IL99821A - Antitumor vaccines comprising cells transfected with a gene encoding human il-6 - Google Patents
Antitumor vaccines comprising cells transfected with a gene encoding human il-6Info
- Publication number
- IL99821A IL99821A IL9982191A IL9982191A IL99821A IL 99821 A IL99821 A IL 99821A IL 9982191 A IL9982191 A IL 9982191A IL 9982191 A IL9982191 A IL 9982191A IL 99821 A IL99821 A IL 99821A
- Authority
- IL
- Israel
- Prior art keywords
- cells
- tumor
- dil6
- mice
- vaccine according
- Prior art date
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
- A61K39/00114—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL9982191A IL99821A (en) | 1991-10-22 | 1991-10-22 | Antitumor vaccines comprising cells transfected with a gene encoding human il-6 |
| AT92203217T ATE183101T1 (de) | 1991-10-22 | 1992-10-20 | Anti-tumor impfstoffe, die interleukin-6 transfizierte zellen enthalten |
| DK92203217T DK0538952T3 (da) | 1991-10-22 | 1992-10-20 | Anti-tumorvacciner indeholdende IL-6-transficerede celler |
| EP92203217A EP0538952B1 (en) | 1991-10-22 | 1992-10-20 | Antitumor Vaccines Comprising IL-6 Transfected Cells |
| ES92203217T ES2137172T3 (es) | 1991-10-22 | 1992-10-20 | Vacunas antitumorales que comprenden celulas transfectadas con il-6. |
| DE69229768T DE69229768T2 (de) | 1991-10-22 | 1992-10-20 | Anti-Tumor Impfstoffe, die Interleukin-6 transfizierte Zellen enthalten |
| CA002081043A CA2081043C (en) | 1991-10-22 | 1992-10-21 | Antitumor vaccines comprising il-6 transfected cells |
| GR990402877T GR3031785T3 (en) | 1991-10-22 | 1999-11-08 | Antitumor Vaccines Comprising IL-6 Transfected Cells. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL9982191A IL99821A (en) | 1991-10-22 | 1991-10-22 | Antitumor vaccines comprising cells transfected with a gene encoding human il-6 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL99821A0 IL99821A0 (en) | 1992-08-18 |
| IL99821A true IL99821A (en) | 1996-07-23 |
Family
ID=11062992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9982191A IL99821A (en) | 1991-10-22 | 1991-10-22 | Antitumor vaccines comprising cells transfected with a gene encoding human il-6 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0538952B1 (es) |
| AT (1) | ATE183101T1 (es) |
| CA (1) | CA2081043C (es) |
| DE (1) | DE69229768T2 (es) |
| DK (1) | DK0538952T3 (es) |
| ES (1) | ES2137172T3 (es) |
| GR (1) | GR3031785T3 (es) |
| IL (1) | IL99821A (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0599077A3 (en) * | 1992-10-29 | 1994-11-23 | Yeda Res & Dev | Antimetastatic vaccine. |
| PL190445B1 (pl) * | 1995-05-15 | 2005-12-30 | Akademia Medyczna Im K Marcink | Genetyczna szczepionka przeciwrakowa |
| CA2229543A1 (en) | 1995-08-18 | 1997-02-27 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6761892B1 (en) | 1995-08-18 | 2004-07-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6277368B1 (en) | 1996-07-25 | 2001-08-21 | The Regents Of The University Of California | Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine |
| US6087174A (en) * | 1996-12-26 | 2000-07-11 | Johns Hopkins University, School Of Medicine | Growth medium for primary pancreatic tumor cell culture |
| AU8392898A (en) * | 1997-07-14 | 1999-02-10 | Powerject Vaccines, Inc. | Method of dna vaccination using dna encoding antigen and encoding il6 |
| US7420037B2 (en) | 2003-02-13 | 2008-09-02 | Antigenics Inc. | Heat shock protein-based vaccines and immunotherapies |
| US7309491B2 (en) | 2003-04-11 | 2007-12-18 | Antigenics Inc. | Heat shock protein-based vaccines and immunotherapies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3922444A1 (de) * | 1988-03-01 | 1991-01-10 | Deutsches Krebsforsch | Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen |
| CA2091346C (en) * | 1990-09-14 | 2007-04-24 | Philip Frost | Methods and compositions for genetic therapy and potentiation of anti-tumor immunity |
-
1991
- 1991-10-22 IL IL9982191A patent/IL99821A/en not_active IP Right Cessation
-
1992
- 1992-10-20 DE DE69229768T patent/DE69229768T2/de not_active Expired - Fee Related
- 1992-10-20 ES ES92203217T patent/ES2137172T3/es not_active Expired - Lifetime
- 1992-10-20 AT AT92203217T patent/ATE183101T1/de not_active IP Right Cessation
- 1992-10-20 EP EP92203217A patent/EP0538952B1/en not_active Expired - Lifetime
- 1992-10-20 DK DK92203217T patent/DK0538952T3/da active
- 1992-10-21 CA CA002081043A patent/CA2081043C/en not_active Expired - Fee Related
-
1999
- 1999-11-08 GR GR990402877T patent/GR3031785T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE183101T1 (de) | 1999-08-15 |
| DE69229768T2 (de) | 2000-05-31 |
| DK0538952T3 (da) | 2000-03-13 |
| CA2081043C (en) | 2006-01-10 |
| GR3031785T3 (en) | 2000-02-29 |
| CA2081043A1 (en) | 1993-04-23 |
| EP0538952B1 (en) | 1999-08-11 |
| ES2137172T3 (es) | 1999-12-16 |
| EP0538952A1 (en) | 1993-04-28 |
| DE69229768D1 (de) | 1999-09-16 |
| IL99821A0 (en) | 1992-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |