IN2014DN00101A - - Google Patents
Info
- Publication number
- IN2014DN00101A IN2014DN00101A IN101DEN2014A IN2014DN00101A IN 2014DN00101 A IN2014DN00101 A IN 2014DN00101A IN 101DEN2014 A IN101DEN2014 A IN 101DEN2014A IN 2014DN00101 A IN2014DN00101 A IN 2014DN00101A
- Authority
- IN
- India
- Prior art keywords
- dendrimer
- macromolecules
- pharmaceutically active
- active agent
- surface amino
- Prior art date
Links
- 229920002521 macromolecule Polymers 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 239000000412 dendrimer Substances 0.000 abstract 2
- 229920000736 dendritic polymer Polymers 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/40—Polyamides containing oxygen in the form of ether groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
- C08G83/003—Dendrimers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Bipolar Transistors (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161493886P | 2011-06-06 | 2011-06-06 | |
PCT/AU2012/000647 WO2012167309A1 (en) | 2011-06-06 | 2012-06-06 | Macromolecules |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN00101A true IN2014DN00101A (US06262066-20010717-C00315.png) | 2015-05-15 |
Family
ID=47295262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN101DEN2014 IN2014DN00101A (US06262066-20010717-C00315.png) | 2011-06-06 | 2012-06-06 |
Country Status (19)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117164357A (zh) * | 2023-01-03 | 2023-12-05 | 广东捷成科创电子股份有限公司 | 一种五元系大功率型压电陶瓷材料及其制备方法 |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180326081A1 (en) * | 2011-06-06 | 2018-11-15 | Starpharma Pty Ltd | Macromolecules |
WO2014184503A1 (fr) * | 2013-05-16 | 2014-11-20 | Universite De Strasbourg | Composés dendritiques comprenant un agent chélatant, fluorochrome ou agent de reconnaissance, compositions les comprenant et leurs utilisations |
US20160220689A1 (en) * | 2013-09-10 | 2016-08-04 | Starpharma Pty Ltd. | Macromolecules of dendrimer-platinum conjugates |
EP3152248B1 (en) | 2014-06-06 | 2019-10-09 | Starpharma Pty Ltd | Dendrimer-drug conjugates |
CN112263683A (zh) | 2015-08-11 | 2021-01-26 | 同宜医药(苏州)有限公司 | 多配体药物偶联体及其用途 |
CN106554330B (zh) * | 2015-09-26 | 2019-07-05 | 南京友怡医药科技有限公司 | 水溶性多西他赛抗癌药物化合物及其制备方法和应用 |
CN106554329B (zh) * | 2015-09-26 | 2019-07-05 | 南京友怡医药科技有限公司 | 水溶性紫杉醇抗癌药物化合物及其制备方法和应用 |
WO2017068051A1 (en) * | 2015-10-21 | 2017-04-27 | Lek Pharmaceuticals D.D. | Peg-based dendron and process for producing the same |
WO2017135893A1 (en) * | 2016-02-05 | 2017-08-10 | Nipsea Technologies Pte Ltd | Aqueous dendritic amine coatings |
WO2017196986A1 (en) * | 2016-05-10 | 2017-11-16 | Massachusetts Institute Of Technology | Dendrimer-drug conjugates, hydrogel compositions, and methods |
JOP20190191A1 (ar) * | 2017-02-22 | 2019-08-08 | Astrazeneca Ab | وحدات شجرية علاجية |
KR102668425B1 (ko) * | 2018-03-29 | 2024-05-29 | 니치유 가부시키가이샤 | 분해성 폴리에틸렌글리콜 결합체 |
US12071517B2 (en) | 2018-07-19 | 2024-08-27 | Starpharma Pty Ltd. | Therapeutic dendrimer |
MX2021000677A (es) * | 2018-07-19 | 2021-03-25 | Starpharma Pty Ltd | Dendrimero terapeutico. |
TWI831817B (zh) * | 2018-08-17 | 2024-02-11 | 瑞典商阿斯特捷利康公司 | 治療癌症之方法 |
TW202021575A (zh) * | 2018-08-17 | 2020-06-16 | 瑞典商阿斯特捷利康公司 | 樹枝狀體配製物 |
EP3883934A4 (en) * | 2018-11-20 | 2023-01-11 | Starpharma Pty Limited | THERAPEUTIC DENDRIMETER |
KR20210098449A (ko) * | 2018-11-29 | 2021-08-10 | 스타파마 피티와이 리미티드 | 요법 및 영상화를 위한 덴드리머 |
KR20220052960A (ko) * | 2019-08-28 | 2022-04-28 | 스타파마 피티와이 리미티드 | 표적화된 덴드리머 접합체 |
CA3152111A1 (en) * | 2019-09-26 | 2021-04-01 | David James Owen | Therapeutic dendrimer |
WO2021213492A1 (zh) * | 2020-04-24 | 2021-10-28 | 上海森辉医药有限公司 | 一类载药的大分子及其制备方法 |
CA3180877A1 (en) * | 2020-06-03 | 2021-12-09 | Starpharma Pty Ltd | Therapeutic conjugates |
WO2022042583A1 (zh) | 2020-08-25 | 2022-03-03 | 上海森辉医药有限公司 | 载药的大分子及其制备方法 |
WO2022040761A1 (en) * | 2020-08-31 | 2022-03-03 | Starpharma Pty Ltd | Dendrimer-drug conjugate |
