IN2014DN07983A - - Google Patents

Info

Publication number
IN2014DN07983A
IN2014DN07983A IN7983DEN2014A IN2014DN07983A IN 2014DN07983 A IN2014DN07983 A IN 2014DN07983A IN 7983DEN2014 A IN7983DEN2014 A IN 7983DEN2014A IN 2014DN07983 A IN2014DN07983 A IN 2014DN07983A
Authority
IN
India
Prior art keywords
aceton
dimethylbenzene
bromo
preparation
discloses
Prior art date
Application number
Other languages
English (en)
Inventor
Doerwald Florencio Zaragoza
Anna Kulesza
Stephan Elzner
Robert Bujok
Zbigniew Wrobel
Krzysztof Wojciechowski
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47558543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN07983(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2012/070870 external-priority patent/WO2012172119A2/en
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of IN2014DN07983A publication Critical patent/IN2014DN07983A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IN7983DEN2014 2012-05-08 2012-11-15 IN2014DN07983A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261644284P 2012-05-08 2012-05-08
EP12167134 2012-05-08
PCT/EP2012/070870 WO2012172119A2 (en) 2012-05-08 2012-10-22 Method for the preparation of medetomidine
EP12192612 2012-11-14
PCT/EP2012/072796 WO2013011155A2 (en) 2012-05-08 2012-11-15 Method for preparation of medetomidine

Publications (1)

Publication Number Publication Date
IN2014DN07983A true IN2014DN07983A (zh) 2015-05-01

Family

ID=47558543

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7983DEN2014 IN2014DN07983A (zh) 2012-05-08 2012-11-15

Country Status (21)

Country Link
US (1) US9045433B2 (zh)
EP (1) EP2847173B1 (zh)
JP (1) JP5779297B2 (zh)
KR (1) KR101530506B1 (zh)
CN (1) CN104245679B (zh)
AU (1) AU2012285675B2 (zh)
CA (1) CA2866424A1 (zh)
CL (1) CL2014002905A1 (zh)
CY (1) CY1117490T1 (zh)
DK (1) DK2847173T3 (zh)
EA (1) EA025950B1 (zh)
ES (1) ES2563816T3 (zh)
HK (1) HK1201532A1 (zh)
HR (1) HRP20160215T1 (zh)
HU (1) HUE027384T2 (zh)
IN (1) IN2014DN07983A (zh)
MY (1) MY166058A (zh)
PL (1) PL2847173T3 (zh)
SG (1) SG11201405606RA (zh)
TW (1) TWI529164B (zh)
WO (1) WO2013011155A2 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9126915B2 (en) * 2012-05-08 2015-09-08 Lonza Ltd. Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
DK2847173T3 (en) * 2012-05-08 2016-04-04 Lonza Ag METHOD OF PRODUCING Medetomidine
CN105218453B (zh) * 2012-06-28 2017-04-12 隆萨有限公司 用氯丙酮制备美托咪定的方法
CN104220408B (zh) * 2012-06-28 2016-01-20 隆萨有限公司 用氯丙酮制备2-(2,3-二甲基苯基)-1-丙醛的方法
CN106518812A (zh) * 2016-10-25 2017-03-22 湖南大学 一种美托咪定及其中间体的制备方法
CN111548308A (zh) * 2020-03-18 2020-08-18 遂成药业股份有限公司 一种盐酸右美托咪定的合成工艺
KR102341174B1 (ko) * 2021-09-13 2021-12-20 주식회사 세라수 양이온교환 섬유를 사용한 테레프탈릴리덴 디캠퍼 설폰산염의 산성화 방법
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790604A (fr) 1971-10-28 1973-04-26 Sandoz Sa Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
JPS51100041A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100042A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
EP0153692B1 (en) 1984-02-24 1992-07-29 Sagami Chemical Research Center Method for isomerization a glycidate derivative
JPS62103037A (ja) * 1985-10-29 1987-05-13 Hamari Yakuhin Kogyo Kk ２−（４−イソブチルフエニル）−プロピオンアルデヒドの製造法
DE19714042A1 (de) 1997-04-05 1998-10-08 Henkel Kgaa Verfahren zur Herstellung aromatischer Aldehyde
SE513474C2 (sv) 1999-01-25 2000-09-18 Hans Elwing Instutionen Foer C Metod för att förhindra kräftdjurs, särskilt havstulpaners, etablering på fasta ytor med hjälp av en substans som stör nervsignaler, varvid substansen är medetomidin, dvs (+)-4-/1- (2,3-dimetylfenyl)-etyl/-IH-imidazol
EP1918282A1 (en) 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Method for preparing medetomidine and its salts
GB2453982B (en) 2007-10-24 2009-09-16 Norbrook Lab Ltd Chemical process for the preparation of Medetomidine
US7902247B2 (en) 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
CN102753532B (zh) 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
US9126915B2 (en) * 2012-05-08 2015-09-08 Lonza Ltd. Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
WO2012172120A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume
DK2847173T3 (en) * 2012-05-08 2016-04-04 Lonza Ag METHOD OF PRODUCING Medetomidine
CN104220408B (zh) * 2012-06-28 2016-01-20 隆萨有限公司 用氯丙酮制备2-(2,3-二甲基苯基)-1-丙醛的方法
WO2012172122A2 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
CN105218453B (zh) * 2012-06-28 2017-04-12 隆萨有限公司 用氯丙酮制备美托咪定的方法

Also Published As

Publication number Publication date
HRP20160215T1 (hr) 2016-03-25
KR20140136523A (ko) 2014-11-28
TWI529164B (zh) 2016-04-11
US20150057453A1 (en) 2015-02-26
EA201400940A1 (ru) 2015-01-30
CY1117490T1 (el) 2017-04-26
MY166058A (en) 2018-05-22
HK1201532A1 (zh) 2015-09-04
AU2012285675B2 (en) 2016-03-03
JP5779297B2 (ja) 2015-09-16
ES2563816T3 (es) 2016-03-16
PL2847173T3 (pl) 2016-06-30
EA025950B1 (ru) 2017-02-28
WO2013011155A2 (en) 2013-01-24
CL2014002905A1 (es) 2014-12-12
KR101530506B1 (ko) 2015-06-19
DK2847173T3 (en) 2016-04-04
CN104245679A (zh) 2014-12-24
HUE027384T2 (en) 2016-10-28
JP2015517472A (ja) 2015-06-22
US9045433B2 (en) 2015-06-02
AU2012285675A1 (en) 2014-10-16
NZ700640A (en) 2016-03-31
SG11201405606RA (en) 2014-11-27
TW201408648A (zh) 2014-03-01
WO2013011155A3 (en) 2013-04-04
CN104245679B (zh) 2016-03-02
EP2847173A2 (en) 2015-03-18
CA2866424A1 (en) 2013-01-24
EP2847173B1 (en) 2015-12-30

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