IN2014DN06529A - - Google Patents

Download PDF

Info

Publication number
IN2014DN06529A
IN2014DN06529A IN6529DEN2014A IN2014DN06529A IN 2014DN06529 A IN2014DN06529 A IN 2014DN06529A IN 6529DEN2014 A IN6529DEN2014 A IN 6529DEN2014A IN 2014DN06529 A IN2014DN06529 A IN 2014DN06529A
Authority
IN
India
Prior art keywords
methods
pharmaceutical compositions
relates
present
providing
Prior art date
Application number
Inventor
Magnus Brisander
Mustafa Demirbüker
Gérald Jesson
Martin Malmsten
Helene Dérand
Original Assignee
Xspray Microparticles Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xspray Microparticles Ab filed Critical Xspray Microparticles Ab
Publication of IN2014DN06529A publication Critical patent/IN2014DN06529A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Window Of Vehicle (AREA)

Abstract

The present invention relates to the field of methods for providing components of pharmaceutical compositions comprising poorly water soluble drugs. In particular the present invention relates to methods for providing stable amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix forming component useful in pharmaceutical compositions.
IN6529DEN2014 2012-01-13 2013-01-11 IN2014DN06529A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261586187P 2012-01-13 2012-01-13
SE1250015 2012-01-13
US201261713120P 2012-10-12 2012-10-12
SE1251160 2012-10-12
PCT/SE2013/050015 WO2013105894A1 (en) 2012-01-13 2013-01-11 A method for producing stable, amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix- forming component.

Publications (1)

Publication Number Publication Date
IN2014DN06529A true IN2014DN06529A (en) 2015-06-12

Family

ID=48781736

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6529DEN2014 IN2014DN06529A (en) 2012-01-13 2013-01-11

Country Status (15)

