IL99211A - History of piperazinyl, their preparation and pharmaceutical preparations containing them - Google Patents
History of piperazinyl, their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL99211A IL99211A IL9921191A IL9921191A IL99211A IL 99211 A IL99211 A IL 99211A IL 9921191 A IL9921191 A IL 9921191A IL 9921191 A IL9921191 A IL 9921191A IL 99211 A IL99211 A IL 99211A
- Authority
- IL
- Israel
- Prior art keywords
- mmol
- toluene
- propyl
- piperazine
- ether
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK203990A DK203990D0 (da) | 1990-08-24 | 1990-08-24 | Piperazinylderivater |
Publications (2)
Publication Number | Publication Date |
---|---|
IL99211A0 IL99211A0 (en) | 1992-07-15 |
IL99211A true IL99211A (en) | 1996-01-31 |
Family
ID=8109641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9921191A IL99211A (en) | 1990-08-24 | 1991-08-16 | History of piperazinyl, their preparation and pharmaceutical preparations containing them |
Country Status (16)
Country | Link |
---|---|
US (1) | US5246935A (fr) |
EP (1) | EP0544765B1 (fr) |
JP (1) | JPH06500546A (fr) |
AT (1) | ATE125802T1 (fr) |
AU (1) | AU653956B2 (fr) |
CA (1) | CA2089768A1 (fr) |
DE (1) | DE69111815T2 (fr) |
DK (2) | DK203990D0 (fr) |
FI (1) | FI930799A (fr) |
IE (1) | IE73475B1 (fr) |
IL (1) | IL99211A (fr) |
NO (1) | NO930631L (fr) |
NZ (1) | NZ239502A (fr) |
PT (1) | PT98768B (fr) |
WO (1) | WO1992003426A1 (fr) |
ZA (1) | ZA916652B (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364849A (en) * | 1989-04-22 | 1994-11-15 | John Wyeth & Brother, Limited | 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives |
US5436246A (en) * | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
WO1997035584A1 (fr) * | 1996-03-25 | 1997-10-02 | Eli Lilly And Company | Procede de traitement de la douleur |
CA2248873A1 (fr) * | 1996-03-25 | 1997-10-02 | Daniel Edward Womer | Procede de traitement de la douleur |
CN1494907A (zh) * | 1996-03-25 | 2004-05-12 | 治疗疼痛的药物组合物 | |
FR2753968B1 (fr) * | 1996-09-27 | 1998-11-27 | Sod Conseils Rech Applic | Nouvelles heteroaryloxyethylamines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
US6344458B1 (en) | 1998-12-17 | 2002-02-05 | American Home Products Corporation | Piperazine ethylamide derivatives |
US6638970B2 (en) | 2000-02-22 | 2003-10-28 | Cv Therapeutics, Inc. | Substituted alkylene diamine compounds |
AU2001267421A1 (en) * | 2000-05-12 | 2001-11-20 | Solvay Pharmaceuticals B.V. | Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders |
FR2821356A1 (fr) * | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
SE0103649D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinoline compounds |
SE0103648D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinolone compounds |
US6750367B2 (en) * | 2002-05-09 | 2004-06-15 | Bayer Polymers Llc | Tetralin isocyanates |
NZ538713A (en) | 2002-08-12 | 2007-01-26 | Takeda Chemical Industries Ltd | Fused benzene derivative and use |
CA2643983A1 (fr) * | 2006-02-21 | 2007-08-30 | Amgen, Inc. | Derives cinnoline comme inhibiteurs de phosphodiesterase 10 |
AU2010217772B2 (en) * | 2009-02-26 | 2014-10-23 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of utilizing arylpiperazine derivatives |
CN104884064A (zh) | 2012-12-24 | 2015-09-02 | 纽洛佳斯特拉斯公司 | 用于治疗胃肠道病症的方法 |
US9844554B2 (en) | 2014-06-24 | 2017-12-19 | Neurogastrx, Inc. | Prodrugs of metopimazine |
MA41168A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
