DE69111815D1 - Piperazinylderivate mit Affinität zu 5-HT Rezeptoren. - Google Patents
Piperazinylderivate mit Affinität zu 5-HT Rezeptoren.Info
- Publication number
- DE69111815D1 DE69111815D1 DE69111815T DE69111815T DE69111815D1 DE 69111815 D1 DE69111815 D1 DE 69111815D1 DE 69111815 T DE69111815 T DE 69111815T DE 69111815 T DE69111815 T DE 69111815T DE 69111815 D1 DE69111815 D1 DE 69111815D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor
- affinity
- receptors
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK203990A DK203990D0 (da) | 1990-08-24 | 1990-08-24 | Piperazinylderivater |
PCT/DK1991/000244 WO1992003426A1 (en) | 1990-08-24 | 1991-08-23 | Piperazinyl derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69111815D1 true DE69111815D1 (de) | 1995-09-07 |
DE69111815T2 DE69111815T2 (de) | 1996-04-18 |
Family
ID=8109641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69111815T Expired - Fee Related DE69111815T2 (de) | 1990-08-24 | 1991-08-23 | Piperazinylderivate mit Affinität zu 5-HT Rezeptoren. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5246935A (de) |
EP (1) | EP0544765B1 (de) |
JP (1) | JPH06500546A (de) |
AT (1) | ATE125802T1 (de) |
AU (1) | AU653956B2 (de) |
CA (1) | CA2089768A1 (de) |
DE (1) | DE69111815T2 (de) |
DK (2) | DK203990D0 (de) |
FI (1) | FI930799A0 (de) |
IE (1) | IE73475B1 (de) |
IL (1) | IL99211A (de) |
NO (1) | NO930631L (de) |
NZ (1) | NZ239502A (de) |
PT (1) | PT98768B (de) |
WO (1) | WO1992003426A1 (de) |
ZA (1) | ZA916652B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364849A (en) * | 1989-04-22 | 1994-11-15 | John Wyeth & Brother, Limited | 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives |
US5436246A (en) * | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
BR9708254A (pt) * | 1996-03-25 | 1999-08-03 | Lilly Co Eli | Método para o tratamento da dor |
AU721338B2 (en) * | 1996-03-25 | 2000-06-29 | Eli Lilly And Company | Method for treating pain |
AU2587297A (en) | 1996-03-25 | 1997-10-17 | Eli Lilly And Company | Method for treating pain |
FR2753968B1 (fr) * | 1996-09-27 | 1998-11-27 | Sod Conseils Rech Applic | Nouvelles heteroaryloxyethylamines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
US6344458B1 (en) | 1998-12-17 | 2002-02-05 | American Home Products Corporation | Piperazine ethylamide derivatives |
WO2001062711A2 (en) * | 2000-02-22 | 2001-08-30 | Cv Therapeutics, Inc. | Substituted alkylene diamine compounds |
JP2003532676A (ja) * | 2000-05-12 | 2003-11-05 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | CNS障害を治療するための組合せられたドーパミンD2、5−HT1Aおよびαアドレノレセプターアゴニスト作用、を有する化合物の使用 |
FR2821356A1 (fr) * | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
SE0103648D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinolone compounds |
SE0103649D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinoline compounds |
US6750367B2 (en) * | 2002-05-09 | 2004-06-15 | Bayer Polymers Llc | Tetralin isocyanates |
CN1688527A (zh) | 2002-08-12 | 2005-10-26 | 武田药品工业株式会社 | 稠合的苯衍生物以及用途 |
MX2008010671A (es) * | 2006-02-21 | 2008-10-01 | Amgen Inc | Derivados de cinolina como inhibidores de fosfodiesterasa 10. |
KR101705727B1 (ko) | 2009-02-26 | 2017-02-10 | 레비바 파마슈티칼스, 아이엔씨. | 아릴피페라진 유도체의 조성물, 합성, 및 사용 방법 |
AU2013370966A1 (en) | 2012-12-24 | 2015-06-18 | Neurogastrx, Inc. | Methods for treating GI tract disorders |
WO2015200369A1 (en) | 2014-06-24 | 2015-12-30 | Neurogastrx, Inc. | Prodrugs of metopimazine |
MA41168A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
WO2018153297A1 (zh) * | 2017-02-24 | 2018-08-30 | 深圳市灵兰生物医药科技有限公司 | 新型多巴胺d3受体选择性配体及其制备方法和医药应用 |
US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3138597A (en) * | 1964-06-23 | Phenylpiperazinylalkyl carbamates | ||
US2836595A (en) * | 1958-05-27 | Piperazine derivatives and process for | ||
CA683208A (en) * | 1964-03-31 | Hayao Shin | Phenylpiperazinylalkyl esters and amides | |
GB952142A (en) * | 1961-05-26 | 1964-03-11 | Miles Lab | Phenylpiperazinylalkyl carbamates |
US4202898A (en) * | 1978-06-05 | 1980-05-13 | Synthelabo | Method of treating anxiety and depression |
AU532411B2 (en) * | 1979-03-01 | 1983-09-29 | Duphar International Research B.V. | Phenyl piperazine derivatives |
GB8303946D0 (en) * | 1983-02-12 | 1983-03-16 | Recordati Chem Pharm | Antihypertensive n-piperazinylalkanoylanilides |
US4882432A (en) * | 1989-01-09 | 1989-11-21 | American Home Products Corporation | Polycyclic-carbamic acid piperazinoalkyl esters and amides |
ES2076253T3 (es) * | 1989-05-19 | 1995-11-01 | Hoechst Roussel Pharma | N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos. |
FR2655988B1 (fr) * | 1989-12-20 | 1994-05-20 | Adir Cie | Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1990
- 1990-08-24 DK DK203990A patent/DK203990D0/da not_active Application Discontinuation
-
1991
- 1991-08-13 US US07/744,556 patent/US5246935A/en not_active Expired - Fee Related
- 1991-08-16 IL IL9921191A patent/IL99211A/en active IP Right Grant
- 1991-08-22 ZA ZA916652A patent/ZA916652B/xx unknown
- 1991-08-22 NZ NZ23950291A patent/NZ239502A/en unknown
- 1991-08-23 EP EP91915381A patent/EP0544765B1/de not_active Expired - Lifetime
- 1991-08-23 JP JP3514325A patent/JPH06500546A/ja active Pending
- 1991-08-23 DK DK91915381.7T patent/DK0544765T3/da active
- 1991-08-23 AU AU84413/91A patent/AU653956B2/en not_active Ceased
- 1991-08-23 IE IE298391A patent/IE73475B1/en not_active IP Right Cessation
- 1991-08-23 PT PT98768A patent/PT98768B/pt not_active IP Right Cessation
- 1991-08-23 WO PCT/DK1991/000244 patent/WO1992003426A1/en active IP Right Grant
- 1991-08-23 AT AT91915381T patent/ATE125802T1/de not_active IP Right Cessation
- 1991-08-23 DE DE69111815T patent/DE69111815T2/de not_active Expired - Fee Related
- 1991-08-23 CA CA002089768A patent/CA2089768A1/en not_active Abandoned
-
1993
- 1993-02-23 FI FI930799A patent/FI930799A0/fi not_active Application Discontinuation
- 1993-02-23 NO NO93930631A patent/NO930631L/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI930799A (fi) | 1993-02-23 |
CA2089768A1 (en) | 1992-02-25 |
NO930631L (no) | 1993-04-23 |
US5246935A (en) | 1993-09-21 |
FI930799A0 (fi) | 1993-02-23 |
DK0544765T3 (da) | 1995-12-27 |
IE73475B1 (en) | 1997-06-04 |
ZA916652B (en) | 1992-05-27 |
DK203990D0 (da) | 1990-08-24 |
AU653956B2 (en) | 1994-10-20 |
NO930631D0 (no) | 1993-02-23 |
IE912983A1 (en) | 1992-02-26 |
EP0544765A1 (de) | 1993-06-09 |
ATE125802T1 (de) | 1995-08-15 |
IL99211A (en) | 1996-01-31 |
EP0544765B1 (de) | 1995-08-02 |
IL99211A0 (en) | 1992-07-15 |
PT98768B (pt) | 1999-01-29 |
PT98768A (pt) | 1992-07-31 |
JPH06500546A (ja) | 1994-01-20 |
NZ239502A (en) | 1994-07-26 |
DE69111815T2 (de) | 1996-04-18 |
WO1992003426A1 (en) | 1992-03-05 |
AU8441391A (en) | 1992-03-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |