IN2012DN02129A - - Google Patents

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Publication number
IN2012DN02129A
IN2012DN02129A IN2129DEN2012A IN2012DN02129A IN 2012DN02129 A IN2012DN02129 A IN 2012DN02129A IN 2129DEN2012 A IN2129DEN2012 A IN 2129DEN2012A IN 2012DN02129 A IN2012DN02129 A IN 2012DN02129A
Authority
IN
India
Prior art keywords
brightfield
image
generating
biological sample
fluorescent images
Prior art date
Application number
Other languages
English (en)
Inventor
Can Ali
j gerdes Michael
O Bello Musodiq
Li Qing
Original Assignee
Gen Electric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Electric filed Critical Gen Electric
Publication of IN2012DN02129A publication Critical patent/IN2012DN02129A/en

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T5/00Image enhancement or restoration
    • G06T5/50Image enhancement or restoration using two or more images, e.g. averaging or subtraction
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693Acquisition
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • G01N2021/6423Spectral mapping, video display
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10056Microscopic image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10064Fluorescence image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20212Image combination
    • G06T2207/20221Image fusion; Image merging
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30024Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Multimedia (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Processing Or Creating Images (AREA)
IN2129DEN2012 2009-09-29 2010-09-29 IN2012DN02129A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/569,396 US8269827B2 (en) 2009-09-29 2009-09-29 System and methods for mapping fluorescent images into a bright field color space
PCT/SE2010/051046 WO2011040872A1 (en) 2009-09-29 2010-09-29 System and method for generating a brightfield image using fluorescent images

Publications (1)

Publication Number Publication Date
IN2012DN02129A true IN2012DN02129A (pt) 2015-08-21

Family

ID=43779911

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2129DEN2012 IN2012DN02129A (pt) 2009-09-29 2010-09-29

Country Status (10)