Country Link
US (20) US9456992B2 (en)
EP (7) EP4218740A1 (en)
JP (13) JP6238310B2 (en)
CN (4) CN107115317A (en)
AU (8) AU2013208324B2 (en)
CA (2) CA2860973C (en)
DK (2) DK3181122T3 (en)
ES (2) ES2946549T3 (en)
FI (2) FI3181122T3 (en)
HR (2) HRP20230529T1 (en)
IL (4) IL293779B2 (en)
IN (1) IN2014DN06529A (en)
MX (4) MX347456B (en)
PL (3) PL3181128T3 (en)
WO (2) WO2013105895A1 (en)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6238310B2 (en) 2012-01-13 2017-11-29 エックススプレイ ファーマ パブリーク・アクチエボラグＸＳｐｒａｙ Ｐｈａｒｍａ ＡＢ（ｐｕｂｌ） Method for producing stable amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing matrix-forming component
MX371297B (en) * 2012-01-13 2020-01-24 Xspray Microparticles Ab A pharmaceutical composition comprising stable, amorphous hybrid nanopraticles of at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component.
EP2854859A4 (en) 2012-06-04 2016-01-13 Pharmacyclics Inc Crystalline forms of a bruton's tyrosine kinase inhibitor
JP6356678B2 (en) 2012-09-17 2018-07-11 ファイザー・インク Method for producing therapeutic nanoparticles
CN104367557A (en) * 2013-08-12 2015-02-25 浙江九洲药业股份有限公司 Preparation method of amorphous composition composed of drug active component and PVP
GB201400034D0 (en) * 2014-01-02 2014-02-19 Astrazeneca Ab Pharmaceutical Compositions comprising AZD9291
UA121967C2 (en) 2014-03-14 2020-08-25 Пфайзер Інк. Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
WO2015145145A1 (en) * 2014-03-24 2015-10-01 Cipla Limited Pharmaceutical composition comprising lapatinib
ZA201502073B (en) * 2014-03-28 2016-03-30 Cipla Ltd Pharmaceutical composition
US10231937B2 (en) 2014-06-24 2019-03-19 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
PT107846B (en) * 2014-08-01 2019-03-22 Hovione Farm S A Production of Amorphous Solid Dispersion Nanoparticles by Controlled Co-Precipitation
AU2015300798A1 (en) * 2014-08-07 2017-02-02 Pharmacyclics Llc Novel formulations of a Bruton's tyrosine kinase inhibitor
WO2016090240A1 (en) * 2014-12-04 2016-06-09 Astex Pharmaceuticals, Inc. Pharmaceutical compositions for increasing the bioavailability of poorly soluble drugs
WO2016097011A1 (en) * 2014-12-19 2016-06-23 Synthon B.V. Pharmaceutical composition comprising amorphous nilotinib
CA3177990A1 (en) 2015-03-03 2016-09-09 Pharmacyclics Llc Pharmaceutical formulations of a bruton's tyrosine kinase inhibitor
WO2016154240A1 (en) * 2015-03-24 2016-09-29 Dow Global Technologies Llc Aqueous solution of polymers
CZ2015250A3 (en) * 2015-04-14 2016-10-26 Zentiva, K.S. Vemurafenib amorphous forms
EP3393647A4 (en) 2015-12-22 2019-08-21 The Trustees of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
WO2017108605A1 (en) 2015-12-22 2017-06-29 Synthon B.V. Pharmaceutical composition comprising amorphous dasatinib
WO2017158625A1 (en) * 2016-03-17 2017-09-21 Sun Pharmaceutical Industries Ltd. Pharmaceutical composition of nilotinib
JP6739275B2 (en) * 2016-08-02 2020-08-12 日本化薬株式会社 Pharmaceutical composition containing gefitinib as an active ingredient
US11491114B2 (en) * 2016-10-12 2022-11-08 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents
CN110291089B (en) 2017-01-17 2022-05-27 海帕瑞吉尼克斯股份有限公司 Protein kinase inhibitors for promoting liver regeneration or reducing or preventing liver cell death
MA47793A (en) 2017-03-15 2020-01-22 Sun Pharma Advanced Res Co Ltd NEW SOAP DISPERSION OF HYDRAZIDE N'- (2-CHLORO-6-METHYL-BENZOYL) 4-METHYL-3-QUINOLINE-3-YLETHYNYL-BENZOIC ACID
WO2018167803A1 (en) 2017-03-15 2018-09-20 Sun Pharma Advanced Research Company Limited Novel amorphous dispersion of cyclopropanecarboxylic acid (5-{5-[ n'-(2-chloro-6-methylbenzoyl) hydrazinocarbonyl] -2-methyl-phenylethynyl}-pyridin-2-yl) amide
BR112019019649A2 (en) 2017-04-06 2020-04-14 Johnson Matthey Plc hydrated and crystalline form of afatinib dimaleate, pharmaceutical composition, and methods for treating disease in a patient and for producing the z form.
WO2018203636A1 (en) * 2017-05-02 2018-11-08 주식회사 삼양바이오팜 Composition having improved water solubility and bioavailability
KR102082775B1 (en) * 2017-05-02 2020-02-28 주식회사 삼양바이오팜 Formulation with enhanced water solubility and bioavailability
