IN2012DN00453A - - Google Patents

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Publication number
IN2012DN00453A
IN2012DN00453A IN453DEN2012A IN2012DN00453A IN 2012DN00453 A IN2012DN00453 A IN 2012DN00453A IN 453DEN2012 A IN453DEN2012 A IN 453DEN2012A IN 2012DN00453 A IN2012DN00453 A IN 2012DN00453A
Authority
IN
India
Prior art keywords
octahydro
indole
preparation
acid hydrochloride
hydrochloride
Prior art date
Application number
Other languages
English (en)
Inventor
R Chemburkar Sanjay
E Reddy Rajarathnam
M Reamer Douglas
T Pavlina John
S Ulrey Stephen
J Kotecki Brian
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of IN2012DN00453A publication Critical patent/IN2012DN00453A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IN453DEN2012 2009-07-16 2010-07-16 IN2012DN00453A (en:Method)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22603009P 2009-07-16 2009-07-16
PCT/US2010/042219 WO2011009021A1 (en) 2009-07-16 2010-07-16 Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril

Publications (1)

Publication Number Publication Date
IN2012DN00453A true IN2012DN00453A (en:Method) 2015-05-15

Family

ID=42585097

Family Applications (1)

Application Number Title Priority Date Filing Date
IN453DEN2012 IN2012DN00453A (en:Method) 2009-07-16 2010-07-16

Country Status (10)

Country Link
US (1) US8288565B2 (en:Method)
EP (1) EP2454235A1 (en:Method)
JP (1) JP2012533563A (en:Method)
CN (1) CN102498098A (en:Method)
AU (1) AU2010273259B2 (en:Method)
CA (1) CA2768239A1 (en:Method)
CO (1) CO6491043A2 (en:Method)
IN (1) IN2012DN00453A (en:Method)
RU (1) RU2012103753A (en:Method)
WO (1) WO2011009021A1 (en:Method)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111620788B (zh) * 2020-04-20 2022-09-30 广东莱佛士制药技术有限公司 一种制备(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487932A (en) 1892-12-13 George b
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
NZ202903A (en) 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
US4490386A (en) * 1982-09-23 1984-12-25 Warner-Lambert Company Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof
US4556655A (en) 1984-09-24 1985-12-03 Schering Corporation Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity
FR2605630B1 (fr) * 1986-10-22 1989-06-30 Roussel Uclaf Procede de preparation de derives de l'octahydroindole et intermediaires de preparation
DE19900205A1 (de) * 1999-01-07 2000-07-13 Basf Ag Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür
WO2004065368A1 (ja) 2003-01-21 2004-08-05 Ohara Chemical Industries, Ltd. トランドラプリル合成中間体の製造方法
PT1354874E (pt) * 2003-04-15 2005-03-31 Servier Lab Novo processo de sintese do acido (2s,3as,7as)-per-hidroindole-2-carboxilico e dos seus esteres e aplicacao a sintese do processo perindopril
SI21507A (sl) 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
WO2005054194A1 (en) * 2003-11-25 2005-06-16 Texcontor Etablissement A method for the preparation of (2s, 3ar, 7as)-octahydro-1h-indole-2-carboxylic acid as key intermediate in the preparation of trandolapril by reacting a cyclohexyl aziridine with a dialkyl malonate
US20070135513A1 (en) 2003-11-28 2007-06-14 Mirko Pogutter Method for producing {n-[1-(s)-carbalkoxy-3-phenylpropyl]-s-alanyl-2s, 3ar, 7as-octahydroindole-2-carboxylic acid} compounds
WO2006014916A2 (en) 2004-07-26 2006-02-09 Dr. Reddy's Laboratories Ltd. Preparation of trandolapril
EP1866327A1 (en) 2005-02-14 2007-12-19 Lupin Ltd. Improved process for preparation of highly pure trandolapril
ATE386718T1 (de) 2005-05-06 2008-03-15 Sochinaz Sa Verfahren zur herstellung von (2s, 3ar, 7as)- octahydroindole-2-carbonsäure und umwandlung zum trandolapril
EP1899300A2 (en) * 2005-07-05 2008-03-19 Cipla Limited Process for the synthesis of the ace inhibitor trandolapril
EP2173714B9 (en) 2007-07-24 2013-04-10 Bristol-Myers Squibb Company Piperidine derivatives as modulators of chemokine receptor activity
CN101423490B (zh) * 2008-06-16 2012-07-18 重庆南松医药科技股份有限公司 群多普利关键中间体（2S,3aR,7as）-八氢－1H－吲哚－2－羧酸的合成方法

Also Published As

Publication number Publication date
CO6491043A2 (es) 2012-07-31
US8288565B2 (en) 2012-10-16
CA2768239A1 (en) 2011-01-20
CN102498098A (zh) 2012-06-13
AU2010273259A1 (en) 2012-02-09
AU2010273259B2 (en) 2013-03-07
RU2012103753A (ru) 2013-08-27
US20110065930A1 (en) 2011-03-17
JP2012533563A (ja) 2012-12-27
EP2454235A1 (en) 2012-05-23
WO2011009021A1 (en) 2011-01-20

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