IN2014KN01491A - - Google Patents
Info
- Publication number
- IN2014KN01491A IN2014KN01491A IN1491KON2014A IN2014KN01491A IN 2014KN01491 A IN2014KN01491 A IN 2014KN01491A IN 1491KON2014 A IN1491KON2014 A IN 1491KON2014A IN 2014KN01491 A IN2014KN01491 A IN 2014KN01491A
- Authority
- IN
- India
- Prior art keywords
- synthesis
- ticagrelor
- describes
- preparation
- field
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11195508.4A EP2607355A1 (fr) | 2011-12-23 | 2011-12-23 | Synthèse de triazolopyrimidines |
| EP12169185 | 2012-05-24 | ||
| PCT/EP2012/076458 WO2013092900A1 (fr) | 2011-12-23 | 2012-12-20 | Synthèse de composés de triazolopyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014KN01491A true IN2014KN01491A (fr) | 2015-10-23 |
Family
ID=47520984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1491KON2014 IN2014KN01491A (fr) | 2011-12-23 | 2012-12-20 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9278972B2 (fr) |
| EP (1) | EP2794575B1 (fr) |
| CN (1) | CN104114542B (fr) |
| CA (1) | CA2859580A1 (fr) |
| IN (1) | IN2014KN01491A (fr) |
| WO (1) | WO2013092900A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ307217B6 (cs) * | 2013-03-14 | 2018-04-04 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy ticagreloru |
| CN104098553B (zh) * | 2013-04-10 | 2017-11-28 | 江苏恒瑞医药股份有限公司 | 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法 |
| CN104610237B (zh) * | 2013-11-05 | 2018-03-30 | 正大天晴药业集团股份有限公司 | 一种替格瑞洛的制备方法及其中间体 |
| CN103588750B (zh) * | 2013-11-07 | 2014-11-26 | 苏州明锐医药科技有限公司 | 替卡格雷中间体的制备方法 |
| CZ2013866A3 (cs) * | 2013-11-08 | 2015-05-20 | Zentiva, K.S. | Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru |
| CN104710425B (zh) * | 2013-12-16 | 2019-06-14 | 石药集团中奇制药技术（石家庄）有限公司 | 一种替格瑞洛新结晶及其制备方法 |
| EP3292867B1 (fr) * | 2016-09-09 | 2019-05-15 | Université de Liège | Dérivés triazolo(4,5-d)pyrimidines pour la prevention et le traitement d'infections bacteriennes |
| US10905691B2 (en) | 2016-09-09 | 2021-02-02 | Université de Liège | Use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection |
| WO2019169111A1 (fr) | 2018-03-02 | 2019-09-06 | The Trustees Of The University Of Pennsylvania | Composés de [1,2,4]triazolo[1,5-a]pyrimidine et utilisation de ces derniers dans la stabilisation de microtubules |
| CN109896934A (zh) * | 2019-03-08 | 2019-06-18 | 山东省药学科学院 | 一种高纯度2-苄氧基溴乙烷的制备方法 |
| CN110467619A (zh) * | 2019-08-08 | 2019-11-19 | 山西德元堂药业有限公司 | 一种替格瑞洛的制备方法 |
| CN112047919B (zh) * | 2020-09-16 | 2021-06-18 | 常州制药厂有限公司 | 一种替卡格雷中间体及其制备方法 |
| CN113801090B (zh) * | 2021-11-18 | 2022-02-18 | 南京威凯尔生物医药科技有限公司 | 一种替格瑞洛关键中间体及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI229674B (en) * | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| GB0013488D0 (en) | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
| AU2009292269B2 (en) * | 2008-09-09 | 2012-11-01 | Astrazeneca Ab | A process for preparing [1S- [1-alpha, 2-alpha, 3-beta (1S*, 2R*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3H-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates |
| WO2011017108A2 (fr) * | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Modulateurs cyclopropylés du récepteur p2y12 |
| ES2556959T3 (es) | 2009-08-31 | 2016-01-21 | Lonza Ltd. | Proceso para la preparación de (1S,4R)-2-oxa-3-azabiciclo[2.2.1]hept-5-enos |
| US9056838B2 (en) * | 2011-04-06 | 2015-06-16 | Teva Pharmaceutical Industries Ltd. | Intermediates and processes for preparing Ticagrelor |
| CN102731467B (zh) | 2011-04-15 | 2015-12-16 | 博瑞生物医药（苏州）股份有限公司 | 替卡格雷的中间体及制备替卡格雷的方法 |
| PL2755957T4 (pl) * | 2011-09-14 | 2017-05-31 | Lek Pharmaceuticals D.D. | Synteza związków triazolopirymidynowych |
-
2012
- 2012-12-20 CN CN201280069533.4A patent/CN104114542B/zh active Active
- 2012-12-20 CA CA2859580A patent/CA2859580A1/fr not_active Abandoned
- 2012-12-20 IN IN1491KON2014 patent/IN2014KN01491A/en unknown
- 2012-12-20 EP EP12812638.0A patent/EP2794575B1/fr active Active
- 2012-12-20 US US14/366,764 patent/US9278972B2/en not_active Expired - Fee Related
- 2012-12-20 WO PCT/EP2012/076458 patent/WO2013092900A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP2794575B1 (fr) | 2018-12-05 |
| EP2794575A1 (fr) | 2014-10-29 |
| WO2013092900A1 (fr) | 2013-06-27 |
| CA2859580A1 (fr) | 2013-06-27 |
| CN104114542B (zh) | 2017-11-14 |
| US9278972B2 (en) | 2016-03-08 |
| US20140371449A1 (en) | 2014-12-18 |
| CN104114542A (zh) | 2014-10-22 |
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