IN170979B - - Google Patents

Info

Publication number
IN170979B
IN170979B IN687/CAL/90A IN687CA1990A IN170979B IN 170979 B IN170979 B IN 170979B IN 687CA1990 A IN687CA1990 A IN 687CA1990A IN 170979 B IN170979 B IN 170979B
Authority
IN
India
Prior art keywords
alkyl
ethynyl
fluorophenyl
bis
opt
Prior art date
Application number
IN687/CAL/90A
Other languages
English (en)
Inventor
Edit Toth
Jozsef Torley
Dr Sandor Gorog
Dr Laszlo Szporny
Bela Kiss
Dr Eva Palosi
Dr Dora Groo
Dr Istvan Laszlovszky
Dr Erzsebet Lapis
Ferenc Auth
Dr Laszlo Gall
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to IN550/CAL/93A priority Critical patent/IN172010B/en
Publication of IN170979B publication Critical patent/IN170979B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
IN687/CAL/90A 1989-08-10 1990-08-09 IN170979B (fa)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN550/CAL/93A IN172010B (fa) 1989-08-10 1991-07-22

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU894094A HU204276B (en) 1989-08-10 1989-08-10 Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
IN170979B true IN170979B (fa) 1992-06-27

Family

ID=10966866

Family Applications (1)

Application Number Title Priority Date Filing Date
IN687/CAL/90A IN170979B (fa) 1989-08-10 1990-08-09

Country Status (26)

Country Link
US (2) US5132309A (fa)
EP (2) EP0413516B1 (fa)
JP (2) JPH0381277A (fa)
KR (2) KR940002826B1 (fa)
CN (1) CN1025031C (fa)
AT (2) ATE104671T1 (fa)
AU (2) AU621771B2 (fa)
CA (2) CA2023015A1 (fa)
DD (2) DD299428A5 (fa)
DE (2) DE69014008T2 (fa)
DK (1) DK0413516T3 (fa)
ES (2) ES2063923T3 (fa)
FI (1) FI93456C (fa)
HK (1) HK118295A (fa)
HU (2) HU206677B (fa)
IE (1) IE902885A1 (fa)
IL (2) IL95325A (fa)
IN (1) IN170979B (fa)
IS (1) IS3612A7 (fa)
MY (1) MY107240A (fa)
NO (1) NO903511L (fa)
NZ (2) NZ234846A (fa)
PL (2) PL163899B1 (fa)
SG (1) SG59864G (fa)
YU (2) YU150489A (fa)
ZA (3) ZA906299B (fa)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2074981T3 (es) * 1986-12-17 1995-10-01 Glaxo Group Ltd Uso de derivados heterociclicos en el tratamiento de trastornos cognoscitivos.
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
EP0492020A1 (en) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
US5756743A (en) 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!
US6100256A (en) * 1996-12-02 2000-08-08 Merck Sharp & Dohme Ltd. Use of NK-1 receptors antagonists for treating schizophrenic disorders
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
KR20030087248A (ko) * 2002-05-08 2003-11-14 (주)씨엔아이 온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치
EP2443124B1 (en) * 2009-06-16 2014-01-22 Merck Sharp & Dohme Corp. Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones
GB201416352D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
GB201416346D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127065C (fa) * 1964-04-22
CH601304A5 (fa) * 1974-02-12 1978-07-14 Buskine Sa
BE790675A (fr) * 1971-10-29 1973-04-27 Science Union & Cie Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
FR2615515B1 (fr) * 1987-05-22 1989-06-30 Adir Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204530B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost

Also Published As

Publication number Publication date
EP0413516B1 (en) 1994-04-20
IL95325A (en) 1994-06-24
IL95325A0 (en) 1991-06-30
JPH0381277A (ja) 1991-04-05
PL164662B1 (pl) 1994-09-30
AU6080490A (en) 1991-02-14
FI903974A0 (fi) 1990-08-10
NZ234843A (en) 1992-03-26
IL95324A0 (en) 1991-06-30
ES2052179T3 (es) 1994-07-01
US5132309A (en) 1992-07-21
SG59864G (en) 1995-09-01
AU6080390A (en) 1991-02-14
HU903233D0 (en) 1990-10-28
DE69008275D1 (de) 1994-05-26
PL291648A1 (en) 1992-06-01
IS3612A7 (is) 1991-02-11
ATE113951T1 (de) 1994-11-15
KR910004631A (ko) 1991-03-29
NO903511L (no) 1991-02-11
ZA906299B (en) 1991-06-26
JPH0383985A (ja) 1991-04-09
IE902885A1 (en) 1991-02-27
KR940000830B1 (ko) 1994-02-02
ATE104671T1 (de) 1994-05-15
CA2023018C (en) 1995-11-28
FI93456B (fi) 1994-12-30
DE69014008D1 (de) 1994-12-15
AU621238B2 (en) 1992-03-05
IL95324A (en) 1994-02-27
HK118295A (en) 1995-07-28
PL163899B1 (pl) 1994-05-31
ZA906304B (en) 1991-06-26
KR940002826B1 (ko) 1994-04-04
ZA906300B (en) 1991-05-29
EP0413516A3 (en) 1991-11-27
DE69014008T2 (de) 1995-03-23
MY107240A (en) 1995-10-31
CA2023015A1 (en) 1991-02-11
DK0413516T3 (da) 1994-05-24
HUT59375A (en) 1992-05-28
EP0413516A2 (en) 1991-02-20
DD299431A5 (de) 1992-04-16
NO903511D0 (no) 1990-08-09
US5132303A (en) 1992-07-21
CN1049349A (zh) 1991-02-20
NZ234846A (en) 1992-03-26
PL286443A1 (en) 1992-01-13
HU204276B (en) 1991-12-30
EP0412821A3 (en) 1991-11-27
ES2063923T3 (es) 1995-01-16
HU206677B (en) 1992-12-28
DD299428A5 (de) 1992-04-16
HUT55785A (en) 1991-06-28
DE69008275T2 (de) 1994-08-04
EP0412821B1 (en) 1994-11-09
CN1025031C (zh) 1994-06-15
YU150489A (sh) 1992-12-21
AU621771B2 (en) 1992-03-19
CA2023018A1 (en) 1991-02-11
KR910004630A (ko) 1991-03-29
FI93456C (fi) 1995-04-10
YU154090A (sh) 1992-12-21
EP0412821A2 (en) 1991-02-13

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