IN2014CN01834A - - Google Patents
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- Publication number
- IN2014CN01834A IN2014CN01834A IN1834CHN2014A IN2014CN01834A IN 2014CN01834 A IN2014CN01834 A IN 2014CN01834A IN 1834CHN2014 A IN1834CHN2014 A IN 1834CHN2014A IN 2014CN01834 A IN2014CN01834 A IN 2014CN01834A
- Authority
- IN
- India
- Prior art keywords
- nucleic acid
- polymerases
- aspects
- useful
- disclosure relates
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 230000003197 catalytic effect Effects 0.000 abstract 2
- 238000012163 sequencing technique Methods 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000011143 downstream manufacturing Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000012252 genetic analysis Methods 0.000 abstract 1
- 238000003205 genotyping method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161522125P | 2011-08-10 | 2011-08-10 | |
| US201161545434P | 2011-10-10 | 2011-10-10 | |
| US201261585133P | 2012-01-10 | 2012-01-10 | |
| US201261643844P | 2012-05-07 | 2012-05-07 | |
| US201261681593P | 2012-08-09 | 2012-08-09 | |
| PCT/US2012/050423 WO2013023176A2 (en) | 2011-08-10 | 2012-08-10 | Polymerase compositions, methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN01834A true IN2014CN01834A (cs) | 2015-05-29 |
Family
ID=46755104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1834CHN2014 IN2014CN01834A (cs) | 2011-08-10 | 2012-08-10 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20130040365A1 (cs) |
| EP (2) | EP2742151B1 (cs) |
| CN (2) | CN107326079B (cs) |
| IN (1) | IN2014CN01834A (cs) |
| LT (1) | LT2742151T (cs) |
| WO (1) | WO2013023176A2 (cs) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013023176A2 (en) * | 2011-08-10 | 2013-02-14 | Life Technologies Corporation | Polymerase compositions, methods of making and using same |
| US11208636B2 (en) | 2011-08-10 | 2021-12-28 | Life Technologies Corporation | Polymerase compositions, methods of making and using same |
| US8906660B2 (en) | 2012-02-01 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Recombinant polymerases with increased phototolerance |
| SG10201802883UA (en) | 2012-04-19 | 2018-05-30 | Life Technologies Corp | Nucleic acid amplification |
| EP2839026B1 (en) | 2012-04-19 | 2016-08-10 | Life Technologies Corporation | Nucleic acid amplification |
| WO2014043143A1 (en) | 2012-09-11 | 2014-03-20 | Life Technologies Corporation | Nucleic acid amplification |
| EP2895620B1 (en) | 2012-09-11 | 2017-08-02 | Life Technologies Corporation | Nucleic acid amplification |
| US9399766B2 (en) | 2012-10-01 | 2016-07-26 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for incorporation of protein shield nucleotide analogs |
| US10683537B2 (en) * | 2012-10-16 | 2020-06-16 | Dna Polymerase Technology, Inc. | Inhibition-resistant polymerases |
| WO2015048766A1 (en) | 2013-09-30 | 2015-04-02 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | A home-based heliox system with carbon dioxide removal |
| ES2938585T3 (es) | 2013-09-30 | 2023-04-12 | Life Technologies Corp | Composiciones de polimerasa, métodos de producción y uso de estas |
| WO2016077324A1 (en) | 2014-11-11 | 2016-05-19 | Life Technologies Corporation | Thiolated nucleotide analogues for nucleic acid synthesis |
| CN113403293B (zh) * | 2014-12-16 | 2024-08-16 | 生命技术公司 | 聚合酶组合物和制造与使用其的方法 |
| JP6736565B2 (ja) | 2015-02-02 | 2020-08-05 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ポリメラーゼバリアント |
| US11091745B2 (en) | 2015-05-12 | 2021-08-17 | Dna Polymerase Technology, Inc. | Mutant polymerases and uses thereof |
