MA33747B1 - Anticorps monoclonaux diriges contre la progastrine et leurs utilisations - Google Patents

Anticorps monoclonaux diriges contre la progastrine et leurs utilisations

Info

Publication number
MA33747B1
MA33747B1 MA34864A MA34864A MA33747B1 MA 33747 B1 MA33747 B1 MA 33747B1 MA 34864 A MA34864 A MA 34864A MA 34864 A MA34864 A MA 34864A MA 33747 B1 MA33747 B1 MA 33747B1
Authority
MA
Morocco
Prior art keywords
monoclonal antibodies
antibodies against
methods
progastrin
gastrin
Prior art date
Application number
MA34864A
Other languages
Arabic (ar)
English (en)
Inventor
Julie Pannequin
Laure Boudier
Dominique Joubert
Frédéric Hollande
Original Assignee
Inst Nat Sante Rech Med
Centre Nat Rech Scient
Biorealites
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43086711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33747(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inst Nat Sante Rech Med, Centre Nat Rech Scient, Biorealites filed Critical Inst Nat Sante Rech Med
Publication of MA33747B1 publication Critical patent/MA33747B1/fr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57419Specifically defined cancers of colon
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/595Gastrins; Cholecystokinins [CCK]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des anticorps monoclonaux contre la progastrine, des fragments de ceux-ci, des compositions comprenant les anticorps monoclonaux contre la progastrine, et des procédés de fabrication et d'utilisation d'anticorps monoclonaux contre la progastrine ainsi que des compositions les contenant. La présente invention concerne des procédés de traitement du cancer colorectal avec des anticorps monoclonaux contre la progastrine et des compositions comprenant des anticorps monoclonaux contre la progastrine ou des fragments de ceux-ci. La présente invention concerne en outre des procédés comprenant la détection de la progastrine, y compris des procédés de diagnostic du cancer colorectal et des procédés de surveillance de l'efficacité d'une thérapie anticancéreuse chez des sujets souffrant du cancer colorectal.
MA34864A 2009-10-16 2012-05-11 Anticorps monoclonaux diriges contre la progastrine et leurs utilisations MA33747B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25262509P 2009-10-16 2009-10-16
PCT/EP2010/006329 WO2011045080A2 (fr) 2009-10-16 2010-10-15 Anticorps monoclonaux contre la progastrine et leurs utilisations

Publications (1)

Publication Number Publication Date
MA33747B1 true MA33747B1 (fr) 2012-11-01

Family

ID=43086711

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34864A MA33747B1 (fr) 2009-10-16 2012-05-11 Anticorps monoclonaux diriges contre la progastrine et leurs utilisations

Country Status (41)

Country Link
US (7) US9611320B2 (fr)
EP (2) EP2488551B1 (fr)
JP (3) JP5985987B2 (fr)
KR (2) KR20120091221A (fr)
CN (2) CN104628857A (fr)
AP (1) AP2012006262A0 (fr)
AR (1) AR078659A1 (fr)
AU (1) AU2010306119A1 (fr)
BR (1) BR112012008818B1 (fr)
CA (1) CA2777691C (fr)
CL (1) CL2012000914A1 (fr)
CR (1) CR20120184A (fr)
CU (1) CU24196B1 (fr)
CY (1) CY1120913T1 (fr)
DK (1) DK2488551T3 (fr)
EA (2) EA029271B1 (fr)
EC (1) ECSP12011796A (fr)
ES (2) ES2973217T3 (fr)
GE (1) GEP201706604B (fr)
GT (1) GT201200114A (fr)
HK (1) HK1178183A1 (fr)
HN (1) HN2012000708A (fr)
HR (1) HRP20181645T1 (fr)
IL (2) IL219019B (fr)
IN (1) IN2012DN03348A (fr)
LT (1) LT2488551T (fr)
MA (1) MA33747B1 (fr)
MX (1) MX351635B (fr)
NI (1) NI201200054A (fr)
NZ (2) NZ701709A (fr)
PE (1) PE20121649A1 (fr)
PL (2) PL3421493T3 (fr)
PT (1) PT2488551T (fr)
RS (1) RS57966B1 (fr)
SG (1) SG10201704933PA (fr)
SI (1) SI2488551T1 (fr)
TN (1) TN2012000159A1 (fr)
TW (1) TWI537002B (fr)
UA (1) UA106771C2 (fr)
WO (1) WO2011045080A2 (fr)
ZA (1) ZA201202642B (fr)