EP3587398A1 (fr) * | 2017-02-24 | 2020-01-01 | Shenzhen Linglan Bio-pharmaceutical Technology Co., Ltd | Nouveau ligand sélectif pour le récepteur dopaminergique d3, procédé de préparation correspondant et application pharmaceutique correspondante |
US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2836595A (en) * | 1958-05-27 | Piperazine derivatives and process for | ||
US3138597A (en) * | 1964-06-23 | Phenylpiperazinylalkyl carbamates | ||
CA683208A (en) * | 1964-03-31 | Hayao Shin | Phenylpiperazinylalkyl esters and amides | |
GB952142A (en) * | 1961-05-26 | 1964-03-11 | Miles Lab | Phenylpiperazinylalkyl carbamates |
US4202898A (en) * | 1978-06-05 | 1980-05-13 | Synthelabo | Method of treating anxiety and depression |
AU532411B2 (en) * | 1979-03-01 | 1983-09-29 | Duphar International Research B.V. | Phenyl piperazine derivatives |
GB8303946D0 (en) * | 1983-02-12 | 1983-03-16 | Recordati Chem Pharm | Antihypertensive n-piperazinylalkanoylanilides |
US4882432A (en) * | 1989-01-09 | 1989-11-21 | American Home Products Corporation | Polycyclic-carbamic acid piperazinoalkyl esters and amides |
DK0402644T3 (da) * | 1989-05-19 | 1996-01-02 | Hoechst Roussel Pharma | N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter |
FR2655988B1 (fr) * | 1989-12-20 | 1994-05-20 | Adir Cie | Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1990
- 1990-08-24 DK DK203990A patent/DK203990D0/da not_active Application Discontinuation
-
1991
- 1991-08-13 US US07/744,556 patent/US5246935A/en not_active Expired - Fee Related
- 1991-08-16 IL IL9921191A patent/IL99211A/en active IP Right Grant
- 1991-08-22 NZ NZ23950291A patent/NZ239502A/en unknown
- 1991-08-22 ZA ZA916652A patent/ZA916652B/xx unknown
- 1991-08-23 AU AU84413/91A patent/AU653956B2/en not_active Ceased
- 1991-08-23 DK DK91915381.7T patent/DK0544765T3/da active
- 1991-08-23 AT AT91915381T patent/ATE125802T1/de not_active IP Right Cessation
- 1991-08-23 WO PCT/DK1991/000244 patent/WO1992003426A1/fr active IP Right Grant
- 1991-08-23 EP EP91915381A patent/EP0544765B1/fr not_active Expired - Lifetime
- 1991-08-23 CA CA002089768A patent/CA2089768A1/fr not_active Abandoned
- 1991-08-23 PT PT98768A patent/PT98768B/pt not_active IP Right Cessation
- 1991-08-23 IE IE298391A patent/IE73475B1/en not_active IP Right Cessation
- 1991-08-23 JP JP3514325A patent/JPH06500546A/ja active Pending
- 1991-08-23 DE DE69111815T patent/DE69111815T2/de not_active Expired - Fee Related
-
1993
- 1993-02-23 NO NO93930631A patent/NO930631L/no unknown
- 1993-02-23 FI FI930799A patent/FI930799A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IE912983A1 (en) | 1992-02-26 |
IL99211A0 (en) | 1992-07-15 |
NO930631L (no) | 1993-04-23 |
CA2089768A1 (fr) | 1992-02-25 |
DK203990D0 (da) | 1990-08-24 |
DK0544765T3 (da) | 1995-12-27 |
DE69111815D1 (de) | 1995-09-07 |
WO1992003426A1 (fr) | 1992-03-05 |
PT98768A (pt) | 1992-07-31 |
JPH06500546A (ja) | 1994-01-20 |
US5246935A (en) | 1993-09-21 |
ZA916652B (en) | 1992-05-27 |
PT98768B (pt) | 1999-01-29 |
FI930799A0 (fi) | 1993-02-23 |
AU8441391A (en) | 1992-03-17 |
EP0544765A1 (fr) | 1993-06-09 |
FI930799A (fi) | 1993-02-23 |
DE69111815T2 (de) | 1996-04-18 |
EP0544765B1 (fr) | 1995-08-02 |
IE73475B1 (en) | 1997-06-04 |
AU653956B2 (en) | 1994-10-20 |
NO930631D0 (no) | 1993-02-23 |
NZ239502A (en) | 1994-07-26 |
ATE125802T1 (de) | 1995-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |