DE69214127T2 - Überbrückte, cyclische ketale - Google Patents

Überbrückte, cyclische ketale

Info

Publication number
DE69214127T2
DE69214127T2 DE69214127T DE69214127T DE69214127T2 DE 69214127 T2 DE69214127 T2 DE 69214127T2 DE 69214127 T DE69214127 T DE 69214127T DE 69214127 T DE69214127 T DE 69214127T DE 69214127 T2 DE69214127 T2 DE 69214127T2
Authority
DE
Germany
Prior art keywords
compounds
bridged cyclic
cyclic ketals
animals
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69214127T
Other languages
English (en)
Other versions
DE69214127D1 (de
Inventor
Philip James Sidebottom
Michael George Lester
Panayiotis Alexandro Procopiou
Nigel Stephen Watson
Richard Bell
Gerard Martin Paul Giblin
Esme Joan Bailey
Barrie Edward Kirk
Colin Smith
Jan Josef Scicinski
Barry Clive Ross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919100418A external-priority patent/GB9100418D0/en
Priority claimed from GB919100429A external-priority patent/GB9100429D0/en
Priority claimed from GB919100430A external-priority patent/GB9100430D0/en
Priority claimed from GB919100428A external-priority patent/GB9100428D0/en
Priority claimed from GB919116600A external-priority patent/GB9116600D0/en
Priority claimed from GB919116688A external-priority patent/GB9116688D0/en
Priority claimed from GB919117109A external-priority patent/GB9117109D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE69214127D1 publication Critical patent/DE69214127D1/de
Application granted granted Critical
Publication of DE69214127T2 publication Critical patent/DE69214127T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
DE69214127T 1991-01-09 1992-01-05 Überbrückte, cyclische ketale Expired - Fee Related DE69214127T2 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB919100428A GB9100428D0 (en) 1991-01-09 1991-01-09 Chemical compounds
GB919100418A GB9100418D0 (en) 1991-01-09 1991-01-09 Chemical compounds
GB919100430A GB9100430D0 (en) 1991-01-09 1991-01-09 Chemical compounds
GB919100429A GB9100429D0 (en) 1991-01-09 1991-01-09 Chemical compounds
GB919116600A GB9116600D0 (en) 1991-08-01 1991-08-01 Chemical compounds
GB919116688A GB9116688D0 (en) 1991-08-02 1991-08-02 Chemical compounds
GB919117109A GB9117109D0 (en) 1991-08-07 1991-08-07 Chemical compounds
PCT/EP1992/000017 WO1992012159A1 (en) 1991-01-09 1992-01-05 Bridged cyclic ketal derivatives

Publications (2)

Publication Number Publication Date
DE69214127D1 DE69214127D1 (de) 1996-10-31
DE69214127T2 true DE69214127T2 (de) 1997-02-13

Family

ID=27562848

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69214127T Expired - Fee Related DE69214127T2 (de) 1991-01-09 1992-01-05 Überbrückte, cyclische ketale

Country Status (10)

Country Link
EP (2) EP0569386B1 (de)
JP (1) JPH06504774A (de)
AT (1) ATE143369T1 (de)
AU (1) AU661469B2 (de)
CA (1) CA2100257A1 (de)
DE (1) DE69214127T2 (de)
IE (1) IE920056A1 (de)
IL (1) IL100612A (de)
NZ (1) NZ241254A (de)
WO (1) WO1992012159A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ239663A (en) * 1990-09-13 1993-07-27 Merck & Co Inc Ester derivatives of dioxabicyclo(3,2,1)-octane, medicaments, and a fungus which makes them
US5256689A (en) * 1991-05-10 1993-10-26 Merck & Co., Inc. Cholesterol lowering compounds
MX9202156A (es) * 1991-05-10 1993-08-01 Merck & Co Inc Novedosos compuestos para reducir el colesterol.
US5468771A (en) * 1991-08-07 1995-11-21 Merck & Co., Inc. Cholesterol lowering compound
US5262435A (en) * 1992-02-10 1993-11-16 Merck & Co., Inc. Cholesterol lowering compounds
US5302604A (en) * 1992-03-09 1994-04-12 Merck & Co., Inc. Cholesterol lowering compounds produced by directed biosynthesis
US5294627A (en) * 1992-08-27 1994-03-15 Merck & Co., Inc. Directed biosynthesis of biologically active compounds
GB9205140D0 (en) * 1992-03-10 1992-04-22 Glaxo Group Ltd Chemical compounds
GB9205136D0 (en) * 1992-03-10 1992-04-22 Glaxo Group Ltd Chemical compounds
US5258401A (en) * 1992-07-10 1993-11-02 Merck & Co., Inc. Cholesterol lowering compounds
US5369125A (en) * 1992-07-17 1994-11-29 Merck & Co., Inc. Cholesterol-lowering agents
US5283256A (en) * 1992-07-22 1994-02-01 Merck & Co., Inc. Cholesterol-lowering agents
US5270332A (en) * 1992-08-21 1993-12-14 Merck & Co., Inc. Cholesteral lowering agents
US5326783A (en) * 1992-08-25 1994-07-05 Merck & Co., Inc. Cholesterol lowering compounds
US5278320A (en) * 1992-09-11 1994-01-11 Merck & Co., Inc. Cholesterol lowering compounds produced by directed biosynthesis
US5332728A (en) * 1992-11-23 1994-07-26 Bristol-Myers Squibb Company Method for treating a fungal infection
US5447717A (en) * 1993-02-25 1995-09-05 Merck & Co., Inc. Cholesterol-lowering agents
US5712261A (en) * 1993-10-04 1998-01-27 Magnin; David R. Method for preventing or treating hypertriglyceridemia
US5430055A (en) * 1994-04-08 1995-07-04 Pfizer Inc. Inhibitor of squalene synthase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH606071A5 (en) * 1972-05-30 1978-10-13 Ciba Geigy Ag Fibrinolytic anhydro-furanose ether derivs.
US4837205A (en) * 1986-09-02 1989-06-06 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US5026554A (en) * 1990-09-13 1991-06-25 Merck & Co., Inc. Method of inhibiting fungal growth using squalene synthetase inhibitors
IL96440A (en) * 1990-11-22 1996-07-23 Shlomo Elfanbaum Method of using a play ladder
AU1158292A (en) * 1991-01-09 1992-08-17 Glaxo Group Limited Cyclic ketal derivatives
GB9105152D0 (en) * 1991-03-12 1991-04-24 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
CA2100257A1 (en) 1992-07-10
EP0497091A1 (de) 1992-08-05
ATE143369T1 (de) 1996-10-15
AU661469B2 (en) 1995-07-27
NZ241254A (en) 1993-08-26
JPH06504774A (ja) 1994-06-02
EP0569386B1 (de) 1996-09-25
IE920056A1 (en) 1992-07-15
IL100612A (en) 1996-03-31
WO1992012159A1 (en) 1992-07-23
EP0569386A1 (de) 1993-11-18
DE69214127D1 (de) 1996-10-31
AU1156092A (en) 1992-08-17
IL100612A0 (en) 1992-09-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee