GB2276619A - Cyclic ketal derivatives - Google Patents

Cyclic ketal derivatives

Info

Publication number
GB2276619A
GB2276619A GB9405909A GB9405909A GB2276619A GB 2276619 A GB2276619 A GB 2276619A GB 9405909 A GB9405909 A GB 9405909A GB 9405909 A GB9405909 A GB 9405909A GB 2276619 A GB2276619 A GB 2276619A
Authority
GB
United Kingdom
Prior art keywords
compounds
hydrogen atom
animals
cyclic ketal
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9405909A
Other versions
GB9405909D0 (en
Inventor
Brian Arthur Michael Rudd
Brian Cox
Richard Malcolm Hall
Richard Stephen Hale
Philip James Sidebottom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of GB9405909D0 publication Critical patent/GB9405909D0/en
Publication of GB2276619A publication Critical patent/GB2276619A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds are described of formula (I) and salts thereof; wherein R<1> represents a hydrogen atom or an acetyl group; R<2>, R<3> and R<4> may each independently represent a hydrogen atom or a methyl group; and R<5> represents a hydrogen atom or a group (II). These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the invention may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals. <IMAGE>
GB9405909A 1991-10-08 1994-03-24 Cyclic ketal derivatives Withdrawn GB2276619A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919121380A GB9121380D0 (en) 1991-10-08 1991-10-08 Chemical compounds
PCT/EP1992/002294 WO1993007151A1 (en) 1991-10-08 1992-10-02 Cyclic ketal derivatives

Publications (2)

Publication Number Publication Date
GB9405909D0 GB9405909D0 (en) 1994-06-08
GB2276619A true GB2276619A (en) 1994-10-05

Family

ID=10702619

Family Applications (2)

Application Number Title Priority Date Filing Date
GB919121380A Pending GB9121380D0 (en) 1991-10-08 1991-10-08 Chemical compounds
GB9405909A Withdrawn GB2276619A (en) 1991-10-08 1994-03-24 Cyclic ketal derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB919121380A Pending GB9121380D0 (en) 1991-10-08 1991-10-08 Chemical compounds

Country Status (4)

Country Link
AU (1) AU2686692A (en)
GB (2) GB9121380D0 (en)
MX (1) MX9205748A (en)
WO (1) WO1993007151A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506262A (en) * 1991-05-10 1996-04-09 Merck & Co., Inc. Cholesterol lowering compounds
US5294627A (en) * 1992-08-27 1994-03-15 Merck & Co., Inc. Directed biosynthesis of biologically active compounds
US5302604A (en) * 1992-03-09 1994-04-12 Merck & Co., Inc. Cholesterol lowering compounds produced by directed biosynthesis
US5430055A (en) * 1994-04-08 1995-07-04 Pfizer Inc. Inhibitor of squalene synthase

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053425A (en) * 1990-03-21 1991-10-01 Merck & Co., Inc. Novel anti-fungal compounds
EP0450812A1 (en) * 1990-03-21 1991-10-09 Merck & Co. Inc. Antihypercholesterolemics

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053425A (en) * 1990-03-21 1991-10-01 Merck & Co., Inc. Novel anti-fungal compounds
EP0450812A1 (en) * 1990-03-21 1991-10-09 Merck & Co. Inc. Antihypercholesterolemics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Antibiotics 45(5) 648-658 (1972) *

Also Published As

Publication number Publication date
WO1993007151A1 (en) 1993-04-15
GB9405909D0 (en) 1994-06-08
AU2686692A (en) 1993-05-03
GB9121380D0 (en) 1991-11-20
MX9205748A (en) 1993-04-01

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)