CN107157941B (en) * 2017-05-16 2020-12-25 北京化工大学 Dasatinib nano preparation and preparation method thereof
CN107011262B (en) * 2017-06-01 2019-10-29 中国药科大学 A method of Sorafenib Tosylate polymorphic K particle is prepared based on supercritical anti-solvent technology
WO2019055539A1 (en) * 2017-09-12 2019-03-21 Prudhomme Robert K Cellulosic polymer nanoparticles and methods of forming them
KR102184117B1 (en) * 2017-10-31 2020-11-30 주식회사 삼양바이오팜 Composition of Sorafenib nanoparticles for oral administration with enhanced solubility and bioavailability and method for preparation thereof
KR101922369B1 (en) * 2018-01-12 2018-11-26 한국지질자원연구원 Drug-layered silicate composite for enhanced oral bioavailability, oral pharmacological composition including the drug-layered silicate composite, and method of manufacturing the drug-layered silicate composite
WO2019195827A1 (en) 2018-04-06 2019-10-10 Johnson Matthey Public Limited Company Novel form of ibrutinib
WO2019209908A1 (en) 2018-04-25 2019-10-31 Johnson Matthey Public Limited Company Crystalline forms of dasatinib
CN116808044A (en) 2018-06-15 2023-09-29 汉达癌症医药责任有限公司 Salts of kinase inhibitors and compositions thereof
EP3781568A1 (en) 2018-06-22 2021-02-24 Johnson Matthey Public Limited Company Form of ponatinib
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
CN109833483B (en) * 2018-09-17 2020-10-23 山东大学 Preparation of small molecular chaperone-based sorafenib nano-drug
WO2020072870A1 (en) 2018-10-05 2020-04-09 Johnson Matthey Public Limited Company Co-crystal forms of baricitinib
CN109044977A (en) * 2018-10-26 2018-12-21 武汉工程大学 A kind of pleasure is cut down for Buddhist nun's solid dispersions and preparation method thereof and preparation
WO2020093896A1 (en) * 2018-11-06 2020-05-14 Beijing Innocare Pharma Tech Co., Ltd. Amorphous solid dispersion comprising 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide
WO2020172120A1 (en) * 2019-02-18 2020-08-27 Slayback Pharma Llc Pharmaceutical compositions of nilotinib
US10799459B1 (en) 2019-05-17 2020-10-13 Xspray Microparticles Ab Rapidly disintegrating solid oral dosage forms containing dasatinib
CN110801434A (en) * 2019-10-31 2020-02-18 金华职业技术学院 Method for preparing lapatinib tosylate solid dispersion by freeze-drying method
AU2021210974A1 (en) * 2020-01-24 2022-09-22 Nanocopoeia, Llc Amorphous solid dispersions of dasatinib and uses thereof
JP2023513045A (en) 2020-01-31 2023-03-30 ナノコピーア リミテッド ライアビリティ カンパニー Amorphous nilotinib microparticles and uses thereof
EP3861989A1 (en) * 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Pharmaceutical composition containing regorafenib and a stabilizing agent
CN112294971B (en) * 2020-02-20 2022-02-01 深圳市泰力生物医药有限公司 Nilotinib compositions having improved solubility
CN111358952B (en) * 2020-04-15 2022-03-15 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） Anti-tumor pharmaceutical composition, preparation and application thereof
EP4142699A1 (en) * 2020-04-30 2023-03-08 Nanocopoeia LLC Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib
CN111467501B (en) * 2020-05-22 2021-06-15 深圳市泰力生物医药有限公司 Compositions with improved dissolution properties
CN111973596B (en) * 2020-06-15 2022-02-15 深圳市泰力生物医药有限公司 Anti-pulmonary fibrosis composition with improved dissolution property
BR112023000501A2 (en) * 2020-07-23 2023-01-31 Crititech Inc LAPATINIB PARTICLES AND USES THEREOF
WO2022034914A1 (en) * 2020-08-13 2022-02-17 カルナバイオサイエンス株式会社 Readily-soluble solid pharmaceutical preparation and production method for same
JP2023544998A (en) 2020-10-02 2023-10-26 ロンザ・ベンド・インコーポレーテッド Acetic acid as a processing aid in the spray drying of basic drugs
US20230310393A1 (en) * 2020-12-07 2023-10-05 Tianjin Creatron Biotechnology Co., Ltd. Sorafenib pharmaceutical composition with high bioavailability and use thereof
EP4281047A1 (en) 2021-01-21 2023-11-29 XSpray Pharma AB (publ) Fast dissolving pharmaceutical compositions of dasatinib
US11980619B2 (en) 2021-07-28 2024-05-14 Nanocopoeia, Llc Pharmaceutical compositions and crushable tablets including amorphous solid dispersions of dasatinib and uses
