MA33747B1 - Anticorps monoclonaux diriges contre la progastrine et leurs utilisations - Google Patents

Anticorps monoclonaux diriges contre la progastrine et leurs utilisations

Info

Publication number
MA33747B1
MA33747B1 MA34864A MA34864A MA33747B1 MA 33747 B1 MA33747 B1 MA 33747B1 MA 34864 A MA34864 A MA 34864A MA 34864 A MA34864 A MA 34864A MA 33747 B1 MA33747 B1 MA 33747B1
Authority
MA
Morocco
Prior art keywords
monoclonal antibodies
antibodies against
methods
progastrin
gastrin
Prior art date
Application number
MA34864A
Other languages
Arabic (ar)
English (en)
Inventor
Julie Pannequin
Laure Boudier
Dominique Joubert
Frédéric Hollande
Original Assignee
Inst Nat Sante Rech Med
Centre Nat Rech Scient
Biorealites
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43086711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33747(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inst Nat Sante Rech Med, Centre Nat Rech Scient, Biorealites filed Critical Inst Nat Sante Rech Med
Publication of MA33747B1 publication Critical patent/MA33747B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/595—Gastrins; Cholecystokinins [CCK]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

La présente invention concerne des anticorps monoclonaux contre la progastrine, des fragments de ceux-ci, des compositions comprenant les anticorps monoclonaux contre la progastrine, et des procédés de fabrication et d'utilisation d'anticorps monoclonaux contre la progastrine ainsi que des compositions les contenant. La présente invention concerne des procédés de traitement du cancer colorectal avec des anticorps monoclonaux contre la progastrine et des compositions comprenant des anticorps monoclonaux contre la progastrine ou des fragments de ceux-ci. La présente invention concerne en outre des procédés comprenant la détection de la progastrine, y compris des procédés de diagnostic du cancer colorectal et des procédés de surveillance de l'efficacité d'une thérapie anticancéreuse chez des sujets souffrant du cancer colorectal.
MA34864A 2009-10-16 2012-05-11 Anticorps monoclonaux diriges contre la progastrine et leurs utilisations MA33747B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25262509P 2009-10-16 2009-10-16
PCT/EP2010/006329 WO2011045080A2 (fr) 2009-10-16 2010-10-15 Anticorps monoclonaux contre la progastrine et leurs utilisations

Publications (1)

Publication Number Publication Date
MA33747B1 true MA33747B1 (fr) 2012-11-01

Family

ID=43086711

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34864A MA33747B1 (fr) 2009-10-16 2012-05-11 Anticorps monoclonaux diriges contre la progastrine et leurs utilisations

Country Status (42)

Country Link
US (7) US9611320B2 (fr)
EP (2) EP3421493B1 (fr)
JP (3) JP5985987B2 (fr)
KR (2) KR101640520B1 (fr)
CN (2) CN102791735B (fr)
AP (1) AP2012006262A0 (fr)
AR (1) AR078659A1 (fr)
AU (1) AU2010306119A1 (fr)
BR (1) BR112012008818B1 (fr)
CA (1) CA2777691C (fr)
CL (1) CL2012000914A1 (fr)
CR (1) CR20120184A (fr)
CU (1) CU24196B1 (fr)
CY (1) CY1120913T1 (fr)
DK (1) DK2488551T3 (fr)
EA (2) EA201791876A1 (fr)
EC (1) ECSP12011796A (fr)
ES (2) ES2973217T3 (fr)
GE (1) GEP201706604B (fr)
GT (1) GT201200114A (fr)
HN (1) HN2012000708A (fr)
HR (1) HRP20181645T1 (fr)
IL (2) IL219019B (fr)
IN (1) IN2012DN03348A (fr)
LT (1) LT2488551T (fr)
MA (1) MA33747B1 (fr)
MX (1) MX351635B (fr)
NI (1) NI201200054A (fr)
NZ (2) NZ599971A (fr)
PE (1) PE20121649A1 (fr)
PH (1) PH12012500711B1 (fr)
PL (2) PL2488551T3 (fr)
PT (1) PT2488551T (fr)
RS (1) RS57966B1 (fr)
SG (1) SG10201704933PA (fr)
SI (1) SI2488551T1 (fr)
SM (1) SMT201800628T1 (fr)
TN (1) TN2012000159A1 (fr)
TW (1) TWI537002B (fr)
UA (1) UA106771C2 (fr)
WO (1) WO2011045080A2 (fr)
ZA (1) ZA201202642B (fr)

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AU2010306119A1 (en) * 2009-10-16 2012-05-03 Centre National De La Recherche Scientifique (Cnrs) Monoclonal antibodies to progastrin and their uses
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AU2011231978B2 (en) * 2010-03-24 2014-12-18 Centre National De La Recherche Scientifique (Cnrs) Prophylaxis of colorectal and gastrointestinal cancer
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EP3708189B1 (fr) * 2013-07-05 2023-11-29 University of Washington through its Center for Commercialization Anticorps monoclonal de neutralisation mic soluble pour le traitement du cancer
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EP3759492A1 (fr) * 2018-02-27 2021-01-06 ECS-Progastrin SA Progastrine en tant que biomarqueur pour l'immunothérapie
TWI793238B (zh) * 2018-12-27 2023-02-21 偉喬生醫股份有限公司 體外檢測生物樣品之胃源性蛋白的方法及套組
WO2021066751A1 (fr) * 2019-10-02 2021-04-08 Aslan Pharmaceuticals Pte. Ltd. Domaines de liaison à l'antigène spécifiques et molécules d'anticorps
CN112062846A (zh) * 2020-04-27 2020-12-11 杭州博茵生物技术有限公司 一种g-17单克隆抗体及其应用
CN115785273B (zh) * 2021-09-10 2023-10-31 东莞市朋志生物科技有限公司 一种抗胃蛋白酶原i的抗体及其应用
CN115724949A (zh) * 2022-12-12 2023-03-03 郑州伊美诺生物技术有限公司 一种鼠源lgG单克隆抗体及其制备方法、应用
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AU2010306119A1 (en) 2012-05-03
CN104628857A (zh) 2015-05-20
IL219019B (en) 2019-05-30
US20220195035A1 (en) 2022-06-23
CA2777691C (fr) 2018-02-27
EP2488551A2 (fr) 2012-08-22
EA029271B1 (ru) 2018-03-30
JP2015145380A (ja) 2015-08-13
HRP20181645T1 (hr) 2018-12-14
DK2488551T3 (en) 2018-10-08
EP3421493C0 (fr) 2024-01-17
HN2012000708A (es) 2015-06-22
JP5985987B2 (ja) 2016-09-06
PL2488551T3 (pl) 2019-01-31
PL3421493T3 (pl) 2024-04-29
NZ599971A (en) 2014-12-24
AR078659A1 (es) 2011-11-23
CN102791735B (zh) 2016-05-18
PH12012500711A1 (en) 2012-11-12
HK1178183A1 (zh) 2013-09-06
KR20150082672A (ko) 2015-07-15
SG10201704933PA (en) 2017-07-28
EP2488551B1 (fr) 2018-07-25
IL254004A0 (en) 2017-10-31
UA106771C2 (uk) 2014-10-10
GT201200114A (es) 2014-08-11
US20170306012A1 (en) 2017-10-26
US20200002413A1 (en) 2020-01-02
EA201791876A1 (ru) 2018-01-31
US11299542B2 (en) 2022-04-12
ZA201202642B (en) 2013-06-26
US20170174761A1 (en) 2017-06-22
PT2488551T (pt) 2018-10-31
US9611320B2 (en) 2017-04-04
CL2012000914A1 (es) 2012-09-14
JP2013507138A (ja) 2013-03-04
LT2488551T (lt) 2018-10-25
PE20121649A1 (es) 2012-12-08
CY1120913T1 (el) 2019-12-11
SI2488551T1 (sl) 2019-01-31
BR112012008818A2 (en) 2018-05-22
MX351635B (es) 2017-10-23
US10385125B2 (en) 2019-08-20
AP2012006262A0 (en) 2012-06-30
KR101640520B1 (ko) 2016-07-19
EP3421493B1 (fr) 2024-01-17
ES2690943T3 (es) 2018-11-23
US20110117086A1 (en) 2011-05-19
WO2011045080A3 (fr) 2011-07-07
CA2777691A1 (fr) 2011-04-21
IL219019A0 (en) 2012-06-28
GEP201706604B (en) 2017-01-25
CU24196B1 (es) 2016-09-30
IN2012DN03348A (fr) 2015-10-23
US10377821B2 (en) 2019-08-13
ECSP12011796A (es) 2012-06-29
TWI537002B (zh) 2016-06-11
SMT201800628T1 (it) 2019-01-11
TW201119675A (en) 2011-06-16
EP3421493A1 (fr) 2019-01-02
TN2012000159A1 (en) 2013-12-12
JP2017212992A (ja) 2017-12-07
IL254004B2 (en) 2023-06-01
MX2012004400A (es) 2012-06-27
RS57966B1 (sr) 2019-01-31
NZ701709A (en) 2016-06-24
CN102791735A (zh) 2012-11-21
US20170306011A1 (en) 2017-10-26
US10385126B2 (en) 2019-08-20
JP6272793B2 (ja) 2018-01-31
BR112012008818B1 (pt) 2021-10-19
CR20120184A (es) 2012-08-20
PH12012500711B1 (en) 2019-04-24
EA201200597A1 (ru) 2012-12-28
NI201200054A (es) 2012-08-20
US20180022802A1 (en) 2018-01-25
US10385124B2 (en) 2019-08-20
CU20120060A7 (es) 2013-04-19
ES2973217T3 (es) 2024-06-19
WO2011045080A2 (fr) 2011-04-21
KR20120091221A (ko) 2012-08-17

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