IL98638A - אנלוגים של גורם המשחרר הורמון הגדילה של בני אדם, הכנתם ותכשירי רוקחות המכילים אותם - Google Patents
אנלוגים של גורם המשחרר הורמון הגדילה של בני אדם, הכנתם ותכשירי רוקחות המכילים אותםInfo
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- IL98638A IL98638A IL9863891A IL9863891A IL98638A IL 98638 A IL98638 A IL 98638A IL 9863891 A IL9863891 A IL 9863891A IL 9863891 A IL9863891 A IL 9863891A IL 98638 A IL98638 A IL 98638A
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- 238000004809 thin layer chromatography Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54626890A | 1990-06-29 | 1990-06-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL98638A0 IL98638A0 (en) | 1992-07-15 |
| IL98638A true IL98638A (he) | 1995-07-31 |
Family
ID=24179626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9863891A IL98638A (he) | 1990-06-29 | 1991-06-27 | אנלוגים של גורם המשחרר הורמון הגדילה של בני אדם, הכנתם ותכשירי רוקחות המכילים אותם |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5696089A (he) |
| EP (1) | EP0544706A4 (he) |
| JP (1) | JPH06500311A (he) |
| AU (1) | AU656144B2 (he) |
| CA (1) | CA2085362A1 (he) |
| IE (1) | IE912282A1 (he) |
| IL (1) | IL98638A (he) |
| NZ (1) | NZ238748A (he) |
| WO (1) | WO1992000095A1 (he) |
| ZA (1) | ZA914983B (he) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
| US5612470A (en) * | 1992-06-23 | 1997-03-18 | American Cyanamid Company | Nucleic acid encoding the growth hormone releasing hormone receptor |
| US5973114A (en) * | 1992-06-23 | 1999-10-26 | The University Of Virginia Patent Foundation | Isolation and characterization of the growth hormone releasing hormone receptor |
| US5583010A (en) * | 1992-06-23 | 1996-12-10 | American Cyanamid Company | Nucleic acid molecule encoding the porcine growth hormone receptor |
| US5591641A (en) * | 1992-06-23 | 1997-01-07 | American Cyanamid Company | Nucleic acid encoding the growth hormone releasing hormone receptor |
| IL106860A (he) * | 1992-09-15 | 1999-08-17 | Thorner Michael O | בידור, איפיון ורצף חלבוני של רספטור הורמוני המשחרר את הורמון הגדילה ושכפול הגן המקודד עבור רספטור הורמוני המשחרר את הורמון הגדילה |
| US6150330A (en) | 1996-01-11 | 2000-11-21 | Pharmacia & Upjohn Company | Aqueous prolonged release formulation |
| EP0922446A1 (en) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Solution-phase site-specific preparation of GRF-PEG conjugates |
| US6696063B1 (en) | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
| DE60023906T2 (de) | 1999-07-26 | 2006-07-20 | Baylor College Of Medicine, Houston | Superaktive, wachstumshormone freisetzende hormonanaloge vom schwein |
| US20040192593A1 (en) * | 1999-07-26 | 2004-09-30 | Baylor College Of Medicine | Protease resistant ti-growth hormone releasing hormone |
| AR035671A1 (es) * | 2000-12-12 | 2004-06-23 | Advisys Inc | Administracion de secuencia de acido nucleico a un animal hembra, para aumentar el crecimiento de la descendencia |
| BR0213965A (pt) * | 2001-10-26 | 2005-03-15 | Baylor College Medicine | Composição e método para alterar as propriedades de massa corporal magra e ósseas em um indivìduo |
| WO2003049700A2 (en) | 2001-12-11 | 2003-06-19 | Advisys, Inc. | Growth hormone releasing hormone suplementation for treating chronically ill subjects |
| EP1499731B1 (en) * | 2002-02-07 | 2011-05-25 | Baylor College Of Medicine | Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy |
| CA2513743C (en) * | 2003-01-28 | 2013-06-25 | Advisys, Inc. | Reducing culling in herd animals growth hormone releasing hormone (ghrh) |
| TW200424214A (en) * | 2003-04-21 | 2004-11-16 | Advisys Inc | Plasmid mediated GHRH supplementation for renal failures |
| EP1660530A2 (en) * | 2003-08-04 | 2006-05-31 | Advisys, Inc. | Canine specific growth hormone releasing hormone |
| ATE467417T1 (de) | 2003-12-31 | 2010-05-15 | VGX Pharmaceuticals LLC | Reduzierung von arthritis und lahmheit bei personen unter supllement von wachstumshormon freisetzendem hormon (ghrh) |
| US7517863B2 (en) * | 2004-01-20 | 2009-04-14 | Vgx Pharmaceuticals, Inc. | Enhanced secretion/retention of growth hormone releasing hormone (GHRH) from muscle cells by species-specific signal peptide |
| US20060025368A1 (en) * | 2004-07-23 | 2006-02-02 | Advisys, Inc. | Growth hormone releasing hormone enhances vaccination response |
| WO2008006019A2 (en) * | 2006-07-06 | 2008-01-10 | Advisys Inc. | Growth hormone releasing hormone treatment to decrease cholesterol levels |
| GB0906143D0 (en) * | 2009-04-09 | 2009-05-20 | Nuvia Ltd | Radioactive waste storage |
| WO2010121352A1 (en) * | 2009-04-20 | 2010-10-28 | Theratechnologies Inc. | Use of (hexenoyl trans-3)hgrf(l-44)nh2 and simvastatin in combination therapy |
