IN2014DN10758A - - Google Patents
Info
- Publication number
- IN2014DN10758A IN2014DN10758A IN10758DEN2014A IN2014DN10758A IN 2014DN10758 A IN2014DN10758 A IN 2014DN10758A IN 10758DEN2014 A IN10758DEN2014 A IN 10758DEN2014A IN 2014DN10758 A IN2014DN10758 A IN 2014DN10758A
- Authority
- IN
- India
- Prior art keywords
- group
- alkyl group
- epoxyketone
- substituent
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 epoxyketone compound Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical class O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
- C07D301/19—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic hydroperoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012146821 | 2012-06-29 | ||
| US201261735196P | 2012-12-10 | 2012-12-10 | |
| JP2013026801 | 2013-02-14 | ||
| US201361789996P | 2013-03-15 | 2013-03-15 | |
| PCT/JP2013/068308 WO2014003203A2 (en) | 2012-06-29 | 2013-06-27 | Method for producing stereoselective epoxyketone compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN10758A true IN2014DN10758A (enrdf_load_stackoverflow) | 2015-09-04 |
Family
ID=49783967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN10758DEN2014 IN2014DN10758A (enrdf_load_stackoverflow) | 2012-06-29 | 2013-06-27 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9187442B2 (enrdf_load_stackoverflow) |
| EP (1) | EP2867202B1 (enrdf_load_stackoverflow) |
| JP (1) | JP6176259B2 (enrdf_load_stackoverflow) |
| CN (1) | CN104411682B (enrdf_load_stackoverflow) |
| IN (1) | IN2014DN10758A (enrdf_load_stackoverflow) |
| WO (1) | WO2014003203A2 (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104230857A (zh) * | 2014-08-19 | 2014-12-24 | 上海皓元生物医药科技有限公司 | 卡非佐米(Carfilzomib)的中间体化合物的制备方法及其中间体化合物 |
| WO2016185450A1 (en) | 2015-05-21 | 2016-11-24 | Laurus Labs Private Limited | An improved processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof |
| CN105017181B (zh) * | 2015-07-02 | 2017-10-10 | 南京师范大学 | 卡非佐米关键中间体及其衍生物的制备方法 |
| CN105622458A (zh) * | 2015-12-22 | 2016-06-01 | 中国药科大学 | (s)-4-氨基-2-甲基-5-苯基戊-1-烯-3-酮的制备方法 |
| IL263771B2 (en) | 2016-06-29 | 2023-09-01 | Kezar Life Sciences | Preparation process of immunoproteasome epoxytone peptide inhibitor and its precursors |
| PL3478670T3 (pl) | 2016-06-29 | 2023-07-24 | Kezar Life Sciences | Krystaliczne sole peptydowego epoksyketonowego inhibitora immunoproteasomu |
| EP3330260A1 (en) * | 2016-12-01 | 2018-06-06 | Enantia, S.L. | Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005243140A1 (en) * | 2004-05-10 | 2005-11-24 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
| SI2030981T1 (sl) * | 2004-05-10 | 2014-11-28 | Onyx Therapeutics, Inc. | Spojine za inhibiranje proteasomskega encima |
| JP2007538081A (ja) * | 2004-05-17 | 2007-12-27 | プロテオリックス， インコーポレイテッド | アミノ酸ケトエポキシドの合成 |
| WO2006001387A1 (ja) | 2004-06-25 | 2006-01-05 | Tohoku University | アルコール酸化触媒およびその合成方法 |
| WO2007149512A2 (en) | 2006-06-19 | 2007-12-27 | Proteolix, Inc. | Peptide epoxyketones for pr0teas0me inhibition |
| JP4803074B2 (ja) | 2007-03-06 | 2011-10-26 | 日産化学工業株式会社 | アルコール酸化触媒およびその合成方法 |
| US8013189B2 (en) * | 2007-09-21 | 2011-09-06 | Basf Se | Accelerated amide and ester reductions with amine boranes and additives |
| NZ584814A (en) | 2007-10-04 | 2012-03-30 | Onyx Therapeutics Inc | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
| US7902376B2 (en) * | 2008-01-23 | 2011-03-08 | Merck Sharp & Dohme Corp. | Process for preparing chiral dipeptidyl peptidase-IV inhibitor intermediates |
| WO2009145323A1 (ja) | 2008-05-30 | 2009-12-03 | 日産化学工業株式会社 | 多環式化合物を用いるアルコールの酸化方法 |
-
2013
- 2013-06-27 JP JP2014561639A patent/JP6176259B2/ja not_active Expired - Fee Related
- 2013-06-27 EP EP13739297.3A patent/EP2867202B1/en not_active Not-in-force
- 2013-06-27 CN CN201380033893.3A patent/CN104411682B/zh not_active Expired - Fee Related
- 2013-06-27 WO PCT/JP2013/068308 patent/WO2014003203A2/en active Application Filing
- 2013-06-27 US US14/391,033 patent/US9187442B2/en not_active Expired - Fee Related
- 2013-06-27 IN IN10758DEN2014 patent/IN2014DN10758A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6176259B2 (ja) | 2017-08-09 |
| WO2014003203A2 (en) | 2014-01-03 |
| EP2867202B1 (en) | 2017-08-09 |
| JP2015526384A (ja) | 2015-09-10 |
| CN104411682A (zh) | 2015-03-11 |
| US9187442B2 (en) | 2015-11-17 |
| EP2867202A2 (en) | 2015-05-06 |
| CN104411682B (zh) | 2016-11-16 |
| US20150126755A1 (en) | 2015-05-07 |
| WO2014003203A3 (en) | 2014-03-20 |
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