WO2023006029A1 (en) * 2021-07-30 2023-02-02 上海博志研新药物技术有限公司 Pazopanib oral pharmaceutical composition, and preparation method therefor and use thereof
KR20230114478A (en) * 2022-01-25 2023-08-01 (주)피알지에스앤텍 Granule comprising Progerinin, and sachet using the granule
WO2023155182A1 (en) 2022-02-21 2023-08-24 北京睿创康泰医药研究院有限公司 Low-dose, high-exposure sorafenib or donafenib oral formulation and use thereof
WO2024080308A1 (en) * 2022-10-12 2024-04-18 中外製薬株式会社 Composition containing peptide, surfactant, and polymer
CN116688139B (en) * 2023-06-25 2024-03-29 深圳市新阳唯康科技有限公司 Crizotinib pharmaceutical composition, and preparation method and application thereof
CN117100715A (en) * 2023-09-05 2023-11-24 深圳市泰力生物医药有限公司 Capsule containing amorphous nilotinib and preparation method thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
US6406781B1 (en) * 1998-06-23 2002-06-18 3M Innovative Properties Company Stretch release adhesive article with stabilizer
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
GB9925934D0 (en) * 1999-11-03 1999-12-29 Glaxo Group Ltd Novel apparatus and process
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
SE0303476D0 (en) 2003-12-22 2003-12-22 Censdelivery Ab Device, method and use for the formation of small particles
US7625911B2 (en) * 2005-01-12 2009-12-01 Mai De Ltd. Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
WO2006123223A1 (en) 2005-05-19 2006-11-23 Pfizer Inc. Pharmaceutical compostions comprising an amorphous form of a vegf-r inhibitor
DE102005053066A1 (en) 2005-11-04 2007-05-10 Basf Ag Use of copolymers as solubilizers for sparingly water-soluble compounds
WO2007133750A2 (en) * 2006-05-12 2007-11-22 The Board Of Trustees Of The Leland Stanford Junior University Encapsulated nanoparticles for drug delivery
EP2043606A2 (en) * 2006-06-13 2009-04-08 Elan Pharma International Limited Nanoparticulate kinase inhibitor formulations
CA2657379A1 (en) * 2006-07-10 2008-01-17 Elan Pharma International Ltd. Nanoparticulate sorafenib formulations
EP1920767A1 (en) 2006-11-09 2008-05-14 Abbott GmbH & Co. KG Melt-processed imatinib dosage form
CA2667720A1 (en) * 2006-11-09 2008-05-15 Abbott Gmbh & Co. Kg. Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor
MX2009010761A (en) 2007-04-05 2009-10-28 Pfizer Prod Inc Crystalline forms of 6- [2- (methylcarbamoyl) phenylsulfanyl] -3-e- [2- (pyridin-2-yl) ethenyl] indazole suitable for the treatment of abnormal cell growth in mammals.
US7823700B2 (en) * 2007-07-20 2010-11-02 International Business Machines Corporation User identification enabled elevator control method and system
US8585943B2 (en) 2007-12-07 2013-11-19 Xspray Microparticles Ab Method and arrangement for the production of particles
JP2009155282A (en) * 2007-12-27 2009-07-16 Kowa Co Solid dispersion-containing pharmaceutical composition
WO2009100176A2 (en) * 2008-02-07 2009-08-13 Abbott Laboratories Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor
EP2105130A1 (en) 2008-03-25 2009-09-30 Ratiopharm GmbH Pharmaceutical formula and method for its production
GB0909154D0 (en) * 2008-09-25 2009-07-08 Nanomaterials Tech Pte Ltd A process for making particles for delivery of drug nanoparticles
US9050317B2 (en) * 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
CZ20098A3 (en) * 2009-01-13 2010-07-21 Zentiva, K.S. Medicinal forms of tyrosine kinase inhibitors
US8603521B2 (en) * 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
KR100924236B1 (en) * 2009-06-23 2009-10-29 충남대학교산학협력단 Methods and apparatus for preparing ultra-fine particles with narrow particle size distribution
US20130093111A1 (en) 2010-06-14 2013-04-18 Xspray Microparticles Ab Apparatus and Method for the Production of Particles
JP6238310B2 (en) * 2012-01-13 2017-11-29 エックススプレイ ファーマ パブリーク・アクチエボラグＸＳｐｒａｙ Ｐｈａｒｍａ ＡＢ（ｐｕｂｌ） Method for producing stable amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing matrix-forming component
JP2017141910A (en) * 2016-02-10 2017-08-17 武蔵精密工業株式会社 Transmission device
JP6688624B2 (en) * 2016-02-11 2020-04-28 学校法人 名城大学 Gas tank and gas storage and supply facility including a plurality of gas tanks
JP6767610B2 (en) * 2016-02-12 2020-10-14 パナソニックＩｐマネジメント株式会社 Insulation and its manufacturing method