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MX351635B (es) * 2009-10-16 2017-10-23 Servier Lab Anticuerpos monoclonales frente a progastrina y sus usos.
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US20150071912A1 (en) * 2010-03-24 2015-03-12 Centre National De La Recherche Scientifique (Cnrs) Prophylaxis of colorectal and gastrointestinal cancer
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JP6450381B2 (ja) * 2013-07-05 2019-01-09 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション がんを処置するための可溶性mic中和モノクローナル抗体
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WO2017048629A1 (fr) * 2015-09-15 2017-03-23 The Scripps Research Institute Anticorps pour la production de macrophages anti-inflammatoires et utilisations associées
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US11614448B2 (en) * 2017-03-30 2023-03-28 Ecs-Progastrin Sa Compositions and methods for detecting prostate cancer
KR102616819B1 (ko) * 2017-03-30 2023-12-21 프로가스트린 에 캔서스 에스.에이 알.엘. 폐암을 치료하기 위한 조성물 및 방법
KR102461238B1 (ko) * 2017-12-05 2022-11-01 프로가스트린 에 캔서스 에스.에이 알.엘. 암을 치료하기 위한 항-프로가스트린 항체와 면역치료 사이의 병용 치료
EP3720510A1 (fr) 2017-12-08 2020-10-14 Ecs-biotracker Sàrl Progastrine radiomarquée dans le diagnostic du cancer
TW201940881A (zh) 2018-01-26 2019-10-16 瑞士商Ecs前胃泌激素公司 在癌症診斷中結合前胃泌激素檢測與其他癌症生物標記的技術
EP3759492A1 (fr) * 2018-02-27 2021-01-06 ECS-Progastrin SA Progastrine en tant que biomarqueur pour l'immunothérapie
TWI793238B (zh) * 2018-12-27 2023-02-21 偉喬生醫股份有限公司 體外檢測生物樣品之胃源性蛋白的方法及套組
CN112062846A (zh) * 2020-04-27 2020-12-11 杭州博茵生物技术有限公司 一种g-17单克隆抗体及其应用
CN115785273B (zh) * 2021-09-10 2023-10-31 东莞市朋志生物科技有限公司 一种抗胃蛋白酶原i的抗体及其应用
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Publication number Publication date
US20220195035A1 (en) 2022-06-23
CR20120184A (es) 2012-08-20
PL2488551T3 (pl) 2019-01-31
BR112012008818A2 (pt) 2018-05-22
JP2013507138A (ja) 2013-03-04
US20110117086A1 (en) 2011-05-19
CN102791735A (zh) 2012-11-21
JP2015145380A (ja) 2015-08-13
EP3421493A1 (fr) 2019-01-02
IL219019B (en) 2019-05-30
IL254004A0 (en) 2017-10-31
TWI537002B (zh) 2016-06-11
NI201200054A (es) 2012-08-20
EA029271B1 (ru) 2018-03-30
US20200002413A1 (en) 2020-01-02
CL2012000914A1 (es) 2012-09-14
IL219019A0 (en) 2012-06-28
SI2488551T1 (sl) 2019-01-31
US10385125B2 (en) 2019-08-20
JP6272793B2 (ja) 2018-01-31
US10377821B2 (en) 2019-08-13
MX2012004400A (es) 2012-06-27
US11299542B2 (en) 2022-04-12
US20170174761A1 (en) 2017-06-22
CA2777691C (fr) 2018-02-27
PL3421493T3 (pl) 2024-04-29
CA2777691A1 (fr) 2011-04-21
GT201200114A (es) 2014-08-11
PE20121649A1 (es) 2012-12-08
HK1178183A1 (zh) 2013-09-06
AR078659A1 (es) 2011-11-23
EP3421493B1 (fr) 2024-01-17
ES2690943T3 (es) 2018-11-23
EA201200597A1 (ru) 2012-12-28
IL254004B2 (en) 2023-06-01
US20170306011A1 (en) 2017-10-26
EP3421493C0 (fr) 2024-01-17
NZ701709A (en) 2016-06-24
WO2011045080A3 (fr) 2011-07-07
TW201119675A (en) 2011-06-16
BR112012008818B1 (pt) 2021-10-19
GEP201706604B (en) 2017-01-25
KR20150082672A (ko) 2015-07-15
PT2488551T (pt) 2018-10-31
DK2488551T3 (en) 2018-10-08
US20170306012A1 (en) 2017-10-26
WO2011045080A2 (fr) 2011-04-21
CN102791735B (zh) 2016-05-18
AP2012006262A0 (en) 2012-06-30
HN2012000708A (es) 2015-06-22
CU24196B1 (es) 2016-09-30
UA106771C2 (uk) 2014-10-10
ECSP12011796A (es) 2012-06-29
EP2488551B1 (fr) 2018-07-25
US20180022802A1 (en) 2018-01-25
CU20120060A7 (es) 2013-04-19
ZA201202642B (en) 2013-06-26
ES2973217T3 (es) 2024-06-19
RS57966B1 (sr) 2019-01-31
HRP20181645T1 (hr) 2018-12-14
NZ599971A (en) 2014-12-24
US10385124B2 (en) 2019-08-20
TN2012000159A1 (en) 2013-12-12
US10385126B2 (en) 2019-08-20
AU2010306119A1 (en) 2012-05-03
MX351635B (es) 2017-10-23
KR20120091221A (ko) 2012-08-17
CY1120913T1 (el) 2019-12-11
US9611320B2 (en) 2017-04-04
JP2017212992A (ja) 2017-12-07
IN2012DN03348A (fr) 2015-10-23
EA201791876A1 (ru) 2018-01-31
CN104628857A (zh) 2015-05-20
SG10201704933PA (en) 2017-07-28
KR101640520B1 (ko) 2016-07-19
LT2488551T (lt) 2018-10-25
EP2488551A2 (fr) 2012-08-22
JP5985987B2 (ja) 2016-09-06

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