmaceutici S.P.A. | Compounds |
| WO2017207433A1 (en) * | 2016-05-31 | 2017-12-07 | Chiesi Farmaceutici S.P.A. | Hetetocyclic compounds for use in the treatment of a disease in which hne is implicated |
| WO2017207432A1 (en) * | 2016-05-31 | 2017-12-07 | Chiesi Farmaceutici S.P.A. | Novel compounds |
| AU2017272405C1 (en) * | 2016-05-31 | 2021-01-14 | Chiesi Farmaceutici S.P.A. | Imidazolone compounds as human Neutrophil Elastase inhibitors |
| US11106356B2 (en) | 2017-02-27 | 2021-08-31 | Géza Bálint | Smart device with a display that enables simultaneous multi-functional handling of the displayed information and/or data |
| CA3148209A1 (en) | 2019-07-23 | 2021-01-28 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
| UY38794A (es) | 2019-07-23 | 2021-02-26 | Bayer Ag | Novedosos compuestos de heteroaril-triazol como plaguicidas |
| CA3154761A1 (en) | 2019-09-17 | 2021-03-25 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| TW202128664A (zh) | 2019-10-09 | 2021-08-01 | 德商拜耳廠股份有限公司 | 作為除害劑之新穎雜芳基三唑化合物 |
| TW202128663A (zh) | 2019-10-09 | 2021-08-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基三唑化合物 |
| EP4051388A1 (en) * | 2019-11-01 | 2022-09-07 | Bristol-Myers Squibb Company | Substituted pyrazole compounds as toll receptor inhibitors |
| TW202134226A (zh) | 2019-11-18 | 2021-09-16 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基-三唑化合物 |
| HUE064089T2 (hu) | 2020-04-16 | 2024-02-28 | Mereo Biopharma 4 Ltd | Alvelesztat neutrofil elasztáz inhibitort alkalmazó módszerek alfa-1-antitripszin hiány által közvetített légzõszervi megbetegedés kezelésére |
| US20230303562A1 (en) * | 2020-09-28 | 2023-09-28 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Pyrazole compound and preparation method therefor and use thereof |
| CN113480486B (zh) * | 2021-07-30 | 2022-05-24 | 赣南师范大学 | 一种3-胺基-1,2,4-三唑类衍生物及其制备方法和应用 |
| KR20240090272A (ko) | 2021-10-20 | 2024-06-21 | 메레오 바이오파마 4 리미티드 | 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259504A (en) | 1979-08-27 | 1981-03-31 | American Cyanamid Company | Substituted 1H-1,2,4-triazoles |
| US4451471A (en) | 1981-03-18 | 1984-05-29 | Ciba-Geigy Corporation | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same |
| US4576958A (en) | 1984-01-23 | 1986-03-18 | E. I. Du Pont De Nemours And Company | Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| ES2184633B1 (es) | 2001-08-07 | 2004-08-01 | J. URIACH & CIA, S.A. | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida. |
| US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
| CA2582482A1 (en) | 2004-10-07 | 2006-04-13 | Warner-Lambert Company Llc | Triazolopyridine derivatives as antibacterial agents |
| US7902374B2 (en) | 2005-05-06 | 2011-03-08 | Universal Display Corporation | Stability OLED materials and devices |
| WO2007139952A2 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Method for the preparation of triazole compounds with hsp90 modulating activity |
| PE20091565A1 (es) * | 2007-11-06 | 2009-11-06 | Astrazeneca Ab | Derivados de 2-pirazinona como inhibidores de la elastasa de los neutrofilos |
| PE20091953A1 (es) | 2008-05-08 | 2010-01-09 | Du Pont | Azoles sustituidos como fungicidas |
| WO2009155388A1 (en) * | 2008-06-20 | 2009-12-23 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors |
| CN102131806A (zh) * | 2008-06-20 | 2011-07-20 | 百时美施贵宝公司 | 用作激酶抑制剂的三唑并吡啶化合物 |
| DE102009004197A1 (de) * | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung |
| CN102639505A (zh) * | 2009-10-02 | 2012-08-15 | 阿斯利康(瑞典)有限公司 | 用作嗜中性白细胞弹性蛋白酶抑制剂的吡啶-2-酮化合物 |
-
2013
- 2013-07-10 CN CN201380036973.4A patent/CN104428300B/zh not_active Expired - Fee Related
- 2013-07-10 BR BR112015000507A patent/BR112015000507A2/pt not_active IP Right Cessation
- 2013-07-10 RU RU2015104644A patent/RU2638537C2/ru not_active IP Right Cessation
- 2013-07-10 CA CA2878792A patent/CA2878792A1/en not_active Abandoned
- 2013-07-10 IN IN202DEN2015 patent/IN2015DN00202A/en unknown
- 2013-07-10 EP EP13747801.2A patent/EP2872509B1/en active Active
- 2013-07-10 KR KR20157002129A patent/KR20150031318A/ko not_active Withdrawn
- 2013-07-10 WO PCT/EP2013/064603 patent/WO2014009425A1/en active Application Filing
- 2013-07-11 AR ARP130102470 patent/AR091737A1/es unknown
- 2013-07-12 US US13/940,555 patent/US9199984B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN104428300A (zh) | 2015-03-18 |
| AR091737A1 (es) | 2015-02-25 |
| US20140018345A1 (en) | 2014-01-16 |
| KR20150031318A (ko) | 2015-03-23 |
| RU2015104644A (ru) | 2016-08-27 |
| US9199984B2 (en) | 2015-12-01 |
| EP2872509B1 (en) | 2016-09-14 |
| RU2638537C2 (ru) | 2017-12-14 |
| BR112015000507A2 (pt) | 2017-06-27 |
| EP2872509A1 (en) | 2015-05-20 |
| HK1207078A1 (en) | 2016-01-22 |
| CA2878792A1 (en) | 2014-01-16 |
| WO2014009425A1 (en) | 2014-01-16 |
| CN104428300B (zh) | 2016-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2015DN00202A (enrdf_load_stackoverflow) | ||
| UY34092A (es) | Nuevos compuestos como inhibidores de jak | |
| AU2013291345B2 (en) | Composition for controlling plant disease and application therefor | |
| UY34051A (es) | Derivados de pirrolotriazinona como inhibidores de pi3k | |
| CR20140024A (es) | Compuestos inhibidores de metaloenzimas | |
| MY163187A (en) | Novel imidazo-oxazine compound or salt thereof | |
| UY34156A (es) | Compuestos inhibidores de metaloenzimas | |
| PH12014502169A1 (en) | N-cyclylamides as nematicides | |
| UY34145A (es) | Compuestos inhibidores de metaloenzimas | |
| UY34654A (es) | Inhibidores de la beta-secretasa | |
| UY33958A (es) | Inhibidores de la glucosilceramida sintasa | |
| PH12012501650B1 (en) | Heterocyclic compound | |
| IL228239A0 (en) | 3,4-dihydro--pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace) | |
| EA201400833A1 (ru) | Новые индолизиновые соединения, способ их получения и фармацевтические композиции, содержащие их | |
| MX341456B (es) | Amino-quinolinas como inhibidores de cinasa. | |
| UY33930A (es) | Inhibidores novedosos de quinasas | |
| UY33929A (es) | Compuestos de ciclohexilo tetrasustituido como inhibidores de quinasas | |
| UY34523A (es) | Derivados de betulina | |
| IN2015DN00598A (enrdf_load_stackoverflow) | ||
| IN2015DN01061A (enrdf_load_stackoverflow) | ||
| CR20130539A (es) | Triazolopiridinas | |
| UA111744C2 (uk) | ЗАМІЩЕНІ ПІРИДОПІРАЗИНИ ЯК ІНГІБІТОРИ Syk | |
| TN2013000400A1 (en) | Imidazopyridazines as akt kinase inhibitors | |
| IN2014MN01637A (enrdf_load_stackoverflow) | ||
| JO3063B1 (ar) | مركب مبتكر وطرق لانتاجه |