| US20100267635A1 (en) * | 2009-04-20 | 2010-10-21 | Theratechonolgies Inc. | Use of protease inhibitors and grf molecules in combination therapy |
| WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
| CN109153712B (zh) | 2016-04-19 | 2022-09-16 | 格里芬制药国际公司 | Peg化生物活性肽及其用途 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025499A (en) * | 1975-11-03 | 1977-05-24 | Abbott Laboratories | Preparation of histidine-containing peptides |
| US4618598A (en) * | 1982-04-12 | 1986-10-21 | Duke University | Method of regulating hormone function or release |
| US4517181A (en) * | 1982-09-15 | 1985-05-14 | The Salk Institute For Biological Studies | Mammalian PGRF |
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4595676A (en) * | 1983-04-26 | 1986-06-17 | The Salk Institute For Biological Studies | Rat hypothalamic GRF |
| US4703035A (en) * | 1982-10-04 | 1987-10-27 | The Salk Institute For Biological Studies | Human pancreatic GRF amidated fragments |
| US4529595A (en) * | 1983-01-13 | 1985-07-16 | The Salk Institute For Biological Studies | GRF Analogs |
| US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| DK162130C (da) * | 1983-03-07 | 1992-03-02 | Hoffmann La Roche | Grf-analoge peptider, fremgangsmaade til fremstilling deraf, grf-analoge peptider som terapeutiske midler, anvendelse af grf-analoge peptider, fremgangsmaade til fremstilling af farmaceutiske praeparater indeholdende grf-analoge peptider samt parenterale farmaceutiske praeparater indeholdende grf-analoge peptider |
| US4732972A (en) * | 1983-03-07 | 1988-03-22 | Hoffmann-La Roche Inc. | Polypeptides having growth hormone releasing activity |
| US4628043A (en) * | 1983-04-26 | 1986-12-09 | The Salk Institute For Biological Studies | Hypothalamic GRF agonists |
| US4605643A (en) * | 1984-03-02 | 1986-08-12 | The Salk Institute For Biological Studies | Ovine GRF |
| US4610976A (en) * | 1983-08-29 | 1986-09-09 | The Salk Institute For Biological Studies | Porcine GRF |
| US4585756A (en) * | 1983-10-12 | 1986-04-29 | The Salk Institute For Biological Studies | Bovine GRF |
| US4626523A (en) * | 1983-09-13 | 1986-12-02 | The Salk Institute For Biological Studies | GRF analogs II |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| US4562175A (en) * | 1984-02-03 | 1985-12-31 | Ding Chang | Synthetic peptides |
| US4649039A (en) * | 1984-07-03 | 1987-03-10 | E. I. Du Pont De Nemours And Company | Radiolabeling of methionine-containing proteins and peptides |
| US4622312A (en) * | 1984-09-24 | 1986-11-11 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4662312A (en) * | 1984-12-28 | 1987-05-05 | Nissin Electric Co., Ltd. | Apparatus for ion and vapor deposition |
| CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US4783524A (en) * | 1985-09-17 | 1988-11-08 | Monsanto Company | Growth factors |
| US4784987A (en) * | 1987-01-13 | 1988-11-15 | The Salk Institute For Biological Studies | GRF analogs VI |
| US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
| US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
| NZ227770A (en) * | 1988-01-29 | 1991-08-27 | Upjohn Co | Growth hormone releasing factor (grf) peptide containing a cysteic acid residue in position 3 or 25 |
| CA2026776A1 (en) * | 1989-01-27 | 1990-07-28 | Alan R. Friedman | Stabilized, potent grf analogs |
| WO1990015821A1 (en) * | 1989-06-16 | 1990-12-27 | The Upjohn Company | Stabilized, potent grf analogs |
-
1991
- 1991-06-27 CA CA002085362A patent/CA2085362A1/en not_active Abandoned
- 1991-06-27 NZ NZ238748A patent/NZ238748A/xx unknown
- 1991-06-27 ZA ZA914983A patent/ZA914983B/xx unknown
- 1991-06-27 IL IL9863891A patent/IL98638A/he not_active IP Right Cessation
- 1991-06-27 AU AU83109/91A patent/AU656144B2/en not_active Ceased
- 1991-06-27 EP EP19910914164 patent/EP0544706A4/en not_active Withdrawn
- 1991-06-27 JP JP3513314A patent/JPH06500311A/ja active Pending
- 1991-06-27 WO PCT/US1991/004606 patent/WO1992000095A1/en not_active Application Discontinuation
- 1991-06-28 IE IE228291A patent/IE912282A1/en unknown
-
1995
- 1995-06-05 US US08/461,218 patent/US5696089A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA914983B (en) | 1992-03-25 |
| IE912282A1 (en) | 1992-01-01 |
| US5696089A (en) | 1997-12-09 |
| WO1992000095A1 (en) | 1992-01-09 |
| IL98638A0 (en) | 1992-07-15 |
| EP0544706A4 (en) | 1993-10-13 |
| CA2085362A1 (en) | 1991-12-30 |
| AU8310991A (en) | 1992-01-23 |
| EP0544706A1 (en) | 1993-06-09 |
| JPH06500311A (ja) | 1994-01-13 |
| AU656144B2 (en) | 1995-01-27 |
| NZ238748A (en) | 1993-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |