IN2014DN00145A - - Google Patents
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- Publication number
- IN2014DN00145A IN2014DN00145A IN145DEN2014A IN2014DN00145A IN 2014DN00145 A IN2014DN00145 A IN 2014DN00145A IN 145DEN2014 A IN145DEN2014 A IN 145DEN2014A IN 2014DN00145 A IN2014DN00145 A IN 2014DN00145A
- Authority
- IN
- India
- Prior art keywords
- solid forms
- amide
- pharmaceutical compositions
- present
- relates
- Prior art date
Links
- 239000007787 solid Substances 0.000 abstract 4
- 150000001408 amides Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
- -1 dimethyl ethyl Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161499222P | 2011-06-21 | 2011-06-21 | |
| PCT/EP2012/061756 WO2012175522A1 (en) | 2011-06-21 | 2012-06-19 | Polymorphs of (s)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN00145A true IN2014DN00145A (https=) | 2015-05-22 |
Family
ID=46319784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN145DEN2014 IN2014DN00145A (https=) | 2011-06-21 | 2012-06-19 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9006270B2 (https=) |
| EP (1) | EP2723733A1 (https=) |
| JP (1) | JP2014517049A (https=) |
| KR (1) | KR20140033432A (https=) |
| CN (1) | CN103619840B (https=) |
| BR (1) | BR112013032687A2 (https=) |
| CA (1) | CA2839621A1 (https=) |
| IN (1) | IN2014DN00145A (https=) |
| MX (1) | MX2013014887A (https=) |
| RU (1) | RU2014101626A (https=) |
| WO (1) | WO2012175522A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011066352A1 (en) | 2009-11-27 | 2011-06-03 | Genzyme Corporation | An amorphous and a crystalline form of genz 112638 hemitartrat as inhibitor of glucosylceramide synthase |
| WO2013148912A1 (en) * | 2012-03-30 | 2013-10-03 | Novartis Ag | Compounds for use in the treatment of neuroblastoma, ewing's sarcoma or rhabdomyosarcoma |
| SI3076969T1 (sl) * | 2013-12-06 | 2021-12-31 | Novartis Ag | Režim omderjanja izooblike alfa selektivnega zaviralca fosfatidilino- zitol 3-kinaze |
| RU2690685C2 (ru) * | 2014-10-03 | 2019-06-05 | Новартис Аг | Фармацевтические композиции, содержащие алпелисиб |
| NZ780966A (en) | 2019-04-18 | 2026-02-27 | Univ Johns Hopkins | Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a] pyridine derivatives and use thereof |
| CN112961090A (zh) * | 2019-12-13 | 2021-06-15 | 武汉九州钰民医药科技有限公司 | 合成Alpelisib的关键中间体及其制备方法 |
| CN111057051A (zh) * | 2019-12-16 | 2020-04-24 | 武汉九州钰民医药科技有限公司 | PI3K抑制剂Alpelisib的新合成方法 |
| CN110964005A (zh) * | 2019-12-16 | 2020-04-07 | 武汉九州钰民医药科技有限公司 | 一种Alpelisib的制备工艺 |
| JP7649637B2 (ja) | 2020-10-06 | 2025-03-21 | エルジー ディスプレイ カンパニー リミテッド | 伝送装置及び表示システム |
| JP2024516006A (ja) * | 2021-05-03 | 2024-04-11 | ノバルティス アーゲー | アルペリシブ製剤 |
| CN116925023B (zh) * | 2023-07-18 | 2025-11-21 | 江苏桐孚高新材料有限公司 | 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY29149A1 (es) * | 2004-10-07 | 2006-05-31 | Boehringer Ingelheim Int | Tiazolil-dihidro-indazoles |
| EP2016075A1 (en) * | 2006-05-03 | 2009-01-21 | AstraZeneca AB | Thiazole derivatives and their use as anti-tumour agents |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| AR082418A1 (es) * | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
-
2012
- 2012-06-19 US US14/127,027 patent/US9006270B2/en not_active Expired - Fee Related
- 2012-06-19 MX MX2013014887A patent/MX2013014887A/es not_active Application Discontinuation
- 2012-06-19 CN CN201280030432.6A patent/CN103619840B/zh not_active Expired - Fee Related
- 2012-06-19 EP EP12728285.3A patent/EP2723733A1/en not_active Withdrawn
- 2012-06-19 KR KR1020137033590A patent/KR20140033432A/ko not_active Withdrawn
- 2012-06-19 JP JP2014516316A patent/JP2014517049A/ja active Pending
- 2012-06-19 CA CA2839621A patent/CA2839621A1/en not_active Abandoned
- 2012-06-19 WO PCT/EP2012/061756 patent/WO2012175522A1/en not_active Ceased
- 2012-06-19 BR BR112013032687A patent/BR112013032687A2/pt not_active IP Right Cessation
- 2012-06-19 IN IN145DEN2014 patent/IN2014DN00145A/en unknown
- 2012-06-19 RU RU2014101626/04A patent/RU2014101626A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140033432A (ko) | 2014-03-18 |
| CN103619840A (zh) | 2014-03-05 |
| AU2012274141B2 (en) | 2015-12-24 |
| JP2014517049A (ja) | 2014-07-17 |
| US9006270B2 (en) | 2015-04-14 |
| WO2012175522A1 (en) | 2012-12-27 |
| CN103619840B (zh) | 2016-01-20 |
| BR112013032687A2 (pt) | 2016-08-30 |
| CA2839621A1 (en) | 2012-12-27 |
| US20140171470A1 (en) | 2014-06-19 |
| EP2723733A1 (en) | 2014-04-30 |
| RU2014101626A (ru) | 2015-07-27 |
| AU2012274141A1 (en) | 2013-12-12 |
| MX2013014887A (es) | 2014-02-17 |
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