IN2012DN00765A - - Google Patents
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- Publication number
- IN2012DN00765A IN2012DN00765A IN765DEN2012A IN2012DN00765A IN 2012DN00765 A IN2012DN00765 A IN 2012DN00765A IN 765DEN2012 A IN765DEN2012 A IN 765DEN2012A IN 2012DN00765 A IN2012DN00765 A IN 2012DN00765A
- Authority
- IN
- India
- Prior art keywords
- medicament
- compound
- formula
- well
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2009/074060 WO2011032320A1 (fr) | 2009-09-21 | 2009-09-21 | Nouveaux dérivés alcényliques d'oxoindole |
| PCT/EP2010/063770 WO2011033099A1 (fr) | 2009-09-21 | 2010-09-20 | Dérivés d'alcène-oxindole et leurs utilisations pour traiter l'obésité, le diabète et l'hyperlipidémie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00765A true IN2012DN00765A (fr) | 2015-06-26 |
Family
ID=43414813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN765DEN2012 IN2012DN00765A (fr) | 2009-09-21 | 2010-09-20 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20110071195A1 (fr) |
| EP (1) | EP2480530A1 (fr) |
| JP (1) | JP2013505281A (fr) |
| KR (1) | KR20120068876A (fr) |
| AU (1) | AU2010297252A1 (fr) |
| BR (1) | BR112012006172A2 (fr) |
| CA (1) | CA2772674A1 (fr) |
| IN (1) | IN2012DN00765A (fr) |
| MX (1) | MX2012002477A (fr) |
| WO (2) | WO2011032320A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011032320A1 (fr) * | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Nouveaux dérivés alcényliques d'oxoindole |
| US20150005353A1 (en) * | 2012-02-10 | 2015-01-01 | Virginia Commonwealth University | 3-(2-amino-ethyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-alkylidene-1,3-dihydro-indol-2-one derivatives as selective sphingosine kinase 2 inhibitors |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2769974A1 (fr) * | 2013-02-21 | 2014-08-27 | Debiopharm S.A. | Nouveau composé activateur de l'AMPK |
| US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| WO2014202528A1 (fr) * | 2013-06-20 | 2014-12-24 | Boehringer Ingelheim International Gmbh | Oxindoles substitués par oléfine ayant une activité sur ampk |
| EP2886541A1 (fr) * | 2013-12-19 | 2015-06-24 | Sanofi | Dérivés d'oxindole, leur préparation et leur utilisation thérapeutique pour traiter les troubles liés à l'AMPK |
| ES2567105B1 (es) * | 2014-09-19 | 2017-02-10 | Consejo Superior De Investigaciones Científicas (Csic) | Derivados de indol para la prevención y/o tratamiento de diabetes ytrastornos metabólicos relacionados |
| CN106619616A (zh) * | 2015-11-04 | 2017-05-10 | 中国科学院上海药物研究所 | 3-烯基吲哚酮类衍生物在制备治疗miri药物中的用途及其药物组合物 |
| EP4153589A4 (fr) | 2020-05-19 | 2024-06-12 | Kallyope, Inc. | Activateurs d'ampk |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2201266T3 (es) * | 1996-01-17 | 2004-03-16 | Taiho Pharmaceutical Company Limited | Inhibidores del espesamiento de la capa intima. |
| EP0984930B1 (fr) * | 1997-05-07 | 2005-04-06 | Sugen, Inc. | Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase |
| DE19816624A1 (de) * | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| JPWO2007032371A1 (ja) * | 2005-09-14 | 2009-03-19 | 大日本住友製薬株式会社 | 摂食調節剤としてのオキシインドール誘導体 |
| AU2007294686B2 (en) * | 2006-09-15 | 2013-10-31 | Equinox Sciences, Llc | Kinase inhibitor compounds |
| ES2553340T3 (es) * | 2007-12-12 | 2015-12-07 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos |
| KR20100115789A (ko) * | 2008-02-04 | 2010-10-28 | 머큐리 테라퓨틱스, 인코포레이티드 | Ａｍｐｋ 조절자 |
| CN102271509A (zh) * | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
| WO2011032320A1 (fr) * | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Nouveaux dérivés alcényliques d'oxoindole |
-
2009
- 2009-09-21 WO PCT/CN2009/074060 patent/WO2011032320A1/fr active Application Filing
-
2010
- 2010-09-14 US US12/881,211 patent/US20110071195A1/en not_active Abandoned
- 2010-09-20 JP JP2012530228A patent/JP2013505281A/ja not_active Ceased
- 2010-09-20 MX MX2012002477A patent/MX2012002477A/es not_active Application Discontinuation
- 2010-09-20 WO PCT/EP2010/063770 patent/WO2011033099A1/fr active Application Filing
- 2010-09-20 IN IN765DEN2012 patent/IN2012DN00765A/en unknown
- 2010-09-20 EP EP10757407A patent/EP2480530A1/fr not_active Withdrawn
- 2010-09-20 CA CA2772674A patent/CA2772674A1/fr not_active Abandoned
- 2010-09-20 AU AU2010297252A patent/AU2010297252A1/en not_active Abandoned
- 2010-09-20 BR BR112012006172A patent/BR112012006172A2/pt not_active IP Right Cessation
- 2010-09-20 KR KR1020127007221A patent/KR20120068876A/ko not_active Application Discontinuation
-
2013
- 2013-01-18 US US13/744,480 patent/US8778973B2/en not_active Expired - Fee Related
-
2014
- 2014-06-03 US US14/294,213 patent/US20140288127A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2480530A1 (fr) | 2012-08-01 |
| US20110071195A1 (en) | 2011-03-24 |
| US20130131114A1 (en) | 2013-05-23 |
| JP2013505281A (ja) | 2013-02-14 |
| US20140288127A1 (en) | 2014-09-25 |
| MX2012002477A (es) | 2012-03-26 |
| US8778973B2 (en) | 2014-07-15 |
| KR20120068876A (ko) | 2012-06-27 |
| CA2772674A1 (fr) | 2011-03-24 |
| WO2011033099A1 (fr) | 2011-03-24 |
| WO2011032320A1 (fr) | 2011-03-24 |
| AU2010297252A1 (en) | 2012-02-02 |
| BR112012006172A2 (pt) | 2016-05-31 |
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