IN2012DN03348A - - Google Patents

Download PDF

Info

Publication number
IN2012DN03348A
IN2012DN03348A IN3348DEN2012A IN2012DN03348A IN 2012DN03348 A IN2012DN03348 A IN 2012DN03348A IN 3348DEN2012 A IN3348DEN2012 A IN 3348DEN2012A IN 2012DN03348 A IN2012DN03348 A IN 2012DN03348A
Authority
IN
India
Prior art keywords
monoclonal antibodies
methods
progastrin
compositions
present disclosure
Prior art date
Application number
Other languages
English (en)
Inventor
Pannequin Julie
Boudier Laure
Joubert Dominique
Hollande Frederic
Original Assignee
Biorealites
Inst Nat Sante Rech Med
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43086711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2012DN03348(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biorealites, Inst Nat Sante Rech Med, Centre Nat Rech Scient filed Critical Biorealites
Publication of IN2012DN03348A publication Critical patent/IN2012DN03348A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/595Gastrins; Cholecystokinins [CCK]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • General Engineering & Computer Science (AREA)
IN3348DEN2012 2009-10-16 2010-10-15 IN2012DN03348A (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25262509P 2009-10-16 2009-10-16
PCT/EP2010/006329 WO2011045080A2 (en) 2009-10-16 2010-10-15 Monoclonal antibodies to progastrin and their uses

Publications (1)

Publication Number Publication Date
IN2012DN03348A true IN2012DN03348A (ro) 2015-10-23

Family

ID=43086711

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3348DEN2012 IN2012DN03348A (ro) 2009-10-16 2010-10-15

Country Status (42)