Also Published As

Publication number Publication date
US20210093616A1 (en) 2021-04-01
US20190275018A1 (en) 2019-09-12
EP3181127A1 (en) 2017-06-21
US20170143715A1 (en) 2017-05-25
US10555937B2 (en) 2020-02-11
IL293779B2 (en) 2023-09-01
US20180042906A1 (en) 2018-02-15
AU2018200931A1 (en) 2018-03-01
US9827230B2 (en) 2017-11-28
JP6463416B2 (en) 2019-02-06
ES2946549T3 (en) 2023-07-20
JP6628834B2 (en) 2020-01-15
IL293775B2 (en) 2023-05-01
AU2019275513B2 (en) 2022-03-10
CA2860973C (en) 2021-10-26
US11241419B2 (en) 2022-02-08
MX347456B (en) 2017-04-27
US11426391B2 (en) 2022-08-30
EP4218740A1 (en) 2023-08-02
JP2019070000A (en) 2019-05-09
US20220160687A1 (en) 2022-05-26
AU2018200933B2 (en) 2020-01-02
US20190255029A1 (en) 2019-08-22
JP2017222694A (en) 2017-12-21
EP2802314A1 (en) 2014-11-19
US10561644B2 (en) 2020-02-18
US10772877B2 (en) 2020-09-15
IL233583B (en) 2020-10-29
US20220168285A1 (en) 2022-06-02
JP2015503613A (en) 2015-02-02
IL293779A (en) 2022-08-01
US10143683B2 (en) 2018-12-04
PL2802314T3 (en) 2021-06-14
US20220117947A1 (en) 2022-04-21
US9456992B2 (en) 2016-10-04
IL233583A0 (en) 2014-08-31
EP3181127B1 (en) 2023-03-08
MX2023008180A (en) 2023-08-03
CN104159574A (en) 2014-11-19
HRP20230510T1 (en) 2023-10-27
US11376243B2 (en) 2022-07-05
CN107115317A (en) 2017-09-01
JP6238311B2 (en) 2017-11-29
IL233582B (en) 2021-09-30
JP6463418B2 (en) 2019-02-06
US11517562B2 (en) 2022-12-06
US20190282553A1 (en) 2019-09-19
AU2018200928A1 (en) 2018-03-01
ES2946735T3 (en) 2023-07-25
JP2018172393A (en) 2018-11-08
JP2021073228A (en) 2021-05-13
US20190076413A1 (en) 2019-03-14
WO2013105894A1 (en) 2013-07-18
JP6463417B2 (en) 2019-02-06
US10561645B2 (en) 2020-02-18
JP2017222695A (en) 2017-12-21
MX2022003458A (en) 2022-06-02
AU2018200933A1 (en) 2018-03-01
EP3181122A1 (en) 2017-06-21
CN107115318A (en) 2017-09-01
MX2020000984A (en) 2020-07-13
EP2802316A4 (en) 2015-11-18
EP3181128B1 (en) 2023-03-08
FI3181122T3 (en) 2023-05-31
MX2014008457A (en) 2015-02-12
AU2013208323A1 (en) 2014-07-24
US9833443B2 (en) 2017-12-05
AU2013208323B2 (en) 2017-07-06
JP6463419B2 (en) 2019-02-06
US20190275019A1 (en) 2019-09-12
JP6351811B2 (en) 2018-07-04
CA2860932C (en) 2021-02-16
US20170143683A1 (en) 2017-05-25
DK3181128T3 (en) 2023-06-06
US20140356443A1 (en) 2014-12-04
EP3766486A1 (en) 2021-01-20
PL3181122T3 (en) 2023-07-31
US20160361313A1 (en) 2016-12-15
EP2802316A1 (en) 2014-11-19
IL293779B1 (en) 2023-05-01
JP2018035147A (en) 2018-03-08
JP6351810B2 (en) 2018-07-04
HRP20230529T1 (en) 2023-09-15