Country Link
US (1) US8269827B2 (pt)
EP (1) EP2483668A4 (pt)
JP (1) JP5631999B2 (pt)
KR (1) KR20120079080A (pt)
CN (1) CN102575990B (pt)
AU (1) AU2010301166A1 (pt)
CA (1) CA2773268A1 (pt)
IN (1) IN2012DN02129A (pt)
RU (1) RU2012111453A (pt)
WO (1) WO2011040872A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8184901B2 (en) * 2007-02-12 2012-05-22 Tcms Transparent Beauty Llc System and method for applying a reflectance modifying agent to change a person's appearance based on a digital image
AU2010307140B2 (en) * 2009-10-12 2014-05-15 Ventana Medical Systems, Inc. Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue
US8639013B2 (en) * 2011-08-17 2014-01-28 General Electric Company System and methods for generating a brightfield image using fluorescent images
WO2013142366A1 (en) * 2012-03-19 2013-09-26 Genetic Innovations, Inc. Devices, systems, and methods for virtual staining
RU2014137125A (ru) * 2012-03-30 2016-05-27 Клариент Дайагностик Сервисез, Инк. Способы формирования изображения биологического образца
US20150065371A1 (en) * 2012-03-30 2015-03-05 Clarient Diagnostic Services, Inc. Immunofluorescence and fluorescent-based nucleic acid analysis on a simgle sample
EP2845138A1 (en) 2012-04-30 2015-03-11 General Electric Company Systems and methods for analyzing biomarker co-localization in a biological tissue
US20150105283A1 (en) * 2012-05-30 2015-04-16 Clarient Diagnostics Services, Inc. Multiplexed diagnosis method for classical hodgkin lymphoma
WO2014065889A2 (en) * 2012-10-28 2014-05-01 Clarient Diagnostic Services, Inc. Multiplexed method for diagnosing classical hodgkin lymphoma
US9779500B2 (en) 2013-07-03 2017-10-03 Konica Minolta, Inc. Image processing device, pathological diagnosis support system, image processing program, and pathological diagnosis support method
US10614287B2 (en) 2014-06-16 2020-04-07 Siemens Healthcare Diagnostics Inc. Virtual staining of cells in digital holographic microscopy images using general adversarial networks
CN108426994B (zh) * 2014-06-16 2020-12-25 西门子医疗保健诊断公司 分析数字全息显微术数据以用于血液学应用
JP6375925B2 (ja) * 2014-12-15 2018-08-22 コニカミノルタ株式会社 画像処理装置、画像処理システム、画像処理プログラム及び画像処理方法
WO2017110974A1 (ja) * 2015-12-24 2017-06-29 コニカミノルタ株式会社 画像処理装置及びプログラム
WO2017212055A1 (en) 2016-06-10 2017-12-14 F. Hoffmann-La Roche Ag System for bright field image simulation
JP6968177B2 (ja) * 2016-12-22 2021-11-17 ベンタナ メディカル システムズ, インコーポレイテッド 一次染色および免疫組織化学画像に基づくコンピュータ採点
TWI659395B (zh) 2017-07-19 2019-05-11 銳準醫光股份有限公司 類h&e影像之合成方法及採用該方法之光學系統
JP6901072B2 (ja) * 2017-08-30 2021-07-14 学校法人 埼玉医科大学 画像処理装置、画像処理方法、画像処理プログラム
JP7200945B2 (ja) 2017-12-01 2023-01-10 ソニーグループ株式会社 画像着色装置、画像着色方法、プログラム、及び画像着色システム
US10824847B2 (en) 2017-12-15 2020-11-03 Verily Life Sciences Llc Generating virtually stained images of unstained samples
US10665000B2 (en) 2018-01-08 2020-05-26 AcuSolutions Inc. Pseudo H and E image producing method and optical system using same
EP3776342A4 (en) 2018-03-30 2021-06-09 The Regents of the University of California METHOD AND SYSTEM FOR DIGITAL COLORING OF MARK-FREE FLUORESCENT IMAGES USING DEPTH LEARNING
TWI683283B (zh) 2018-04-03 2020-01-21 薩摩亞商銳準醫光股份有限公司 一種生物樣本之影像合成方法及採用該方法之光學系統
CN110346291A (zh) * 2018-04-03 2019-10-18 锐准医光股份有限公司 一种生物样本的影像合成方法及采用该方法的光学系统
JP7470339B2 (ja) * 2019-03-06 2024-04-18 学校法人 埼玉医科大学 染色画像推定器学習装置、画像処理装置、染色画像推定器学習方法、画像処理方法、染色画像推定器学習プログラム、及び、画像処理プログラム
US20200388033A1 (en) * 2019-06-10 2020-12-10 Omics Data Automation, Inc. System and method for automatic labeling of pathology images
US11354804B1 (en) 2019-09-27 2022-06-07 Verily Life Sciences Llc Transforming multispectral images to enhanced resolution images enabled by machine learning
CN114731364A (zh) * 2019-10-02 2022-07-08 化学影像公司 分子化学成像与rgb成像的融合
JP2021124861A (ja) * 2020-02-04 2021-08-30 ソニーグループ株式会社 解析装置、解析方法、解析プログラム及び診断支援システム
EP3907497B1 (en) * 2020-05-08 2023-08-02 Leica Microsystems CMS GmbH Apparatus and method for displaying and/or printing images of a specimen including a fluorophore
CN112781958B (zh) * 2021-02-02 2022-07-08 江南大学 一种表征乳液分子特定成分流动性的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2991001A (en) * 1959-04-06 1961-07-04 William L Hughes Resealable container
US5880473A (en) * 1997-07-28 1999-03-09 Applied Imaging, Inc. Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration
US6195451B1 (en) * 1999-05-13 2001-02-27 Advanced Pathology Ststems, Inc. Transformation of digital images
US7018614B2 (en) * 2002-11-05 2006-03-28 Eastern Isotopes, Inc. Stabilization of radiopharmaceuticals labeled with 18-F
WO2005050563A2 (en) * 2003-11-17 2005-06-02 Aureon Biosciences Corporation Pathological tissue mapping
US8320650B2 (en) * 2005-11-30 2012-11-27 Lawrence Livermore National Security, Llc In vivo spectral micro-imaging of tissue
GB0601509D0 (en) 2006-01-26 2006-03-08 Maddison John Method And Apparatus For Aligning Microscope Images
WO2008021681A2 (en) 2006-08-07 2008-02-21 General Electric Company System and methods for analyzing images of tissue samples
US8131476B2 (en) 2006-08-07 2012-03-06 General Electric Company System and method for co-registering multi-channel images of a tissue micro array
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
JP2008139796A (ja) * 2006-12-05 2008-06-19 Keyence Corp 蛍光顕微鏡、蛍光顕微鏡の操作方法、蛍光顕微鏡操作プログラム及びコンピュータで読み取り可能な記録媒体並びに記録した機器
US8244021B2 (en) * 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US20100034791A1 (en) * 2007-02-14 2010-02-11 Drexel University Engineered Lung Tissue Construction for High Throughput Toxicity Screening and Drug Discovery
CA2690815A1 (en) * 2007-06-12 2008-12-18 Case Western Reserve University Targeted cell death
US8791427B2 (en) * 2007-12-26 2014-07-29 Olympus Corporation Biological-specimen observation apparatus
US8712139B2 (en) * 2008-03-21 2014-04-29 General Electric Company Methods and systems for automated segmentation of dense cell populations
US8369600B2 (en) * 2008-03-25 2013-02-05 General Electric Company Method and apparatus for detecting irregularities in tissue microarrays
US20110165566A1 (en) * 2009-07-09 2011-07-07 Wittliff James L Methods of optimizing treatment of breast cancer

Also Published As

Publication number Publication date
US20110074944A1 (en) 2011-03-31
JP5631999B2 (ja) 2014-11-26
CN102575990A (zh) 2012-07-11
KR20120079080A (ko) 2012-07-11
EP2483668A4 (en) 2017-11-15
CA2773268A1 (en) 2011-04-07
AU2010301166A1 (en) 2012-03-29
EP2483668A1 (en) 2012-08-08
RU2012111453A (ru) 2013-11-20
US8269827B2 (en) 2012-09-18
WO2011040872A1 (en) 2011-04-07
JP2013506129A (ja) 2013-02-21
CN102575990B (zh) 2015-06-17

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