IN2014KN01062A - - Google Patents

Info

Publication number
IN2014KN01062A
IN2014KN01062A IN1062KON2014A IN2014KN01062A IN 2014KN01062 A IN2014KN01062 A IN 2014KN01062A IN 1062KON2014 A IN1062KON2014 A IN 1062KON2014A IN 2014KN01062 A IN2014KN01062 A IN 2014KN01062A
Authority
IN
India
Prior art keywords
synthesis
intermediates
describes
well
field
Prior art date
Application number
Other languages
English (en)
Inventor
Borut Zupancic
Nenad Maras
Damjan Sterk
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11186817.0A external-priority patent/EP2586773A1/en
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Publication of IN2014KN01062A publication Critical patent/IN2014KN01062A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56One oxygen atom and one sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN1062KON2014 2011-10-27 2012-10-26 IN2014KN01062A (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11186817.0A EP2586773A1 (en) 2011-10-27 2011-10-27 Synthesis of Triazolopyrimidine Compounds
EP11195608 2011-12-23
PCT/EP2012/071252 WO2013060837A1 (en) 2011-10-27 2012-10-26 Synthesis of triazolopyrimidine compounds

Publications (1)

Publication Number Publication Date
IN2014KN01062A true IN2014KN01062A (is) 2015-10-09

Family

ID=47148745

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1062KON2014 IN2014KN01062A (is) 2011-10-27 2012-10-26

Country Status (10)

Country Link
US (1) US9469614B2 (is)
EP (1) EP2771326B1 (is)
CN (1) CN104024230B (is)
CA (1) CA2852652A1 (is)
ES (1) ES2665546T3 (is)
HR (1) HRP20180466T1 (is)
HU (1) HUE036244T2 (is)
IN (1) IN2014KN01062A (is)
PL (1) PL2771326T3 (is)
WO (1) WO2013060837A1 (is)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103965198A (zh) * 2013-02-05 2014-08-06 郝聪梅 替卡格雷的中间体及其制备方法以及利用该中间体制备替卡格雷的方法
CN104098553B (zh) * 2013-04-10 2017-11-28 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
CN103275056B (zh) * 2013-05-24 2015-06-17 浙江普洛医药科技有限公司 一种替卡格雷中间体的制备方法
CN103360396B (zh) * 2013-06-27 2015-07-01 苏州明锐医药科技有限公司 一种替格瑞洛的制备方法
LT3483163T (lt) 2013-09-06 2021-09-10 F. Hoffmann-La Roche Ag Triazol[4,5-d]pirimidino dariniai kaip cb2 receptorių antagonistai
EP3157907B1 (en) 2014-06-18 2018-08-29 Flamma S.P.A. Process for the preparation of triazolo[4,5-d]pyrimidine cyclopentane compounds
CN105985346B (zh) * 2015-03-06 2019-10-18 苏州朗科生物技术股份有限公司 一种新的替格瑞洛化合物制备方法及其中间体化合物
WO2019169111A1 (en) 2018-03-02 2019-09-06 The Trustees Of The University Of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702773D0 (sv) 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
AR017014A1 (es) * 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
AU2009292269B2 (en) * 2008-09-09 2012-11-01 Astrazeneca Ab A process for preparing [1S- [1-alpha, 2-alpha, 3-beta (1S*, 2R*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3H-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates
WO2011017108A2 (en) 2009-07-27 2011-02-10 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of p2y12 receptor

Also Published As

Publication number Publication date
HUE036244T2 (hu) 2018-06-28
EP2771326A1 (en) 2014-09-03
HRP20180466T1 (hr) 2018-07-27
CN104024230A (zh) 2014-09-03
WO2013060837A1 (en) 2013-05-02
ES2665546T3 (es) 2018-04-26
US20140256747A1 (en) 2014-09-11
PL2771326T4 (pl) 2018-06-29
CN104024230B (zh) 2016-05-04
CA2852652A1 (en) 2013-05-02
US9469614B2 (en) 2016-10-18
PL2771326T3 (pl) 2018-06-29
EP2771326B1 (en) 2017-12-20

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