| US10526588B2 (en) | 2015-05-14 | 2020-01-07 | Roche Sequencing Solutions, Inc. | Polymerase variants and uses thereof |
| US10344268B2 (en) | 2015-10-01 | 2019-07-09 | Life Technologies Corporation | Polymerase compositions and kits, and methods of using and making the same |
| US10590480B2 (en) | 2016-02-29 | 2020-03-17 | Roche Sequencing Solutions, Inc. | Polymerase variants |
| EP3423575B1 (en) | 2016-02-29 | 2021-06-16 | Genia Technologies, Inc. | Exonuclease deficient polymerases |
| WO2017148860A1 (en) | 2016-02-29 | 2017-09-08 | Genia Technologies, Inc. | Polymerase-template complexes for nanopore sequencing |
| AU2017258523B2 (en) | 2016-04-29 | 2020-08-13 | Pacific Biosciences Of California, Inc. | Method of Nucleic Acid sequence determination |
| US10597643B2 (en) | 2016-04-29 | 2020-03-24 | Omniome, Inc. | Polymerases engineered to reduce nucleotide-independent DNA binding |
| WO2017196676A1 (en) | 2016-05-10 | 2017-11-16 | Life Technologies Corporation | Metal chelation post incorporation detection methods |
| EP3469078B1 (en) | 2016-06-10 | 2024-03-27 | Life Technologies Corporation | Methods and compositions for nucleic acid amplification |
| US10829747B2 (en) | 2016-09-22 | 2020-11-10 | Roche Sequencing Solutions, Inc. | Polymerase variants |
| AU2018208462B2 (en) * | 2017-01-10 | 2021-07-29 | Pacific Biosciences Of California, Inc. | Polymerases engineered to reduce nucleotide-independent DNA binding |
| US12226745B2 (en) | 2017-11-07 | 2025-02-18 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| EP4310196A3 (en) | 2017-11-07 | 2024-04-24 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| GB201721053D0 (en) * | 2017-12-15 | 2018-01-31 | Univ I Tromsø - Norges Arktiske Univ | DNA polymerases |
| WO2019143622A1 (en) | 2018-01-19 | 2019-07-25 | Bio-Rad Laboratories, Inc. | Mutant dna polymerases |
| CN112941155B (zh) * | 2018-05-14 | 2023-07-14 | 北京艾克伦医疗科技有限公司 | 具有茎环结构的dna引物对及其应用 |
| MX2021009482A (es) | 2019-02-11 | 2021-11-12 | Ultima Genomics Inc | Metodos para el analisis de acidos nucleicos. |
| CN116200364A (zh) | 2019-03-10 | 2023-06-02 | 武汉爱博泰克生物科技有限公司 | 用于在提高的盐浓度或体液中扩增的突变型Taq聚合酶 |
| WO2020185702A2 (en) * | 2019-03-13 | 2020-09-17 | Abclonal Science, Inc. | Mutant taq polymerase for faster amplification |
| CN113906148B (zh) | 2019-05-03 | 2024-12-31 | 生命技术公司 | 用于操纵核酸的方法和组合物 |
| US11613738B2 (en) | 2019-05-14 | 2023-03-28 | Abclonal Science, Inc. | Mutant Taq polymerase resistant to inhibition of amplification in the presence of cyanine dye |
| CN111154739B (zh) * | 2020-02-06 | 2021-03-02 | 广州普世利华科技有限公司 | 一种新型重组酶依赖型扩增方法及试剂盒 |
| CN111454926B (zh) * | 2020-05-11 | 2022-10-28 | 南京君华基因科技有限公司 | 一种优化的扩增目标核酸的聚合酶、复合体系及应用 |
| US11649441B2 (en) | 2020-10-07 | 2023-05-16 | Abclonal Science, Inc. | Taq DNA polymerase mutants for probe qPCR |
| CN116802267A (zh) * | 2020-10-23 | 2023-09-22 | 斯宾德尔生物科技公司 | 用于rna合成的组合物和方法 |
| TWI869710B (zh) * | 2021-09-29 | 2025-01-11 | 呈堯 陳 | 用於無模板ｒｎａ合成的核酸聚合酶變體、試劑套組及方法 |
| WO2025144744A1 (en) | 2023-12-29 | 2025-07-03 | Life Technologies Corporation | Enrichment of clonal substrates |
| CN119842661B (zh) * | 2025-03-21 | 2025-07-15 | 中国农业科学院生物技术研究所 | Bst DNA聚合酶突变体及其制备方法与应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3508111A (en) | 1966-09-21 | 1970-04-21 | Ibm | Light emitting semiconductor device with light emission from selected portion(s) of p-n junction |
| US5466591A (en) | 1986-08-22 | 1995-11-14 | Hoffmann-La Roche Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5374553A (en) | 1986-08-22 | 1994-12-20 | Hoffmann-La Roche Inc. | DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| EP0550687B1 (en) * | 1990-09-28 | 1999-06-09 | F. Hoffmann-La Roche Ag | 5' to 3' exonuclease mutations of thermostable dna polymerases |
| EP0517418B1 (en) * | 1991-06-03 | 2003-11-26 | Takara Bio Inc. | A method for cloning of a gene for Pol I type DNA polymerase |
| US5614365A (en) | 1994-10-17 | 1997-03-25 | President & Fellow Of Harvard College | DNA polymerase having modified nucleotide binding site for DNA sequencing |
| US5830714A (en) * | 1996-04-17 | 1998-11-03 | Molecular Biology Resources, Inc. | Biologically active fragment of bacillus stearothermophilus DNA polymerase |
| US6395524B2 (en) | 1996-11-27 | 2002-05-28 | University Of Washington | Thermostable polymerases having altered fidelity and method of identifying and using same |
| CA2283789C (en) * | 1997-03-12 | 2005-07-05 | The Perkin-Elmer Corporation | Dna polymerases having improved labeled nucleotide incorporation properties |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| GB9918150D0 (en) * | 1999-08-03 | 1999-10-06 | Univ Sheffield | Nuclease variant |
| US6329178B1 (en) | 2000-01-14 | 2001-12-11 | University Of Washington | DNA polymerase mutant having one or more mutations in the active site |
| WO2001090337A2 (en) | 2000-05-24 | 2001-11-29 | Third Wave Technologies, Inc. | Detection of rna |
| US6214557B1 (en) | 2000-06-06 | 2001-04-10 | Washington University | Cold sensitive mutant DNA polymerases |
| US20070172866A1 (en) * | 2000-07-07 | 2007-07-26 | Susan Hardin | Methods for sequence determination using depolymerizing agent |
| CN101525660A (zh) | 2000-07-07 | 2009-09-09 | 维西根生物技术公司 | 实时序列测定 |
| GB0022458D0 (en) | 2000-09-13 | 2000-11-01 | Medical Res Council | Directed evolution method |
| US6768004B2 (en) * | 2001-01-11 | 2004-07-27 | Mueller Sybille | Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies |
| WO2002086088A2 (en) * | 2001-04-24 | 2002-10-31 | Li-Cor, Inc. | Polymerases with charge-switch activity and methods of generating such polymerases |
| US20030180741A1 (en) * | 2001-12-21 | 2003-09-25 | Holly Hogrefe | High fidelity DNA polymerase compositions and uses therefor |
| GB0208768D0 (en) * | 2002-04-17 | 2002-05-29 | Univ Newcastle | DNA polymerases |
| AU2004288017B2 (en) | 2003-11-03 | 2009-10-08 | United Kingdom Research And Innovation | Polymerase |
| US7417133B2 (en) | 2004-02-27 | 2008-08-26 | Institut Pasteur | Methods for obtaining thermostable enzymes, DNA polymerase I variants from Thermus aquaticus having new catalytic activities, methods for obtaining the same, and applications of the same |
| US7462475B2 (en) | 2004-05-20 | 2008-12-09 | Dna Poleymerase Technology, Inc. | Use of whole blood in PCR reactions |
| US20060223067A1 (en) | 2005-03-31 | 2006-10-05 | Paolo Vatta | Mutant DNA polymerases and methods of use |
| US8623628B2 (en) | 2005-05-10 | 2014-01-07 | Illumina, Inc. | Polymerases |
| GB0509508D0 (en) * | 2005-05-10 | 2005-06-15 | Solexa Ltd | Improved polymerases |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| ES2648313T3 (es) | 2005-12-22 | 2017-12-29 | Pacific Biosciences Of California, Inc. | Polimerasas para la incorporación de análogos nucleotídicos |
| AU2007296180A1 (en) | 2006-09-14 | 2008-03-20 | Dna Polymerase Technology Inc. | Use of Taq polymerase mutant enzymes for DNA amplification in the presence of PCR inhibitors |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| EP4134667B1 (en) | 2006-12-14 | 2025-11-12 | Life Technologies Corporation | Apparatus for measuring analytes using fet arrays |
| ES2614078T3 (es) | 2008-03-31 | 2017-05-29 | Pacific Biosciences Of California, Inc. | Generación de polimerasas modificadas para precisión mejorada en secuenciación de una única molécula |
| US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| WO2010062779A2 (en) | 2008-11-03 | 2010-06-03 | Kapabiosystems | Modified dna polymerases |
| CN102245761A (zh) | 2008-11-03 | 2011-11-16 | 卡帕生物系统 | 修饰a型dna聚合酶 |
| WO2010111691A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corp | Conjugates of biomolecules to nanoparticles |
| US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
| EP2524036B1 (en) | 2009-07-31 | 2019-06-12 | Agilent Technologies, Inc. | Thermostable type-a dna polymerase mutants with increased polymerization rate and resistance to inhibitors |
| US20110301041A1 (en) * | 2010-02-26 | 2011-12-08 | Life Technologies Corporation | Modified Proteins and Methods of Making and Using Same |
| US20120202276A1 (en) | 2010-02-26 | 2012-08-09 | Life Technologies Corporation | Modified Proteins and Methods of Making and Using Same |
| EP2808401B1 (en) * | 2010-02-26 | 2016-12-14 | Life Technologies Corporation | Method for sequencing using a modified DNA polymerase |
| ES2536978T3 (es) * | 2010-06-18 | 2015-06-01 | F. Hoffmann-La Roche Ag | ADN polimerasas con discriminación incrementada de no correspondencias 3' |
| US9315787B2 (en) | 2011-01-14 | 2016-04-19 | Kapa Biosystems, Inc. | Modified DNA polymerases for improved amplification |
| GB201113430D0 (en) | 2011-08-03 | 2011-09-21 | Fermentas Uab | DNA polymerases |
| WO2013023176A2 (en) * | 2011-08-10 | 2013-02-14 | Life Technologies Corporation | Polymerase compositions, methods of making and using same |
| ES2938585T3 (es) | 2013-09-30 | 2023-04-12 | Life Technologies Corp | Composiciones de polimerasa, métodos de producción y uso de estas |
| US10344268B2 (en) | 2015-10-01 | 2019-07-09 | Life Technologies Corporation | Polymerase compositions and kits, and methods of using and making the same |
-
2012
- 2012-08-10 WO PCT/US2012/050423 patent/WO2013023176A2/en not_active Ceased
- 2012-08-10 EP EP12751661.5A patent/EP2742151B1/en active Active
- 2012-08-10 EP EP17198055.0A patent/EP3293274B1/en active Active
- 2012-08-10 CN CN201710614722.XA patent/CN107326079B/zh active Active
- 2012-08-10 US US13/572,488 patent/US20130040365A1/en not_active Abandoned
- 2012-08-10 LT LTEP12751661.5T patent/LT2742151T/lt unknown
- 2012-08-10 IN IN1834CHN2014 patent/IN2014CN01834A/en unknown
- 2012-08-10 CN CN201280048344.9A patent/CN103857805B/zh active Active
-
2015
- 2015-06-29 US US14/754,203 patent/US9976128B2/en active Active
-
2018
- 2018-04-23 US US15/959,839 patent/US10633641B2/en active Active
-
2021
- 2021-12-20 US US17/645,146 patent/US12338465B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2742151A2 (en) | 2014-06-18 |
| WO2013023176A3 (en) | 2013-04-18 |
| US20180305673A1 (en) | 2018-10-25 |
| LT2742151T (lt) | 2018-02-12 |
| US20150368626A1 (en) | 2015-12-24 |
| US12338465B2 (en) | 2025-06-24 |
| US20220162573A1 (en) | 2022-05-26 |
| CN107326079A (zh) | 2017-11-07 |
| US20130040365A1 (en) | 2013-02-14 |
| CN107326079B (zh) | 2021-04-20 |
| EP3293274A2 (en) | 2018-03-14 |
| US10633641B2 (en) | 2020-04-28 |
| WO2013023176A2 (en) | 2013-02-14 |
| EP3293274B1 (en) | 2020-04-01 |
| CN103857805A (zh) | 2014-06-11 |
| EP3293274A3 (en) | 2018-03-28 |
| EP2742151B1 (en) | 2017-10-25 |
| US9976128B2 (en) | 2018-05-22 |
| CN103857805B (zh) | 2017-07-18 |
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