Country Link
US (7) US9611320B2 (ro)
EP (2) EP3421493B1 (ro)
JP (3) JP5985987B2 (ro)
KR (2) KR20120091221A (ro)
CN (2) CN102791735B (ro)
AP (1) AP2012006262A0 (ro)
AR (1) AR078659A1 (ro)
AU (1) AU2010306119A1 (ro)
BR (1) BR112012008818B1 (ro)
CA (1) CA2777691C (ro)
CL (1) CL2012000914A1 (ro)
CR (1) CR20120184A (ro)
CU (1) CU24196B1 (ro)
CY (1) CY1120913T1 (ro)
DK (1) DK2488551T3 (ro)
EA (2) EA029271B1 (ro)
EC (1) ECSP12011796A (ro)
ES (2) ES2690943T3 (ro)
GE (1) GEP201706604B (ro)
GT (1) GT201200114A (ro)
HN (1) HN2012000708A (ro)
HR (1) HRP20181645T1 (ro)
IL (2) IL219019B (ro)
IN (1) IN2012DN03348A (ro)
LT (1) LT2488551T (ro)
MA (1) MA33747B1 (ro)
MX (1) MX351635B (ro)
NI (1) NI201200054A (ro)
NZ (2) NZ599971A (ro)
PE (1) PE20121649A1 (ro)
PH (1) PH12012500711B1 (ro)
PL (2) PL3421493T3 (ro)
PT (1) PT2488551T (ro)
RS (1) RS57966B1 (ro)
SG (1) SG10201704933PA (ro)
SI (1) SI2488551T1 (ro)
SM (1) SMT201800628T1 (ro)
TN (1) TN2012000159A1 (ro)
TW (1) TWI537002B (ro)
UA (1) UA106771C2 (ro)
WO (1) WO2011045080A2 (ro)
ZA (1) ZA201202642B (ro)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7854932B2 (en) 2006-12-19 2010-12-21 The Board Of Regents Of The University Of Texas System Immunogenic compositions comprising progastrin and uses thereof
US8136651B2 (en) * 2007-12-14 2012-03-20 The Procter & Gamble Company Method and apparatus for orienting articles
IN2012DN03348A (ro) * 2009-10-16 2015-10-23 Biorealites
US8900588B2 (en) * 2010-01-08 2014-12-02 Les Laboratories Servier Methods for treating breast cancer
US8900817B2 (en) 2010-01-08 2014-12-02 Les Laboratories Servier Progastrin and liver pathologies
ES2754774T3 (es) * 2010-03-24 2020-04-20 Progastrine Et Cancers S A R L Profilaxis de cáncer colorrectal y gastrointestinal
CA2806157C (en) * 2010-07-26 2016-11-22 Les Laboratoires Servier Methods and compositions for liver cancer therapy
US8785603B2 (en) 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
EP2715364A1 (en) 2011-06-01 2014-04-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the risk of developing a colonic neoplasia
JP6450381B2 (ja) * 2013-07-05 2019-01-09 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション がんを処置するための可溶性mic中和モノクローナル抗体
BR112016024214B8 (pt) * 2014-04-18 2023-12-26 Univ New York State Res Found Anticorpo monoclonal parcialmente humanizado, composição farmacêutica e uso de um anticorpo monoclonal
US10023651B2 (en) 2014-04-18 2018-07-17 The Research Foundation For The State University Of New York Humanized anti-TF-antigen antibodies
WO2016066671A1 (en) 2014-10-29 2016-05-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for treating resistant cancers using progastrin inhibitors
EP3349768A4 (en) * 2015-09-15 2019-01-23 The Scripps Research Institute ANTIBODIES FOR THE PRODUCTION OF ANTI-INFLAMMATORY MACROPHAGES AND CORRESPONDING USES
SG11201805605TA (en) * 2015-12-31 2018-07-30 Progastrine Et Cancers S A R L Compositions and methods for detecting and treating ovarian cancer
EP3954998B1 (en) * 2015-12-31 2024-12-25 ECS-Progastrin SA Compositions and methods for detecting and treating gastric cancer
JP6940505B2 (ja) * 2015-12-31 2021-09-29 シンセラス、エス、アー エル、エルSyncerus S.A R.L. 組成物および癌の発生リスクの評価方法
CN110662769B (zh) * 2017-03-30 2023-10-20 普莱戈斯瑞恩癌症有限责任公司 使用前胃泌素结合分子检测和治疗前列腺癌的组合物和方法
US11561225B2 (en) * 2017-03-30 2023-01-24 Progastrine Et Cancers S.À R.L. Compositions and methods for treating lung cancer
DK3720879T3 (da) * 2017-12-05 2022-06-20 Progastrine Et Cancers S A R L Kombinationsterapi mellem anti-progastrin-antistof og immunterapi til behandling af cancer
WO2019110845A1 (en) 2017-12-08 2019-06-13 Ecs-Biotracker Sàrl Radiolabeled progastrin in cancer diagnosis
WO2019145537A1 (en) 2018-01-26 2019-08-01 Ecs-Progastrin Sa Combination of progastrin detection with other cancer biomarkers in cancer diagnosis
AU2019228339B2 (en) * 2018-02-27 2025-02-27 Ecs-Progastrin Sa Progastrin as a biomarker for immunotherapy
TWI793238B (zh) * 2018-12-27 2023-02-21 偉喬生醫股份有限公司 體外檢測生物樣品之胃源性蛋白的方法及套組
WO2021066751A1 (en) * 2019-10-02 2021-04-08 Aslan Pharmaceuticals Pte. Ltd. Antigen specific binding domains and antibody molecules
CN112062846A (zh) * 2020-04-27 2020-12-11 杭州博茵生物技术有限公司 一种g-17单克隆抗体及其应用
CN115785273B (zh) * 2021-09-10 2023-10-31 东莞市朋志生物科技有限公司 一种抗胃蛋白酶原i的抗体及其应用
CN115724949A (zh) * 2022-12-12 2023-03-03 郑州伊美诺生物技术有限公司 一种鼠源lgG单克隆抗体及其制备方法、应用
CN116143920A (zh) * 2022-12-30 2023-05-23 南京岚煜生物科技有限公司 胃泌素17的单克隆抗体及其细胞株的制备方法和应用
EP4509528A1 (en) * 2023-08-16 2025-02-19 Barrelman Biosciences LLC Monoclonal antibodies against veterinary progastrin-like molecules and their uses
CN118126177A (zh) * 2023-11-22 2024-06-04 艾维可生物科技有限公司 抗成熟型胃泌素17的单克隆抗体及其应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
EP1690934A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
CA2124967C (en) 1991-12-17 2008-04-08 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
KR101333168B1 (ko) * 2004-09-22 2013-11-28 리셉터 바이오로직스 인크 프로가스트린에 대한 모노클로날 항체
ES2727306T3 (es) * 2006-05-22 2019-10-15 Inst Nat Sante Rech Med Inhibidores de progastrina en el tratamiento del cáncer de colon
US7854932B2 (en) 2006-12-19 2010-12-21 The Board Of Regents Of The University Of Texas System Immunogenic compositions comprising progastrin and uses thereof
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
IN2012DN03348A (ro) * 2009-10-16 2015-10-23 Biorealites
ES2754774T3 (es) * 2010-03-24 2020-04-20 Progastrine Et Cancers S A R L Profilaxis de cáncer colorrectal y gastrointestinal
CA2806157C (en) * 2010-07-26 2016-11-22 Les Laboratoires Servier Methods and compositions for liver cancer therapy

