IN2014DN03077A - - Google Patents
Info
- Publication number
- IN2014DN03077A IN2014DN03077A IN3077DEN2014A IN2014DN03077A IN 2014DN03077 A IN2014DN03077 A IN 2014DN03077A IN 3077DEN2014 A IN3077DEN2014 A IN 3077DEN2014A IN 2014DN03077 A IN2014DN03077 A IN 2014DN03077A
- Authority
- IN
- India
- Prior art keywords
- sirt2
- methods
- assay
- practicing
- kits
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
Abstract
The instant application describes novel compounds that modulate (in particular inhibit) Sirt2 with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof methods of treatment (i.e. cancer and neurodegenerative disease) by administration of the modulating compounds assay methods for finding modulators of Sirt2 and kits for practicing the assay method.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161544452P | 2011-10-07 | 2011-10-07 | |
PCT/US2012/058846 WO2013052727A1 (en) | 2011-10-07 | 2012-10-05 | Methods of treatment using modulators of sirt2 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN03077A true IN2014DN03077A (en) | 2015-05-15 |
Family
ID=48044173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN3077DEN2014 IN2014DN03077A (en) | 2011-10-07 | 2012-10-05 |
Country Status (6)
Country | Link |
---|---|
US (2) | US9359293B2 (en) |
EP (1) | EP2763962B1 (en) |
CN (2) | CN110143900B (en) |
ES (1) | ES2773266T3 (en) |
IN (1) | IN2014DN03077A (en) |
WO (1) | WO2013052727A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN2014DN03077A (en) * | 2011-10-07 | 2015-05-15 | Univ Cornell | |
US9945865B2 (en) * | 2013-03-22 | 2018-04-17 | University Of Florida Research Foundation, Inc. | Polymer nanocomposites for early diagnosis of diseases |
US10556878B2 (en) * | 2013-06-06 | 2020-02-11 | Cornell University | Thiourea compounds and their use as inhibitors of Sirt2 or Sirt5 |
WO2018144864A1 (en) * | 2017-02-03 | 2018-08-09 | The Mclean Hospital Corporation | Methods for manipulating cell fate |
CN110551048B (en) * | 2018-06-04 | 2021-08-10 | 中国科学院上海药物研究所 | SIRT2 inhibitor, preparation method and application thereof |
CN114315670B (en) * | 2022-01-19 | 2024-03-29 | 贵州医科大学 | SIRT2/HDAC6 double-target inhibitor and application thereof |
CN116178340B (en) * | 2023-04-28 | 2023-08-18 | 细胞生态海河实验室 | PROTAC compound, preparation method and pharmaceutical composition |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10063008A1 (en) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | carboxamide |
WO2005061475A2 (en) | 2003-12-22 | 2005-07-07 | Astellas Pharma Inc. | Ornithine derivatives as prostaglandin e2 agonists or antagonists |
WO2007002639A2 (en) | 2005-06-24 | 2007-01-04 | Migenix Inc. | Non-nucleoside anti-hepacivirus agents and uses thereof |
WO2008080223A1 (en) | 2006-12-28 | 2008-07-10 | Migenix Inc. | Compositions and methods for treating hyperproliferative disease |
IN2014DN03077A (en) * | 2011-10-07 | 2015-05-15 | Univ Cornell |
-
2012
- 2012-10-05 IN IN3077DEN2014 patent/IN2014DN03077A/en unknown
- 2012-10-05 EP EP12838058.1A patent/EP2763962B1/en active Active
- 2012-10-05 US US14/349,140 patent/US9359293B2/en active Active
- 2012-10-05 CN CN201910002021.XA patent/CN110143900B/en active Active
- 2012-10-05 ES ES12838058T patent/ES2773266T3/en active Active
- 2012-10-05 CN CN201280059788.2A patent/CN103974934B/en active Active
- 2012-10-05 WO PCT/US2012/058846 patent/WO2013052727A1/en active Application Filing
-
2016
- 2016-06-03 US US15/172,756 patent/US9572789B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2763962A4 (en) | 2015-08-19 |
US9572789B2 (en) | 2017-02-21 |
CN103974934B (en) | 2019-07-23 |
CN110143900A (en) | 2019-08-20 |
CN103974934A (en) | 2014-08-06 |
CN110143900B (en) | 2021-08-03 |
WO2013052727A1 (en) | 2013-04-11 |
ES2773266T3 (en) | 2020-07-10 |
EP2763962A1 (en) | 2014-08-13 |
US20140249216A1 (en) | 2014-09-04 |
US9359293B2 (en) | 2016-06-07 |
EP2763962B1 (en) | 2019-12-04 |
US20160279091A1 (en) | 2016-09-29 |
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