IN2014DN03077A - - Google Patents

Info

Publication number
IN2014DN03077A
IN2014DN03077A IN3077DEN2014A IN2014DN03077A IN 2014DN03077 A IN2014DN03077 A IN 2014DN03077A IN 3077DEN2014 A IN3077DEN2014 A IN 3077DEN2014A IN 2014DN03077 A IN2014DN03077 A IN 2014DN03077A
Authority
IN
India
Prior art keywords
sirt2
methods
assay
practicing
kits
Prior art date
Application number
Other languages
English (en)
Inventor
Hening Lin
Bin He
Original Assignee
Univ Cornell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cornell filed Critical Univ Cornell
Publication of IN2014DN03077A publication Critical patent/IN2014DN03077A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/38Amides of thiocarboxylic acids
    • C07C327/40Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/42Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IN3077DEN2014 2011-10-07 2012-10-05 IN2014DN03077A (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161544452P 2011-10-07 2011-10-07
PCT/US2012/058846 WO2013052727A1 (en) 2011-10-07 2012-10-05 Methods of treatment using modulators of sirt2

Publications (1)

Publication Number Publication Date
IN2014DN03077A true IN2014DN03077A (enExample) 2015-05-15

Family

ID=48044173

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3077DEN2014 IN2014DN03077A (enExample) 2011-10-07 2012-10-05

Country Status (6)

Country Link
US (2) US9359293B2 (enExample)
EP (1) EP2763962B1 (enExample)
CN (2) CN103974934B (enExample)
ES (1) ES2773266T3 (enExample)
IN (1) IN2014DN03077A (enExample)
WO (1) WO2013052727A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2763962B1 (en) * 2011-10-07 2019-12-04 Cornell University Methods of treatment using modulators of sirt2
WO2014149196A1 (en) * 2013-03-22 2014-09-25 University Of Florida Research Foundation, Inc. Polymer nanocomposites for early diagnosis of diseases
WO2014197775A1 (en) * 2013-06-06 2014-12-11 Cornell University Thiourea compounds and their use as inhibitors of sirt2 or sirt5
JP2020506707A (ja) * 2017-02-03 2020-03-05 ザ マクリーン ホスピタル コーポレーション 細胞の運命を操作するための方法
CN110551048B (zh) * 2018-06-04 2021-08-10 中国科学院上海药物研究所 一类sirt2抑制剂、其制备方法及用途
US12161639B2 (en) 2018-07-17 2024-12-10 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating PACS1 and PACS2 syndromes
CN114315670B (zh) * 2022-01-19 2024-03-29 贵州医科大学 一种sirt2/hdac6双靶标抑制剂及其应用
CN116178340B (zh) * 2023-04-28 2023-08-18 细胞生态海河实验室 一种protac化合物、制备方法及药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10063008A1 (de) 2000-12-16 2002-06-20 Merck Patent Gmbh Carbonsäureamidderivate
MXPA06007059A (es) * 2003-12-22 2006-08-23 Astellas Pharma Inc Derivados de ornitina como agonistas o antagonistas de prostaglandina e2.
US20070021434A1 (en) * 2005-06-24 2007-01-25 Migenix Inc. Non-nucleoside anti-hepacivirus agents and uses thereof
WO2008080223A1 (en) * 2006-12-28 2008-07-10 Migenix Inc. Compositions and methods for treating hyperproliferative disease
EP2763962B1 (en) * 2011-10-07 2019-12-04 Cornell University Methods of treatment using modulators of sirt2

Also Published As

Publication number Publication date
US9359293B2 (en) 2016-06-07
EP2763962A1 (en) 2014-08-13
CN103974934A (zh) 2014-08-06
US20140249216A1 (en) 2014-09-04
US20160279091A1 (en) 2016-09-29
EP2763962A4 (en) 2015-08-19
CN103974934B (zh) 2019-07-23
EP2763962B1 (en) 2019-12-04
CN110143900B (zh) 2021-08-03
WO2013052727A1 (en) 2013-04-11
ES2773266T3 (es) 2020-07-10
US9572789B2 (en) 2017-02-21
CN110143900A (zh) 2019-08-20

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