Also Published As

Publication number Publication date
IL254004B2 (en) 2023-06-01
EP3421493C0 (en) 2024-01-17
HN2012000708A (es) 2015-06-22
JP2013507138A (ja) 2013-03-04
IL219019B (en) 2019-05-30
US10385126B2 (en) 2019-08-20
EP3421493A1 (en) 2019-01-02
AP2012006262A0 (en) 2012-06-30
SMT201800628T1 (it) 2019-01-11
MA33747B1 (fr) 2012-11-01
TW201119675A (en) 2011-06-16
CU20120060A7 (es) 2013-04-19
EA029271B1 (ru) 2018-03-30
KR20120091221A (ko) 2012-08-17
JP6272793B2 (ja) 2018-01-31
HK1178183A1 (zh) 2013-09-06
ECSP12011796A (es) 2012-06-29
IL254004A0 (en) 2017-10-31
WO2011045080A3 (en) 2011-07-07
JP5985987B2 (ja) 2016-09-06
CN102791735A (zh) 2012-11-21
MX351635B (es) 2017-10-23
TWI537002B (zh) 2016-06-11
WO2011045080A2 (en) 2011-04-21
EP2488551B1 (en) 2018-07-25
AR078659A1 (es) 2011-11-23
CN102791735B (zh) 2016-05-18
US11299542B2 (en) 2022-04-12
PL2488551T3 (pl) 2019-01-31
CA2777691C (en) 2018-02-27
US10385125B2 (en) 2019-08-20
KR20150082672A (ko) 2015-07-15
US20180022802A1 (en) 2018-01-25
ES2690943T3 (es) 2018-11-23
EA201791876A1 (ru) 2018-01-31
LT2488551T (lt) 2018-10-25
GEP201706604B (en) 2017-01-25
CN104628857A (zh) 2015-05-20
MX2012004400A (es) 2012-06-27
SG10201704933PA (en) 2017-07-28
RS57966B1 (sr) 2019-01-31
PH12012500711A1 (en) 2012-11-12
HRP20181645T1 (hr) 2018-12-14
PL3421493T3 (pl) 2024-04-29
CY1120913T1 (el) 2019-12-11
US20200002413A1 (en) 2020-01-02
NZ701709A (en) 2016-06-24
US20220195035A1 (en) 2022-06-23
ES2973217T3 (es) 2024-06-19
BR112012008818B1 (pt) 2021-10-19
EP2488551A2 (en) 2012-08-22
JP2017212992A (ja) 2017-12-07
US20170174761A1 (en) 2017-06-22
US20170306012A1 (en) 2017-10-26
KR101640520B1 (ko) 2016-07-19
AU2010306119A1 (en) 2012-05-03
PE20121649A1 (es) 2012-12-08
PT2488551T (pt) 2018-10-31
SI2488551T1 (sl) 2019-01-31
UA106771C2 (uk) 2014-10-10
JP2015145380A (ja) 2015-08-13
NZ599971A (en) 2014-12-24
CA2777691A1 (en) 2011-04-21
CL2012000914A1 (es) 2012-09-14
US20170306011A1 (en) 2017-10-26
NI201200054A (es) 2012-08-20
CR20120184A (es) 2012-08-20
CU24196B1 (es) 2016-09-30
US20110117086A1 (en) 2011-05-19
BR112012008818A2 (en) 2018-05-22
TN2012000159A1 (en) 2013-12-12
DK2488551T3 (en) 2018-10-08
US10385124B2 (en) 2019-08-20
US9611320B2 (en) 2017-04-04
US10377821B2 (en) 2019-08-13
GT201200114A (es) 2014-08-11
EP3421493B1 (en) 2024-01-17
PH12012500711B1 (en) 2019-04-24
ZA201202642B (en) 2013-06-26
IL219019A0 (en) 2012-06-28
EA201200597A1 (ru) 2012-12-28

Similar Documents

Publication Publication Date Title
IN2012DN03348A (ro)
MX2020010639A (es) Anticuerpos humanizados a liv-1 y uso de los mismos para tratar cancer.
JO3097B1 (ar) الأجسام المضادة c-Met
NZ599737A (en) Il-17a antagonists
PH12014502419A1 (en) Specific binding proteins and uses thereof
MX2019004193A (es) Combinacion de anticuerpos anti-kir y anticuerpos anti-pd-1 para tratar cancer.
WO2010017515A3 (en) Breast cancer specific markers and methods of use
MY159553A (en) Detection and treatment of pancreatic, ovarian and other cancers
NZ584787A (en) Inhibition of angiogenesis with a Bv8 antagonist
EA201500219A1 (ru) Антитело против trop-2 человека, обладающее противоопухолевой активностью in vivo
NZ626610A (en) Antibodies that bind csf1r
MX355849B (es) Terapia de combinacion de un anticuerpo cd20 afucosilado y bendamustina.
MY165499A (en) Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
CA2888908A1 (en) Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
NZ607472A (en) Treatment for neoplastic diseases
MX347463B (es) Terapia de combinación de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf.
WO2013149219A3 (en) Fully human antibodies that bind to vegfr2
TH133902A (th) มอนอโคลนัลแอนติบอดีสำหรับโพรแกสตรินและการใช้ประโยชน์ของมอนอโคลนัลแอนติบอดี
TR201905240T4 (tr) LIV-1'e hümanize edilmiş antikorlar ve bunların kanserin tedavisinde kullanımı.
UA104739C2 (en) c-MET ANTIBODIES