EP4216929A1 (en) * | 2020-09-24 | 2023-08-02 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent |
US11291627B1 (en) * | 2020-09-24 | 2022-04-05 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US7261875B2 (en) * | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
CN101102787A (zh) * | 2004-08-09 | 2008-01-09 | 艾丽奥斯生物制药有限公司 | 合成的超糖基化、抗蛋白酶的多肽变体、口服制剂及其使用方法 |
CN101002945B (zh) * | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
JP5989294B2 (ja) | 2006-01-20 | 2016-09-07 | スターファーマ・プロプライエタリー・リミテッドStarpharma Pty Ltd | 修飾高分子 |
EP2052011B1 (en) * | 2006-08-11 | 2020-11-04 | Starpharma Pty Limited | Targeted polylysine dendrimer therapeutic agent |
ES2672526T3 (es) | 2008-06-26 | 2018-06-14 | Prolynx Llc | Profármacos y conjugados de fármaco-macromolécula que presentan velocidades de liberación de fármaco controladas |
WO2011072290A2 (en) * | 2009-12-11 | 2011-06-16 | The Regents Of The University Of Michigan | Targeted dendrimer-drug conjugates |
CN103025165B (zh) | 2010-05-05 | 2016-06-08 | 普罗林科斯有限责任公司 | 自大分子共轭物的控释 |
WO2011140376A1 (en) | 2010-05-05 | 2011-11-10 | Prolynx Llc | Controlled drug release from dendrimers |
CN103025164B (zh) | 2010-05-05 | 2017-03-08 | 普罗林科斯有限责任公司 | 从固体支撑物中药物的控制释放 |
-
2012
- 2012-06-06 DK DK12797060.6T patent/DK2729179T3/da active
- 2012-06-06 BR BR112013031556-3A patent/BR112013031556B1/pt active IP Right Grant
- 2012-06-06 CN CN201280038437.3A patent/CN103796684B/zh active Active
- 2012-06-06 IN IN101DEN2014 patent/IN2014DN00101A/en unknown
- 2012-06-06 PL PL12797060T patent/PL2729179T3/pl unknown
- 2012-06-06 SI SI201231865T patent/SI2729179T1/sl unknown
- 2012-06-06 WO PCT/AU2012/000647 patent/WO2012167309A1/en active Application Filing
- 2012-06-06 CA CA2837979A patent/CA2837979C/en active Active
- 2012-06-06 KR KR1020147000115A patent/KR101941318B1/ko active IP Right Grant
- 2012-06-06 AU AU2012267200A patent/AU2012267200B2/en active Active
- 2012-06-06 EP EP12797060.6A patent/EP2729179B1/en active Active
- 2012-06-06 CN CN201910456157.8A patent/CN110124051B/zh active Active
- 2012-06-06 LT LTEP12797060.6T patent/LT2729179T/lt unknown
- 2012-06-06 HU HUE12797060A patent/HUE052285T2/hu unknown
- 2012-06-06 PT PT127970606T patent/PT2729179T/pt unknown
- 2012-06-06 ES ES12797060T patent/ES2834992T3/es active Active
- 2012-06-06 JP JP2014513858A patent/JP6158177B2/ja active Active
- 2012-06-06 US US14/124,651 patent/US9744246B2/en active Active
-
2014
- 2014-11-14 HK HK14111566A patent/HK1198356A1/xx unknown
-
2017
- 2017-08-28 US US15/688,780 patent/US10265409B2/en active Active
-
2020
- 2020-12-14 HR HRP20201998TT patent/HRP20201998T1/hr unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117164357A (zh) * | 2023-01-03 | 2023-12-05 | 广东捷成科创电子股份有限公司 | 一种五元系大功率型压电陶瓷材料及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
HUE052285T2 (hu) | 2021-04-28 |
US9744246B2 (en) | 2017-08-29 |
CN103796684A (zh) | 2014-05-14 |
BR112013031556A2 (US06262066-20010717-C00315.png) | 2017-08-29 |
AU2012267200A1 (en) | 2013-05-09 |
US20170354739A1 (en) | 2017-12-14 |
KR101941318B1 (ko) | 2019-01-22 |
CA2837979A1 (en) | 2012-12-13 |
JP6158177B2 (ja) | 2017-07-05 |
US10265409B2 (en) | 2019-04-23 |
WO2012167309A1 (en) | 2012-12-13 |
SI2729179T1 (sl) | 2021-01-29 |
JP2014520105A (ja) | 2014-08-21 |
EP2729179B1 (en) | 2020-09-23 |
EP2729179A4 (en) | 2015-01-28 |
CN110124051A (zh) | 2019-08-16 |
BR112013031556B1 (pt) | 2022-03-29 |
LT2729179T (lt) | 2020-12-28 |
HK1198356A1 (en) | 2015-04-10 |
PL2729179T3 (pl) | 2021-07-19 |
AU2012267200B2 (en) | 2016-02-25 |
PT2729179T (pt) | 2020-11-25 |
CN103796684B (zh) | 2019-06-25 |
CN110124051B (zh) | 2022-10-21 |
ES2834992T3 (es) | 2021-06-21 |
EP2729179A1 (en) | 2014-05-14 |
KR20140041678A (ko) | 2014-04-04 |
US20140171375A1 (en) | 2014-06-19 |
HRP20201998T1 (hr) | 2021-02-05 |
DK2729179T3 (da) | 2020-12-21 |
CA2837979C (en) | 2021-03-30 |
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