IL99415A0 - Dioxabicyclooctane derivatives,process for their preparation and squalene synthetase inhibiting compositions containing them - Google Patents

Dioxabicyclooctane derivatives,process for their preparation and squalene synthetase inhibiting compositions containing them

Info

Publication number
IL99415A0
IL99415A0 IL99415A IL9941591A IL99415A0 IL 99415 A0 IL99415 A0 IL 99415A0 IL 99415 A IL99415 A IL 99415A IL 9941591 A IL9941591 A IL 9941591A IL 99415 A0 IL99415 A0 IL 99415A0
Authority
IL
Israel
Prior art keywords
dioxabicyclooctane
derivatives
preparation
compositions containing
squalene synthetase
Prior art date
Application number
IL99415A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/582,452 external-priority patent/US5102907A/en
Priority claimed from US07/582,303 external-priority patent/US5026554A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL99415A0 publication Critical patent/IL99415A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL99415A 1990-09-13 1991-09-05 Dioxabicyclooctane derivatives,process for their preparation and squalene synthetase inhibiting compositions containing them IL99415A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58245390A 1990-09-13 1990-09-13
US07/582,452 US5102907A (en) 1990-09-13 1990-09-13 Novel squalene synthetase inhibitors
US07/582,303 US5026554A (en) 1990-09-13 1990-09-13 Method of inhibiting fungal growth using squalene synthetase inhibitors

Publications (1)

Publication Number Publication Date
IL99415A0 true IL99415A0 (en) 1992-08-18

Family

ID=27416377

Family Applications (1)

Application Number Title Priority Date Filing Date
IL99415A IL99415A0 (en) 1990-09-13 1991-09-05 Dioxabicyclooctane derivatives,process for their preparation and squalene synthetase inhibiting compositions containing them

Country Status (12)

Country Link
EP (1) EP0475706A1 (pt)
JP (1) JPH04360889A (pt)
KR (1) KR920006360A (pt)
AU (1) AU640520B2 (pt)
CA (1) CA2050739A1 (pt)
FI (1) FI914295A7 (pt)
IE (1) IE913221A1 (pt)
IL (1) IL99415A0 (pt)
MX (1) MX9100998A (pt)
NO (1) NO913612L (pt)
NZ (1) NZ239663A (pt)
PT (1) PT98901A (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97251A0 (en) * 1990-03-21 1992-05-25 Merck & Co Inc Antihypercholesterolemic 2,8-dioxabicyclo(3,2,1)octane derivatives,their preparation and pharmaceutical compositions containing them
YU49292A (sh) * 1991-05-10 1995-01-31 Merck And Co.Inc. Nova jedinjenja koja snižavaju holesterol
US5256689A (en) * 1991-05-10 1993-10-26 Merck & Co., Inc. Cholesterol lowering compounds
MX9202156A (es) * 1991-05-10 1993-08-01 Merck & Co Inc Novedosos compuestos para reducir el colesterol.
AU2230292A (en) * 1991-07-16 1993-02-23 Glaxo Group Limited Cyclic ketal derivatives
EP0526936A3 (en) * 1991-08-02 1993-05-05 Merck & Co. Inc. Cholesterol-lowering agents
US5364948A (en) * 1991-08-02 1994-11-15 Merck & Co., Inc. Biologically active compounds isolated from aerobic fermentation of Trichoderma viride
GB2261373A (en) * 1991-11-15 1993-05-19 Merck & Co Inc Inhibitors of farnesyl protein transferase as anti-cancer agents
US5294627A (en) * 1992-08-27 1994-03-15 Merck & Co., Inc. Directed biosynthesis of biologically active compounds
US5726306A (en) * 1992-04-20 1998-03-10 Takeda Chemical Industries, Ltd. 4,1-benzoxazepin derivatives and their use
DE69332792T2 (de) * 1992-04-20 2004-01-15 Takeda Chemical Industries Ltd 4,1-Benzoxazepinderivate als Squalen-Synthetase Inhibitoren und ihre Verwendung zur Behandlung von Hypercholesterämie und als Fungizide
EP0568946A1 (en) * 1992-05-08 1993-11-10 Takeda Chemical Industries, Ltd. Compound TAN-1607A, its derivatives, their production, and use thereof
US5283256A (en) * 1992-07-22 1994-02-01 Merck & Co., Inc. Cholesterol-lowering agents
US5310949A (en) * 1992-09-02 1994-05-10 Merck & Co., Inc. Cholesterol lowering compounds
US5322855A (en) * 1992-10-19 1994-06-21 Merck & Co., Inc. Cholesterol lowering compounds
US5447717A (en) * 1993-02-25 1995-09-05 Merck & Co., Inc. Cholesterol-lowering agents
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97251A0 (en) * 1990-03-21 1992-05-25 Merck & Co Inc Antihypercholesterolemic 2,8-dioxabicyclo(3,2,1)octane derivatives,their preparation and pharmaceutical compositions containing them
DE69214127T2 (de) * 1991-01-09 1997-02-13 Glaxo Group Ltd Überbrückte, cyclische ketale
GB9100431D0 (en) * 1991-01-09 1991-02-20 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
IE913221A1 (en) 1992-02-25
FI914295A0 (fi) 1991-09-12
MX9100998A (es) 1992-05-04
JPH04360889A (ja) 1992-12-14
AU640520B2 (en) 1993-08-26
CA2050739A1 (en) 1992-03-14
AU8386891A (en) 1992-03-19
NO913612D0 (no) 1991-09-12
KR920006360A (ko) 1992-04-27
NO913612L (no) 1992-03-16
FI914295L (fi) 1992-03-14
EP0475706A1 (en) 1992-03-18
NZ239663A (en) 1993-07-27
PT98901A (pt) 1992-08-31
FI914295A7 (fi) 1992-03-14

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