IN2014DN07315A - - Google Patents

Info

Publication number
IN2014DN07315A
IN2014DN07315A IN7315DEN2014A IN2014DN07315A IN 2014DN07315 A IN2014DN07315 A IN 2014DN07315A IN 7315DEN2014 A IN7315DEN2014 A IN 7315DEN2014A IN 2014DN07315 A IN2014DN07315 A IN 2014DN07315A
Authority
IN
India
Prior art keywords
oxazolidine
temporariiy
nalbuphone
methylcyclobutyl
nalbuphine
Prior art date
Application number
Other languages
English (en)
Inventor
Tomas Hudlicky
Arias Mary Ann Endoma
Original Assignee
Univ Brock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brock filed Critical Univ Brock
Publication of IN2014DN07315A publication Critical patent/IN2014DN07315A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN7315DEN2014 2012-02-03 2013-01-30 IN2014DN07315A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261594678P 2012-02-03 2012-02-03
PCT/CA2013/050072 WO2013113120A1 (fr) 2012-02-03 2013-01-30 Procédé de préparation d'analogues morphiniques par l'intermédiaire de la réaction de réactifs organométalliques avec une oxazolidine dérivée de morphinanes

Publications (1)

Publication Number Publication Date
IN2014DN07315A true IN2014DN07315A (fr) 2015-04-24

Family

ID=48904344

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7315DEN2014 IN2014DN07315A (fr) 2012-02-03 2013-01-30

Country Status (9)

Country Link
US (1) US8981098B2 (fr)
EP (1) EP2809674A4 (fr)
JP (1) JP2015506952A (fr)
CN (1) CN104520302A (fr)
AU (1) AU2013214667A1 (fr)
CA (1) CA2863242A1 (fr)
IN (1) IN2014DN07315A (fr)
MX (1) MX2014009353A (fr)
WO (1) WO2013113120A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9701687B2 (en) 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
US9701688B2 (en) 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60152447A (ja) * 1984-01-19 1985-08-10 Toyobo Co Ltd ２−ν，νジ置換アミノ−２−置換−１，３−プロパンジオ−ルの合成法
DE10229842A1 (de) 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
PT1664061T (pt) * 2003-09-22 2017-06-22 Glaxosmithkline Australia Pty Ltd Processo para a síntese de compostos de morfinano e seus intermediários
US20080234306A1 (en) * 2006-11-22 2008-09-25 Progenics Pharmaceuticals, Inc. N-Oxides of 4,5-Epoxy-Morphinanium Analogs
WO2009067275A1 (fr) 2007-11-21 2009-05-28 Progenics Pharmaceuticals, Inc N-oxydes d'analogues 4,5-époxy-morphinanium
EP2344506B1 (fr) * 2008-09-30 2016-02-10 Mallinckrodt LLC Procédés d'alkylation de groupes amine secondaire de dérivés de morphinane
WO2010121369A1 (fr) 2009-04-24 2010-10-28 Brock University Procédés pour la préparation de composés de morphinane et de morphinone
AU2011263417B2 (en) * 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
ES2537610T3 (es) * 2010-06-11 2015-06-10 Rhodes Technologies Proceso para la N-desalquilación de aminas terciarias
CN103596962B (zh) * 2011-05-02 2017-02-15 布鲁克大学 通过使用环化脱水试剂的n‑氧化物的n‑脱甲基化制备吗啡类似物的方法和中间体

Also Published As

Publication number Publication date
CA2863242A1 (fr) 2013-08-08
US20140371458A1 (en) 2014-12-18
JP2015506952A (ja) 2015-03-05
EP2809674A1 (fr) 2014-12-10
US8981098B2 (en) 2015-03-17
CN104520302A (zh) 2015-04-15
AU2013214667A1 (en) 2014-09-25
EP2809674A4 (fr) 2015-09-02
MX2014009353A (es) 2015-11-06
WO2013113120A1 (fr) 2013-08-08

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