JP6238310B2 (en) 2017-11-29
AU2021269328A1 (en) 2021-12-09
EP3181128A1 (en) 2017-06-21
US10561643B2 (en) 2020-02-18
EP2802314A4 (en) 2015-08-12
JP2018012714A (en) 2018-01-25
DK3181122T3 (en) 2023-06-06
JP7006995B2 (en) 2022-01-24
US9833442B2 (en) 2017-12-05
US11963951B2 (en) 2024-04-23
EP2802314B1 (en) 2020-11-25
WO2013105895A1 (en) 2013-07-18
CA2860973A1 (en) 2013-07-18
AU2013208324A1 (en) 2014-07-24
US20240189290A1 (en) 2024-06-13
IL293775B1 (en) 2023-01-01
CN104159577B (en) 2017-03-15
JP2018008973A (en) 2018-01-18
US10314829B2 (en) 2019-06-11
IL293775A (en) 2022-08-01
JP2018012713A (en) 2018-01-25
JP7391507B2 (en) 2023-12-05
CN104159577A (en) 2014-11-19
JP2017222693A (en) 2017-12-21
AU2018200931B2 (en) 2019-07-18
JP2023123773A (en) 2023-09-05
JP6351809B2 (en) 2018-07-04
PL3181128T3 (en) 2023-07-31
US20190060294A1 (en) 2019-02-28
AU2018200928B2 (en) 2019-07-18
JP2015503612A (en) 2015-02-02
EP3181122B1 (en) 2023-03-08
CA2860932A1 (en) 2013-07-18
US20140378454A1 (en) 2014-12-25
US20160250153A1 (en) 2016-09-01
FI3181128T3 (en) 2023-06-02
AU2019275513A1 (en) 2019-12-19
US10314830B2 (en) 2019-06-11
AU2021269331A1 (en) 2021-12-09
US20220296575A1 (en) 2022-09-22
US20200253941A1 (en) 2020-08-13
IL233582A0 (en) 2014-08-31
AU2013208324B2 (en) 2017-11-23

Similar Documents

Publication Publication Date Title
IN2014DN06529A (en)
IN2015KN00005A (en)
SG194469A1 (en) Tetrahydroquinoline derivatives useful as bromodomain inhibitors
IN2014MN01736A (en)
TN2013000310A1 (en) Effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections
MX2020005181A (en) Aminopyridine derivatives as tam family kinase inhibitors.
IL231591A0 (en) Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases.
MX2021001231A (en) Heterocyclic compounds and their uses.
IN2014DN10386A (en)
IL237321A0 (en) Ddr2 inhibitors and pharmaceutical compositions containing them
PH12015501096A1 (en) Composition for immediate and extended release
MX361349B (en) Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions.
MX2015012416A (en) Heterocyclic compounds and their uses.
IL285017A (en) A pharmaceutical composition comprising stable, amorphous hybrid nanopraticles of at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component
IN2013MU03641A (en)
CY1118198T1 (en) PANTOTHENIC PRODUCTS FOR TREATMENT OF NEUROLOGICAL DISORDERS
EP2874987A4 (en) alpha-AND gamma-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
MX2014006201A (en) Imatinib solid dosage forms reconstituted just before use.